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Strain Name:
C57BL/6J-MtgxR5617Btlr
Stock Number:
043276-MU
Citation ID:
RRID:MMRRC_043276-MU
Other Names:
R5617 (G1)
Major Collection:

Strain Information

Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Plaat1
Name: phospholipase A and acyltransferase 1
Synonyms: A-C1, 2810012B06Rik, Hrasls
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27281
Homologene: 8452
Clcnka
Name: chloride channel, voltage-sensitive Ka
Synonyms: CLC-K1, Clcnk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12733
Homologene: 65
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: RAB5 effector protein, neurocrescin, rabaptin-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54189
Homologene: 3451
Fbxo38
Name: F-box protein 38
Synonyms: SP329, 6030410I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107035
VEGA: 18
Homologene: 34526
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
HGNC: HGNC:9848
Homologene: 87808
Slc25a17
Name: solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
Synonyms: PMP34, 34kDa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20524
VEGA: 15
Homologene: 4637
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 89,954,462 bp
  • T to C, chromosome 1 at 95,314,247 bp
  • A to G, chromosome 1 at 127,551,330 bp
  • G to A, chromosome 1 at 127,822,966 bp
  • A to T, chromosome 1 at 181,828,902 bp
  • T to C, chromosome 1 at 192,120,130 bp
  • T to A, chromosome 2 at 86,594,001 bp
  • G to A, chromosome 2 at 120,046,484 bp
  • T to C, chromosome 2 at 131,179,014 bp
  • T to C, chromosome 3 at 90,275,626 bp
  • A to T, chromosome 3 at 102,947,829 bp
  • C to A, chromosome 3 at 146,646,310 bp
  • T to C, chromosome 4 at 41,716,407 bp
  • G to A, chromosome 4 at 126,745,047 bp
  • C to T, chromosome 4 at 141,389,317 bp
  • T to A, chromosome 5 at 34,870,806 bp
  • G to A, chromosome 5 at 54,109,733 bp
  • A to C, chromosome 6 at 116,403,520 bp
  • T to A, chromosome 7 at 10,170,934 bp
  • G to T, chromosome 7 at 39,363,652 bp
  • A to G, chromosome 7 at 58,803,675 bp
  • A to T, chromosome 7 at 103,979,714 bp
  • A to G, chromosome 7 at 104,142,433 bp
  • T to C, chromosome 7 at 143,692,947 bp
  • T to A, chromosome 9 at 105,397,835 bp
  • C to T, chromosome 9 at 106,474,505 bp
  • T to C, chromosome 9 at 106,651,076 bp
  • A to G, chromosome 10 at 13,474,065 bp
  • T to G, chromosome 10 at 58,465,667 bp
  • A to G, chromosome 10 at 74,635,672 bp
  • T to C, chromosome 10 at 106,951,990 bp
  • C to T, chromosome 11 at 9,277,891 bp
  • C to T, chromosome 11 at 70,917,529 bp
  • G to T, chromosome 11 at 83,004,721 bp
  • A to T, chromosome 11 at 120,656,345 bp
  • C to A, chromosome 12 at 115,834,254 bp
  • T to A, chromosome 13 at 3,933,432 bp
  • A to G, chromosome 15 at 23,226,768 bp
  • A to G, chromosome 15 at 27,902,748 bp
  • T to C, chromosome 15 at 38,030,657 bp
  • A to T, chromosome 15 at 71,622,016 bp
  • A to G, chromosome 15 at 76,174,532 bp
  • G to T, chromosome 15 at 81,360,774 bp
  • A to G, chromosome 15 at 98,122,226 bp
  • G to A, chromosome 15 at 100,585,993 bp
  • G to A, chromosome 15 at 101,947,609 bp
  • A to T, chromosome 16 at 29,220,410 bp
  • T to C, chromosome 16 at 42,134,423 bp
  • A to T, chromosome 16 at 48,074,164 bp
  • T to A, chromosome 17 at 47,378,242 bp
  • T to C, chromosome 18 at 12,498,936 bp
  • T to G, chromosome 18 at 36,998,816 bp
  • A to G, chromosome 18 at 62,505,971 bp
  • G to A, chromosome 19 at 24,750,401 bp
  • A to G, chromosome 19 at 29,812,463 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5617 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043276-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.