Strain Name:
C57BL/6J-MtgxR6039Btlr/Mmmh
Stock Number:
043259-MU
Citation ID:
RRID:MMRRC_043259-MU
Other Names:
R6039 (G1), C57BL/6J-MtgxR6039Btlr
Major Collection:

Strain Information

Chat
Name: choline acetyltransferase
Synonyms: B230380D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12647
VEGA: 14
HGNC: HGNC:1912
Homologene: 40693
Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: F4/80, DD7A5-7, TM7LN3, EGF-TM7, Ly71, Emr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Dnmt1
Name: DNA methyltransferase (cytosine-5) 1
Synonyms: MTase, Dnmt1o, Cxxc9, MommeD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: Hbp, 1200004O12Rik, 5730456G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56324
Homologene: 68490
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Sf3a2
Name: splicing factor 3a, subunit 2
Synonyms: SFA66, PRP11, Sap62, 66kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20222
Homologene: 133823
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Sgo2a
Name: shugoshin 2A
Synonyms: 5730576N04Rik, Tripin, 1110007N04Rik, D1Ertd8e, Sgol2, Sgol2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68549
Homologene: 51867
Rax
Name: retina and anterior neural fold homeobox
Synonyms: Rx, ey1, E130303K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 19434
VEGA: 18
Homologene: 8383
Dlst
Name: dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Synonyms: 4930529O08Rik, 1600017E01Rik, 4632413C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 78920
VEGA: 12
HGNC: HGNC:2911
Homologene: 1456
Il20
Name: interleukin 20
Synonyms: Zcyto10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 58181
HGNC: HGNC:6002
Homologene: 10286
Tln1
Name: talin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21894
Homologene: 21267
Zfp644
Name: zinc finger protein 644
Synonyms: 1110068L01Rik, BM-005, Zep-2, D5Ertd689e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52397
Homologene: 12971
Slc38a9
Name: solute carrier family 38, member 9
Synonyms: 9430067K09Rik, 6720411P22Rik, 9130023D20Rik, 4833412L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 268706
VEGA: 13
Homologene: 18139
Wdr6
Name: WD repeat domain 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83669
Homologene: 117682
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: 4930556H18Rik, 1700048H13Rik, 2310009M18Rik, D630041K24Rik, STAMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320244
Homologene: 9013
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: dunce, Dpde3, 9630011N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Slc5a8
Name: solute carrier family 5 (iodide transporter), member 8
Synonyms: SMCT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216225
VEGA: 10
Homologene: 64832
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Nlrp12
Name: NLR family, pyrin domain containing 12
Synonyms: Nalp12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 378425
Homologene: 16972
Cdkn3
Name: cyclin-dependent kinase inhibitor 3
Synonyms: 2410006H10Rik, KAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72391
VEGA: 14
HGNC: HGNC:1791
Homologene: 3805
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 52864
Homologene: 23770
Hspb7
Name: heat shock protein family, member 7 (cardiovascular)
Synonyms: cvHsp, Hsp25-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29818
HGNC: HGNC:5249
Homologene: 8480
C8a
Name: complement component 8, alpha polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230558
HGNC: HGNC:1352
Homologene: 472
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Adamts9
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9
Synonyms: 1810011L16Rik, E030027K14Rik, 8430403M15Rik, Mhdaund4, Gsfund3, UND3, Mhdaund3, UND4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101401
Homologene: 18821
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217718
Homologene: 13222
Fetub
Name: fetuin beta
Synonyms: 2310011O17Rik, D17980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 59083
VEGA: 16
HGNC: HGNC:3658
Homologene: 8660
Klhl32
Name: kelch-like 32
Synonyms: LOC384000, D4Ertd389e, 6430524H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 212390
Homologene: 14173
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: Slo, mSlo1, Slo1, MaxiK, BK channel alpha subunit, 5730414M22Rik, BKCa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269610
Homologene: 56712
Pigs
Name: phosphatidylinositol glycan anchor biosynthesis, class S
Synonyms: LOC276846, LOC245087
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276846
Homologene: 41963
Cyp4a12a
Name: cytochrome P450, family 4, subfamily a, polypeptide 12a
Synonyms: Cyp4a12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277753
Homologene: 134044
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546980
Homologene: 115466
Bmp3
Name: bone morphogenetic protein 3
Synonyms: 9530029I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 110075
HGNC: HGNC:1070
Homologene: 927
Paqr4
Name: progestin and adipoQ receptor family member IV
Synonyms: 1500004C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76498
VEGA: 17
Homologene: 22278
Krt77
Name: keratin 77
Synonyms: 4732484G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 406220
Homologene: 45490
Ptprr
Name: protein tyrosine phosphatase, receptor type, R
Synonyms: PTPBR7, PTP-SL, RPTPRR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Psg28
Name: pregnancy-specific beta-1-glycoprotein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114871
Homologene: 110989
Pcgf5
Name: polycomb group ring finger 5
Synonyms: 5830443C21Rik, 9530023M17Rik, 1110054A01Rik, 0610009F02Rik, 5830406C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76073
VEGA: 19
Homologene: 12632
Parp8
Name: poly (ADP-ribose) polymerase family, member 8
Synonyms: 2810430O08Rik, D13Ertd275e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 52552
VEGA: 13
Homologene: 11621
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244199
Homologene: 18255
Fstl1
Name: follistatin-like 1
Synonyms: TSC-36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14314
HGNC: HGNC:3972
Homologene: 5144
Arhgap24
Name: Rho GTPase activating protein 24
Synonyms: 0610025G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231532
Homologene: 32754
Muc1
Name: mucin 1, transmembrane
Synonyms: EMA, CD227, Muc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Ptgir
Name: prostaglandin I receptor (IP)
Synonyms: prostacyclin receptor, IP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19222
HGNC: HGNC:9602
Homologene: 7496
Polh
Name: polymerase (DNA directed), eta (RAD 30 related)
Synonyms: RAD30A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 80905
VEGA: 17
HGNC: HGNC:9181
Homologene: 38189
Asb1
Name: ankyrin repeat and SOCS box-containing 1
Synonyms: 1700029O08Rik, 1700054C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 65247
Homologene: 9390
Zfp853
Name: zinc finger protein 853
Synonyms: LOC330230
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330230
Trav4-2
Name: T cell receptor alpha variable 4-2
Synonyms: Gm13953
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100126462
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 58,016,616 bp
  • T to C, chromosome 1 at 91,547,026 bp
  • T to A, chromosome 1 at 130,910,741 bp
  • T to A, chromosome 1 at 188,319,020 bp
  • T to C, chromosome 2 at 52,709,599 bp
  • C to T, chromosome 2 at 76,884,418 bp
  • C to T, chromosome 2 at 125,363,880 bp
  • T to A, chromosome 2 at 125,773,216 bp
  • T to C, chromosome 3 at 56,005,117 bp
  • T to C, chromosome 3 at 87,809,301 bp
  • T to C, chromosome 3 at 89,232,029 bp
  • A to G, chromosome 4 at 24,792,615 bp
  • G to C, chromosome 4 at 43,555,052 bp
  • A to G, chromosome 4 at 104,845,942 bp
  • T to C, chromosome 4 at 115,327,223 bp
  • A to G, chromosome 4 at 141,423,904 bp
  • CAAGAAGAAGAAGAAGAA to CAAGAAGAAGAAGAA, chromosome 4 at 152,353,621 bp
  • T to C, chromosome 5 at 98,872,350 bp
  • T to C, chromosome 5 at 102,880,786 bp
  • A to G, chromosome 5 at 106,635,425 bp
  • G to A, chromosome 5 at 143,288,774 bp
  • C to T, chromosome 6 at 92,908,546 bp
  • A to T, chromosome 7 at 3,241,372 bp
  • A to T, chromosome 7 at 16,906,890 bp
  • T to C, chromosome 7 at 18,426,182 bp
  • T to A, chromosome 7 at 85,958,318 bp
  • A to G, chromosome 7 at 102,134,795 bp
  • G to A, chromosome 7 at 107,789,111 bp
  • C to G, chromosome 8 at 35,809,364 bp
  • A to T, chromosome 9 at 20,926,420 bp
  • CTG to C, chromosome 9 at 108,573,795 bp
  • A to G, chromosome 10 at 80,801,463 bp
  • A to G, chromosome 10 at 88,886,574 bp
  • G to A, chromosome 10 at 116,236,763 bp
  • T to A, chromosome 11 at 78,341,825 bp
  • T to A, chromosome 12 at 85,118,890 bp
  • G to A, chromosome 12 at 85,313,085 bp
  • T to A, chromosome 12 at 85,831,955 bp
  • A to T, chromosome 13 at 109,948,342 bp
  • A to T, chromosome 13 at 112,669,697 bp
  • A to G, chromosome 13 at 116,877,598 bp
  • T to C, chromosome 14 at 23,309,037 bp
  • A to G, chromosome 14 at 32,449,027 bp
  • G to A, chromosome 14 at 46,769,916 bp
  • G to A, chromosome 14 at 53,418,409 bp
  • C to A, chromosome 15 at 101,860,916 bp
  • G to A, chromosome 16 at 3,986,047 bp
  • C to T, chromosome 16 at 22,932,331 bp
  • T to A, chromosome 16 at 37,821,176 bp
  • T to C, chromosome 17 at 23,739,994 bp
  • C to T, chromosome 17 at 46,188,033 bp
  • C to A, chromosome 17 at 57,406,859 bp
  • T to G, chromosome 17 at 71,110,751 bp
  • C to T, chromosome 18 at 65,935,347 bp
  • T to A, chromosome 19 at 36,442,906 bp
  • T to C, chromosome 19 at 37,977,684 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6039 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043259-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.