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Strain Name:
C57BL/6J-MtgxR4862Btlr/Mmmh
Stock Number:
043260-MU
Citation ID:
RRID:MMRRC_043260-MU
Other Names:
R4862 (G1)
Major Collection:

Strain Information

Hapln1
Name: hyaluronan and proteoglycan link protein 1
Synonyms: link protein, cartilage linking protein 1, Crtl1l, Crtl1, CLP, LP-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12950
VEGA: 13
HGNC: HGNC:2380
Homologene: 1420
Zfa-ps
Name: zinc finger protein, autosomal, pseudogene
Synonyms: Zfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22639
Tbce
Name: tubulin-specific chaperone E
Synonyms: 2610206D02Rik, C530005D02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70430
Homologene: 37744
Mapkap1
Name: mitogen-activated protein kinase associated protein 1
Synonyms: D230039K05Rik, Sin1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227743
Homologene: 11473
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: LOC380993, Zfp406, Zfat1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 1700066F09Rik, 2310028E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Arid4a
Name: AT-rich interaction domain 4A
Synonyms: A630067N03Rik, Rbbp1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238247
HGNC: HGNC:9885
Homologene: 11303
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 44,058,018 bp
  • T to G, chromosome 1 at 58,095,157 bp
  • A to G, chromosome 2 at 34,623,430 bp
  • G to T, chromosome 2 at 36,237,255 bp
  • T to A, chromosome 2 at 86,829,532 bp
  • A to T, chromosome 3 at 83,898,210 bp
  • A to G, chromosome 3 at 108,467,833 bp
  • T to C, chromosome 3 at 141,789,773 bp
  • A to C, chromosome 4 at 122,844,449 bp
  • A to G, chromosome 5 at 35,589,739 bp
  • T to A, chromosome 5 at 143,289,661 bp
  • T to G, chromosome 6 at 41,032,411 bp
  • T to C, chromosome 6 at 42,744,555 bp
  • C to A, chromosome 6 at 70,457,781 bp
  • C to T, chromosome 6 at 73,121,788 bp
  • A to T, chromosome 7 at 46,229,240 bp
  • A to G, chromosome 9 at 7,147,717 bp
  • G to T, chromosome 9 at 98,581,267 bp
  • G to T, chromosome 10 at 52,543,096 bp
  • A to T, chromosome 10 at 115,462,764 bp
  • A to G, chromosome 11 at 60,778,071 bp
  • A to G, chromosome 11 at 61,313,694 bp
  • A to T, chromosome 11 at 99,365,110 bp
  • A to T, chromosome 12 at 71,075,947 bp
  • A to G, chromosome 12 at 71,942,207 bp
  • A to G, chromosome 13 at 13,998,419 bp
  • A to G, chromosome 13 at 20,449,512 bp
  • G to A, chromosome 13 at 89,601,452 bp
  • G to A, chromosome 13 at 92,508,256 bp
  • A to G, chromosome 14 at 33,100,903 bp
  • C to A, chromosome 15 at 68,180,110 bp
  • T to A, chromosome 16 at 93,887,134 bp
  • A to T, chromosome 17 at 7,769,735 bp
  • A to G, chromosome 17 at 35,883,262 bp
  • C to T, chromosome X at 74,277,038 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4862 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@missouri.edu
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

When this strain becomes available, Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.