Strain Name:
C57BL/6J-MtgxR5630Btlr
Stock Number:
043281-MU
Citation ID:
RRID:MMRRC_043281-MU
Other Names:
R5630 (G1)
Major Collection:

Strain Information

Zfp143
Name: zinc finger protein 143
Synonyms: D7Ertd805e, pHZ-1, KRAB14, Zfp79, Zfp80-rs1, Staf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20841
Homologene: 56444
Aven
Name: apoptosis, caspase activation inhibitor
Synonyms: 1700013A01Rik, mAven-S, mAven-L, 1700056A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74268
Homologene: 10683
Rptor
Name: regulatory associated protein of MTOR, complex 1
Synonyms: raptor, 4932417H02Rik, Rap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74370
Homologene: 80210
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22390
Homologene: 31152
Prdx1
Name: peroxiredoxin 1
Synonyms: OSF-3, MSP23, Tdpx2, macrophage 23kDa stress protein, macrophase stress protein 22kDa, osteoblast specific factor 3, Trx dependent peroxide reductase 2, thioredoxin dependent peroxide reductase 2, TDX2, Paga, PrxI, PAG, Prx I, prx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18477
HGNC: HGNC:9352
Homologene: 99789
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Cdkal1
Name: CDK5 regulatory subunit associated protein 1-like 1
Synonyms: 6620401C13Rik, 1190005B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68916
Homologene: 9830
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Ap3s2
Name: adaptor-related protein complex 3, sigma 2 subunit
Synonyms: sigma 3B, [s]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11778
HGNC: HGNC:571
Homologene: 100592
Tox
Name: thymocyte selection-associated high mobility group box
Synonyms: 1700007F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 252838
Homologene: 8822
Clock
Name: circadian locomotor output cycles kaput
Synonyms: 5330400M04Rik, KAT13D, bHLHe8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Flrt1
Name: fibronectin leucine rich transmembrane protein 1
Synonyms: D630040I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 396184
VEGA: 19
HGNC: HGNC:3760
Homologene: 40864
Upf2
Name: UPF2 regulator of nonsense transcripts homolog (yeast)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 326622
Homologene: 6101
Pcmt1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
Synonyms: protein carboxyl methyltransferase, PIMT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18537
HGNC: HGNC:8728
Homologene: 135759
Cnih4
Name: cornichon family AMPA receptor auxiliary protein 4
Synonyms: D530030D03Rik, E430023H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98417
Homologene: 5932
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: 4930429G18Rik, C030002J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 78787
Homologene: 90902
Lbr
Name: lamin B receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98386
HGNC: HGNC:6518
Homologene: 2455
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Smox
Name: spermine oxidase
Synonyms: B130066H01Rik, SMO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228608
Homologene: 69268
Cpne5
Name: copine V
Synonyms: A830083G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240058
HGNC: HGNC:2318
Homologene: 23266
Tns2
Name: tensin 2
Synonyms: nep, nph, Tenc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: LOC381538, Gm1027, Heatr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381538
Homologene: 19633
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC6, SPC6, PC5A, PC5/6A, b2b585Clo, b2b1549Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Pcdhb5
Name: protocadherin beta 5
Synonyms: Pcdhb4A, PcdhbE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93876
HGNC: HGNC:8689
Homologene: 75103
Stox2
Name: storkhead box 2
Synonyms: 4933409N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71069
Homologene: 18414
Vmn2r83
Name: vomeronasal 2, receptor 83
Synonyms: EG625029
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625029
Homologene: 83669
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241175
Homologene: 104295
Or8g20
Name: olfactory receptor family 8 subfamily G member 20
Synonyms: IB3, MOR171-5, GA_x6K02T2PVTD-33181773-33180838, Olfr44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18343
VEGA: 9
HGNC: HGNC:8484
Homologene: 133633
Or8c10
Name: olfactory receptor family 8 subfamily C member 10
Synonyms: GA_x6K02T2MYUG-19447-18473, MOR170-14, Olfr250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404312
VEGA: 9
Homologene: 74151
Kcnq3
Name: potassium voltage-gated channel, subfamily Q, member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110862
HGNC: HGNC:6297
Homologene: 20949
Klrb1a
Name: killer cell lectin-like receptor subfamily B member 1A
Synonyms: Nkrp1-a, Ly55a, NKR-P1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17057
HGNC: HGNC:6373
Homologene: 84369
Or5p4
Name: olfactory receptor family 5 subfamily P member 4
Synonyms: GA_x6K02T2PBJ9-10409785-10410723, MOR204-2, MOR204-39, Olfr481
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258927
Homologene: 105166
E330034G19Rik
Name: RIKEN cDNA E330034G19 gene
Synonyms: ZPAC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105418
Foxb1
Name: forkhead box B1
Synonyms: Hfh-e5.1, C43, TWH, Mf3, Fkh5, Foxb1b, Foxb1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64290
VEGA: 9
HGNC: HGNC:3799
Homologene: 8138
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Rrp8
Name: ribosomal RNA processing 8
Synonyms: 2900001K19Rik, 1500003O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101867
Homologene: 5621
Ccdc122
Name: coiled-coil domain containing 122
Synonyms: 4933415L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108811
Homologene: 51651
Cpa2
Name: carboxypeptidase A2, pancreatic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232680
HGNC: HGNC:2297
Homologene: 37541
Rcor2
Name: REST corepressor 2
Synonyms: 1A13, CoREST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104383
Homologene: 14280
Lsm8
Name: LSM8 homolog, U6 small nuclear RNA associated
Synonyms: 2010003I05Rik, Lsm8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76522
Homologene: 9419
Trgc2
Name: T cell receptor gamma, constant 2
Synonyms: Tcrg-C2, Trgc2, Gm16603
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107574
Scn2a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Sqrdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • GGAATCGTGCACTCGAA to GGAA, chromosome 1 at 34,188,785 bp
  • A to G, chromosome 1 at 100,072,069 bp
  • C to G, chromosome 1 at 181,162,183 bp
  • A to G, chromosome 1 at 181,816,964 bp
  • T to C, chromosome 2 at 6,027,301 bp
  • G to A, chromosome 2 at 25,408,945 bp
  • T to G, chromosome 2 at 65,726,365 bp
  • T to A, chromosome 2 at 112,514,545 bp
  • T to A, chromosome 2 at 122,809,357 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • C to T, chromosome 2 at 131,524,866 bp
  • C to CTGGAGT, chromosome 4 at 6,688,835 bp
  • T to C, chromosome 4 at 106,720,567 bp
  • T to A, chromosome 4 at 116,699,217 bp
  • T to C, chromosome 4 at 118,392,905 bp
  • T to C, chromosome 5 at 31,060,573 bp
  • G to A, chromosome 5 at 76,230,338 bp
  • T to A, chromosome 6 at 18,851,673 bp
  • T to A, chromosome 6 at 30,550,732 bp
  • A to T, chromosome 6 at 128,618,610 bp
  • A to T, chromosome 7 at 79,909,899 bp
  • C to A, chromosome 7 at 105,733,401 bp
  • T to A, chromosome 7 at 108,081,116 bp
  • C to T, chromosome 7 at 110,088,773 bp
  • TCCCC to TCCC, chromosome 7 at 110,124,569 bp
  • T to C, chromosome 8 at 47,191,890 bp
  • A to T, chromosome 8 at 125,860,958 bp
  • T to C, chromosome 9 at 38,368,106 bp
  • T to A, chromosome 9 at 39,484,951 bp
  • T to A, chromosome 9 at 69,760,120 bp
  • A to G, chromosome 10 at 7,649,093 bp
  • T to G, chromosome 10 at 58,479,076 bp
  • A to T, chromosome 10 at 79,491,951 bp
  • T to G, chromosome 11 at 119,756,249 bp
  • A to T, chromosome 13 at 11,601,805 bp
  • A to G, chromosome 13 at 19,305,109 bp
  • A to T, chromosome 13 at 29,777,215 bp
  • A to G, chromosome 14 at 20,565,057 bp
  • A to G, chromosome 14 at 24,308,268 bp
  • A to T, chromosome 14 at 77,092,776 bp
  • A to G, chromosome 15 at 66,025,122 bp
  • C to T, chromosome 15 at 102,108,934 bp
  • T to C, chromosome 17 at 29,226,216 bp
  • A to T, chromosome 18 at 37,321,155 bp
  • A to T, chromosome 19 at 7,096,465 bp
  • A to T, chromosome 19 at 7,271,051 bp
  • A to G, chromosome 19 at 17,575,831 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5630 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043281-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.