Strain Name:
C57BL/6J-MtgxR5633Btlr
Stock Number:
043284-MU
Citation ID:
RRID:MMRRC_043284-MU
Other Names:
R5633 (G1)
Major Collection:

Gene Information

Gnb5
Name: guanine nucleotide binding protein (G protein), beta 5
Synonyms: G beta 5, Gbeta5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 14697
VEGA: 9
HGNC: HGNC:4401
Homologene: 40714
Elp2
Name: elongator acetyltransferase complex subunit 2
Synonyms: StIP1, Statip1, Stat3-interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 58523
VEGA: 18
Homologene: 6019
Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: Acra-4, Acra4, a4 nicotinic receptor, alpha4 nAChR, alpha4-nAChR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74315
Homologene: 14427
P4htm
Name: prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms: P4h-tm, 4933406E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74443
Homologene: 41765
Dmtn
Name: dematin actin binding protein
Synonyms: Epb4.9, dematin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 13829
VEGA: 14
HGNC: HGNC:3382
Homologene: 1496
Lin9
Name: lin-9 homolog (C. elegans)
Synonyms: 2700022J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 72568
Homologene: 35252
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 208628
Homologene: 32227
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Smc4
Name: structural maintenance of chromosomes 4
Synonyms: 2500002A22Rik, Smc4l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70099
Homologene: 4015
Zfp407
Name: zinc finger protein 407
Synonyms: LOC240469, 6430585N13Rik, LOC381139
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240476
Homologene: 86402
Abcb8
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 8
Synonyms: 4833412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74610
HGNC: HGNC:49
Homologene: 5203
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105522
VEGA: 14
Homologene: 35374
Syt9
Name: synaptotagmin IX
Synonyms: Sytv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 60510
Homologene: 11062
Myo9a
Name: myosin IXa
Synonyms: C130068I12Rik, 4732465J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
B3galt5
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
Synonyms: 1190002B21Rik, b3Galt-V
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 93961
HGNC: HGNC:920
Homologene: 13230
Ckmt1
Name: creatine kinase, mitochondrial 1, ubiquitous
Synonyms: UbCKmit, mi-CK, Mt-CK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12716
Homologene: 69058
Med13
Name: mediator complex subunit 13
Synonyms: Trap240, 1110067M05Rik, Thrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 327987
Homologene: 21067
Rpn2
Name: ribophorin II
Synonyms: Rpn-2, 1300012C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20014
Homologene: 2214
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: polycystin-2, TRPP2, PC2, C030034P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Rpp30
Name: ribonuclease P/MRP 30 subunit
Synonyms: Rnasep2, TSG15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 54364
VEGA: 19
Homologene: 38180
Lmbrd1
Name: LMBR1 domain containing 1
Synonyms: 0910001K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68421
Homologene: 10156
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: 9830168K16Rik, Trrp7, TRPC7, LTRPC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 28240
Homologene: 20709
Itpkb
Name: inositol 1,4,5-trisphosphate 3-kinase B
Synonyms: 1110033J02Rik, E130307H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320404
HGNC: HGNC:6179
Homologene: 1672
Psmd5
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
Synonyms: 1500032A03Rik, S5b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66998
HGNC: HGNC:9563
Homologene: 37999
Aadacl4
Name: arylacetamide deacetylase like 4
Synonyms: Gm13177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 435815
Homologene: 82530
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Ica1
Name: islet cell autoantigen 1
Synonyms: ICA69, 69kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 15893
HGNC: HGNC:5343
Homologene: 7777
Fbxo43
Name: F-box protein 43
Synonyms: XErp1 homolog, 4930533G20Rik, early mitotic inhibitor 2, Emi2, endogenous meiotic inhibitor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 78803
VEGA: 15
Homologene: 66393
Slc41a1
Name: solute carrier family 41, member 1
Synonyms: B230315F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98396
Homologene: 14871
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms: IDPc, Idh-1, Id-1, E030024J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 15926
HGNC: HGNC:5382
Homologene: 21195
Dnajb13
Name: DnaJ heat shock protein family (Hsp40) member B13
Synonyms: 1700014P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69387
Homologene: 70141
Dhcr7
Name: 7-dehydrocholesterol reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13360
HGNC: HGNC:2860
Homologene: 1042
Parp8
Name: poly (ADP-ribose) polymerase family, member 8
Synonyms: D13Ertd275e, 2810430O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 52552
VEGA: 13
Homologene: 11621
Best1
Name: bestrophin 1
Synonyms: mBest1, best macular dystrophy, Vmd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 24115
Homologene: 37895
Slc47a1
Name: solute carrier family 47, member 1
Synonyms: MATE1, 1300013J15Rik, mMATE1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67473
Homologene: 34364
Chil6
Name: chitinase-like 6
Synonyms: BYm, BC051070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229688
Homologene: 77638
Eef2k
Name: eukaryotic elongation factor-2 kinase
Synonyms: eEF-2K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13631
Homologene: 7299
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: A330035H04Rik, Lacsl, Facl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216739
Homologene: 100939
Uap1l1
Name: UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
Synonyms: 5730445F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227620
Homologene: 71313
Acot3
Name: acyl-CoA thioesterase 3
Synonyms: PTE-Ia, Pte2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 171281
Homologene: 134585
Mn1
Name: meningioma 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 433938
HGNC: HGNC:7180
Homologene: 37620
Zpbp2
Name: zona pellucida binding protein 2
Synonyms: 1700017D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69376
Homologene: 18892
Stra6l
Name: STRA6-like
Synonyms: 1300002K09Rik, Rbpr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74152
Homologene: 81924
Ikzf2
Name: IKAROS family zinc finger 2
Synonyms: A730095J18Rik, Zfpn1a2, Helios
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22779
Homologene: 22659
Gnb2
Name: guanine nucleotide binding protein (G protein), beta 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14693
HGNC: HGNC:4398
Homologene: 68451
Gm11559
Name: predicted gene 11559
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 100415785
Homologene: 136354
Vmn1r91
Name: vomeronasal 1 receptor 91
Synonyms: Gm8442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 667067
Homologene: 104166
Bcas2
Name: breast carcinoma amplified sequence 2
Synonyms: C76366, 6430539P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 68183
HGNC: HGNC:975
Homologene: 4291
Olfr773
Name: olfactory receptor 773
Synonyms: Olfr773-ps1, MOR114-15, GA_x6K02T2PULF-10872859-10871923
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 257664
Homologene: 123776
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 73246
Homologene: 37125
BC053393
Name: cDNA sequence BC053393
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 407814
Homologene: 86792
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 24,748,862 bp
  • A to G, chromosome 1 at 65,165,136 bp
  • G to A, chromosome 1 at 69,539,097 bp
  • A to G, chromosome 1 at 131,846,587 bp
  • A to T, chromosome 1 at 180,327,225 bp
  • T to A, chromosome 1 at 180,669,198 bp
  • A to G, chromosome 2 at 25,363,349 bp
  • A to G, chromosome 2 at 34,856,488 bp
  • C to G, chromosome 2 at 121,363,629 bp
  • T to A, chromosome 2 at 157,283,596 bp
  • T to C, chromosome 2 at 181,029,460 bp
  • T to A, chromosome 3 at 69,008,110 bp
  • T to A, chromosome 3 at 103,178,424 bp
  • C to A, chromosome 3 at 106,388,752 bp
  • T to A, chromosome 4 at 45,881,455 bp
  • T to A, chromosome 4 at 144,618,028 bp
  • T to C, chromosome 5 at 24,403,109 bp
  • T to C, chromosome 5 at 90,604,118 bp
  • T to A, chromosome 5 at 104,498,506 bp
  • T to C, chromosome 5 at 111,420,326 bp
  • C to T, chromosome 5 at 123,819,057 bp
  • T to C, chromosome 5 at 137,529,192 bp
  • A to T, chromosome 6 at 8,667,257 bp
  • A to T, chromosome 7 at 20,101,945 bp
  • T to C, chromosome 7 at 100,507,419 bp
  • C to T, chromosome 7 at 107,425,296 bp
  • C to A, chromosome 7 at 120,873,290 bp
  • T to C, chromosome 7 at 143,847,423 bp
  • T to A, chromosome 9 at 59,868,184 bp
  • C to T, chromosome 9 at 75,344,514 bp
  • A to C, chromosome 9 at 108,579,723 bp
  • T to C, chromosome 10 at 77,938,353 bp
  • A to T, chromosome 10 at 129,186,849 bp
  • T to C, chromosome 11 at 44,560,088 bp
  • C to T, chromosome 11 at 46,574,606 bp
  • A to T, chromosome 11 at 54,337,189 bp
  • G to T, chromosome 11 at 61,369,261 bp
  • A to G, chromosome 11 at 86,278,931 bp
  • T to C, chromosome 11 at 98,554,758 bp
  • C to A, chromosome 11 at 99,864,586 bp
  • A to G, chromosome 12 at 84,058,950 bp
  • C to T, chromosome 13 at 116,876,580 bp
  • T to G, chromosome 14 at 31,735,065 bp
  • T to C, chromosome 14 at 70,604,979 bp
  • A to T, chromosome 15 at 36,162,095 bp
  • A to G, chromosome 15 at 64,699,285 bp
  • A to T, chromosome 15 at 79,299,142 bp
  • A to T, chromosome 16 at 96,315,509 bp
  • T to A, chromosome 18 at 24,615,210 bp
  • T to A, chromosome 18 at 49,877,697 bp
  • T to C, chromosome 18 at 84,561,044 bp
  • A to G, chromosome 19 at 9,992,103 bp
  • T to C, chromosome 19 at 36,086,990 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5633 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043284-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.