Strain Name:
C57BL/6J-MtgxR6022Btlr/Mmmh
Stock Number:
043256-MU
Citation ID:
RRID:MMRRC_043256-MU
Other Names:
R6022 (G1), C57BL/6J-MtgxR6022Btlr
Major Collection:

Strain Information

Lrrn3
Name: leucine rich repeat protein 3, neuronal
Synonyms: NLRR-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16981
VEGA: 12
Homologene: 36315
Uri1
Name: URI1, prefoldin-like chaperone
Synonyms: NNX3, Rmp, C80913
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19777
Homologene: 2813
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Brix1
Name: BRX1, biogenesis of ribosomes
Synonyms: 1110064N10Rik, Bxdc2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67832
Homologene: 10133
Kif1b
Name: kinesin family member 1B
Synonyms: N-3 kinesin, KIF1Bp130, KIF1Bp204, A530096N05Rik, Kif1b beta, Kif1b alpha, D4Mil1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Atxn2l
Name: ataxin 2-like
Synonyms: A2D, A2lp, A2RP, A2LG
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233871
Homologene: 16513
Dock4
Name: dedicator of cytokinesis 4
Synonyms: 6330411N01Rik, EST N28122
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, tbl, 2810449H11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Ttk
Name: Ttk protein kinase
Synonyms: Mps1, Esk1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22137
Homologene: 2489
Ptprj
Name: protein tyrosine phosphatase receptor type J
Synonyms: Scc-1, Byp, CD148, DEP-1, Scc1, RPTPJ
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Gcat
Name: glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)
Synonyms: aminoacetone synthase, Kbl
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26912
VEGA: 15
HGNC: HGNC:4188
Homologene: 8475
Fcrl5
Name: Fc receptor-like 5
Synonyms: BXMAS1-like protein 2, mBXMH2, Fcrh3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329693
Homologene: 137404
Mme
Name: membrane metallo endopeptidase
Synonyms: CD10, neprilysin, 6030454K05Rik, neutral endopeptidase, NEP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
AW209491
Name: expressed sequence AW209491
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105351
VEGA: 13
Homologene: 11439
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Marco
Name: macrophage receptor with collagenous structure
Synonyms: Scara2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17167
HGNC: HGNC:6895
Homologene: 4928
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Dpysl4
Name: dihydropyrimidinase-like 4
Synonyms: Drp-4, Crmp3, Ulip4, unc-33-like phosphoprotein 4, DPY4, CRMP-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26757
HGNC: HGNC:3016
Homologene: 4691
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Xpc
Name: xeroderma pigmentosum, complementation group C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22591
Homologene: 3401
Trmt11
Name: tRNA methyltransferase 11
Synonyms: 3110045I18Rik, 2410075D05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73681
VEGA: 10
Homologene: 6876
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, Gm1557, 4930503E15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Tram2
Name: translocating chain-associating membrane protein 2
Synonyms: C330003D03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170829
Homologene: 8183
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230806
Homologene: 19232
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70381
Homologene: 9120
Adam9
Name: ADAM metallopeptidase domain 9
Synonyms: Mltng, MDC9, Mltng, MDC9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11502
HGNC: HGNC:216
Homologene: 20824
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
Arhgef26
Name: Rho guanine nucleotide exchange factor 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 622434
Homologene: 9204
Vmn1r173
Name: vomeronasal 1 receptor 173
Synonyms: Gm5892
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545934
Homologene: 79577
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Jmy
Name: junction-mediating and regulatory protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 57748
VEGA: 13
Homologene: 10955
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: 1600029O10Rik, CoaSt6, collaborator of Stat6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 547253
Homologene: 19697
Zfp438
Name: zinc finger protein 438
Synonyms: B830013J05Rik, 9430091M14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240186
VEGA: 18
Homologene: 18695
Ces1g
Name: carboxylesterase 1G
Synonyms: Ses-1, Ces1, Ces-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12623
HGNC: HGNC:1863
Homologene: 137354
Dok5
Name: docking protein 5
Synonyms: 2700055C10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76829
Homologene: 10195
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Rnf150
Name: ring finger protein 150
Synonyms: A630007N06Rik, C030044C12Rik, Greul5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330812
Homologene: 33783
Prx
Name: periaxin
Synonyms: L-Periaxin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19153
Homologene: 76542
Speer4a2
Name: spermatogenesis associated glutamate (E)-rich protein 4A2
Synonyms: Gm10471
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100039045
Homologene: 69402
Phc3
Name: polyhomeotic 3
Synonyms: HPH3, E030046K01Rik, EDR3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241915
Homologene: 69390
Endog
Name: endonuclease G
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13804
HGNC: HGNC:3346
Homologene: 55823
Trbv26
Name: T cell receptor beta, variable 26
Synonyms: Gm16909, Tcrb-V3.1, Tcrb-V3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110315
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 21,079,137 bp
  • G to A, chromosome 1 at 120,488,565 bp
  • A to T, chromosome 1 at 160,110,358 bp
  • A to G, chromosome 2 at 30,172,909 bp
  • A to T, chromosome 2 at 90,471,323 bp
  • A to G, chromosome 2 at 170,879,222 bp
  • A to G, chromosome 3 at 30,930,025 bp
  • C to T, chromosome 3 at 62,428,939 bp
  • T to A, chromosome 3 at 63,364,797 bp
  • A to G, chromosome 3 at 87,455,763 bp
  • T to A, chromosome 3 at 103,886,105 bp
  • A to T, chromosome 4 at 134,074,273 bp
  • T to C, chromosome 4 at 149,198,532 bp
  • T to G, chromosome 5 at 26,084,679 bp
  • A to T, chromosome 5 at 144,199,191 bp
  • T to A, chromosome 6 at 41,227,575 bp
  • A to G, chromosome 6 at 91,499,636 bp
  • A to G, chromosome 7 at 23,702,835 bp
  • A to G, chromosome 7 at 27,517,573 bp
  • A to T, chromosome 7 at 37,961,477 bp
  • A to G, chromosome 7 at 126,496,435 bp
  • A to T, chromosome 7 at 139,086,084 bp
  • T to C, chromosome 8 at 25,003,305 bp
  • T to C, chromosome 8 at 83,042,729 bp
  • T to A, chromosome 8 at 93,328,457 bp
  • A to G, chromosome 9 at 66,483,685 bp
  • T to C, chromosome 9 at 83,839,322 bp
  • A to G, chromosome 10 at 30,587,501 bp
  • G to T, chromosome 10 at 103,215,534 bp
  • T to G, chromosome 11 at 9,290,759 bp
  • A to G, chromosome 11 at 119,486,010 bp
  • A to G, chromosome 12 at 11,458,522 bp
  • T to C, chromosome 12 at 40,748,110 bp
  • T to C, chromosome 12 at 41,453,430 bp
  • C to T, chromosome 13 at 14,637,780 bp
  • G to T, chromosome 13 at 93,453,578 bp
  • C to T, chromosome 15 at 10,476,589 bp
  • T to C, chromosome 15 at 79,042,278 bp
  • G to A, chromosome 16 at 35,841,457 bp
  • A to G, chromosome 17 at 17,377,773 bp
  • T to A, chromosome 17 at 24,496,735 bp
  • T to A, chromosome 18 at 5,213,419 bp
  • A to C, chromosome 18 at 19,966,338 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6022 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043256-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.