Strain Name:
C57BL/6J-MtgxR5650Btlr/Mmmh
Stock Number:
043296-MU
Citation ID:
RRID:MMRRC_043296-MU
Other Names:
R5650 (G1)
Major Collection:

Gene Information

Zmpste24
Name: zinc metallopeptidase, STE24
Synonyms: A530043O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230709
Homologene: 4277
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75560
Homologene: 38779
Fgr
Name: FGR proto-oncogene, Src family tyrosine kinase
Synonyms: Ali18, Mhdaali18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14191
HGNC: HGNC:3697
Homologene: 3842
Cdr2
Name: cerebellar degeneration-related 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12585
HGNC: HGNC:1799
Homologene: 7262
Mip
Name: major intrinsic protein of lens fiber
Synonyms: MIP26, Aqp0, Svl, Lop, lens opacity, shrivelled, aquaporin 0, Cts
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17339
HGNC: HGNC:7103
Homologene: 40627
Lgals9
Name: lectin, galactose binding, soluble 9
Synonyms: LGALS35, galectin-9, gal-9, Lgals5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16859
Homologene: 134662
Hspa4
Name: heat shock protein 4
Synonyms: APG-2, Hsp70RY, Hsp110, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Tcf12
Name: transcription factor 12
Synonyms: ME1, ALF1, HEB, HTF4, HTF-4, REB, bHLHb20, HEBAlt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21406
Homologene: 40774
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: 1190005L06Rik, A730023M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68925
Homologene: 32269
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76464
Homologene: 44890
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77087
Homologene: 69134
Helz
Name: helicase with zinc finger domain
Synonyms: 9630002H22Rik, 9430093I07Rik, 3110078M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78455
Homologene: 8918
Dlgap5
Name: DLG associated protein 5
Synonyms: Hurp, C86398, Dlg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218977
Homologene: 8840
Hat1
Name: histone aminotransferase 1
Synonyms: 2410071B14Rik, KAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107435
HGNC: HGNC:4821
Homologene: 2701
Slc25a17
Name: solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
Synonyms: PMP34, 34kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20524
VEGA: 15
Homologene: 4637
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Sucla2
Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit
Synonyms: 4930547K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20916
Homologene: 2856
Slc43a2
Name: solute carrier family 43, member 2
Synonyms: 7630402D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 215113
Homologene: 17555
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Kif7
Name: kinesin family member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16576
Homologene: 72555
Fam3d
Name: FAM3 metabolism regulating signaling molecule D
Synonyms: EF-7, 2310076N21Rik, Oit1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18300
VEGA: 14
Homologene: 16354
Zfp37
Name: zinc finger protein 37
Synonyms: Tzn, Zfp-37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22696
Homologene: 40682
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225659
VEGA: 18
Homologene: 11774
Naa35
Name: N(alpha)-acetyltransferase 35, NatC auxiliary subunit
Synonyms: A330027C19Rik, A330021G12Rik, C030004C14Rik, Mak10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78689
Homologene: 5781
Plekho2
Name: pleckstrin homology domain containing, family O member 2
Synonyms: Plekhq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102595
VEGA: 9
Homologene: 11870
Tubgcp3
Name: tubulin, gamma complex associated protein 3
Synonyms: Spc98p, GCP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 259279
Homologene: 4609
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: DRES9, RdgB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: 9430028L06Rik, 9030411M15Rik, Fam38b2, Piezo2, Fam38b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Cercam
Name: cerebral endothelial cell adhesion molecule
Synonyms: CerCAM, Ceecam1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99151
Homologene: 22954
Rab33b
Name: RAB33B, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19338
Homologene: 9642
Gsap
Name: gamma-secretase activating protein
Synonyms: A530088I07Rik, Pion
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212167
Homologene: 45504
Specc1
Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: 2810012G08Rik, B230396K10Rik, Cytsb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432572
Homologene: 45157
Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Synonyms: Oatp2, Slc21a5, Oatp1a4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28250
Homologene: 130782
Slc7a4
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224022
Homologene: 20883
Npepl1
Name: aminopeptidase-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228961
Homologene: 11647
Olfr904
Name: olfactory receptor 904
Synonyms: GA_x6K02T2PVTD-32156773-32157705, MOR167-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258797
VEGA: 9
Homologene: 133629
Fmo9
Name: flavin containing monooxygenase 9
Synonyms: 4831428F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240894
Homologene: 134192
Olfr50
Name: olfactory receptor 50
Synonyms: ID3, MOR136-6, GA_x6K02T2NLDC-33487752-33488690
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18350
Homologene: 74212
Tlr11
Name: toll-like receptor 11
Synonyms: LOC239081
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239081
Homologene: 77905
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Olfr63
Name: olfactory receptor 63
Synonyms: M4, MOR267-1, GA_x6K02T2NTC5-9778-8828
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258939
HGNC: HGNC:8174
Homologene: 130665
Coro1b
Name: coronin, actin binding protein 1B
Synonyms: coronin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 23789
HGNC: HGNC:2253
Homologene: 40790
Klhl33
Name: kelch-like 33
Synonyms: EG546611
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 546611
VEGA: 14
Homologene: 52385
Olfr290
Name: olfactory receptor 290
Synonyms: GA_x6K02T2NHDJ-11170115-11169168, MOR254-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258411
Homologene: 83130
Hsp90b1
Name: heat shock protein 90, beta (Grp94), member 1
Synonyms: ERp99, GRP94, tumor rejection antigen (gp96) 1, gp96, Tra-1, endoplasmin, Tra1, Targ2, 90 kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22027
Homologene: 2476
Zbtb7a
Name: zinc finger and BTB domain containing 7a
Synonyms: Lrf, 9030619K07Rik, 9130006G12Rik, FBI-1, Zbtb7, Pokemon, Leukemia/lymphoma Related Factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16969
Homologene: 7820
Gabrd
Name: gamma-aminobutyric acid (GABA) A receptor, subunit delta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14403
HGNC: HGNC:4084
Homologene: 55489
Tmem41b
Name: transmembrane protein 41B
Synonyms: 1500031M19Rik, D7Ertd70e, 1500015G02Rik, D7Ertd743e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233724
Homologene: 42740
Oxct1
Name: 3-oxoacid CoA transferase 1
Synonyms: 2610008O03Rik, Scot-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67041
HGNC: HGNC:8527
Homologene: 377
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192652
Homologene: 13983
Serpina1b
Name: serine (or cysteine) preptidase inhibitor, clade A, member 1B
Synonyms: PI2, D12Ucla2, Spi1-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20701
HGNC: HGNC:8941
Homologene: 20103
Sowahc
Name: sosondowah ankyrin repeat domain family member C
Synonyms: C820004L04Rik, Ankrd57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268301
Homologene: 49723
H4c4
Name: H4 clustered histone 4
Synonyms: Hist1h4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319156
HGNC: HGNC:4781
Homologene: 134481
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 166,663,446 bp
  • C to T, chromosome 2 at 29,881,815 bp
  • T to A, chromosome 2 at 36,793,265 bp
  • T to C, chromosome 2 at 71,434,034 bp
  • T to A, chromosome 2 at 119,081,550 bp
  • T to C, chromosome 2 at 119,773,850 bp
  • T to C, chromosome 2 at 174,121,536 bp
  • T to C, chromosome 3 at 51,493,416 bp
  • A to G, chromosome 4 at 32,667,467 bp
  • T to C, chromosome 4 at 62,191,765 bp
  • T to A, chromosome 4 at 121,082,877 bp
  • T to G, chromosome 4 at 133,000,222 bp
  • A to T, chromosome 4 at 155,388,624 bp
  • A to G, chromosome 5 at 21,251,053 bp
  • C to T, chromosome 5 at 110,695,952 bp
  • T to C, chromosome 6 at 85,620,271 bp
  • T to A, chromosome 6 at 141,809,394 bp
  • C to T, chromosome 7 at 79,710,979 bp
  • T to A, chromosome 7 at 84,916,418 bp
  • A to G, chromosome 7 at 109,974,865 bp
  • A to G, chromosome 7 at 120,958,336 bp
  • A to G, chromosome 8 at 12,648,670 bp
  • T to C, chromosome 8 at 122,887,397 bp
  • A to T, chromosome 9 at 38,464,727 bp
  • T to C, chromosome 9 at 65,556,736 bp
  • A to T, chromosome 9 at 71,885,302 bp
  • G to T, chromosome 9 at 119,143,594 bp
  • GGGAGGAGGAGGAGGAGGAGGAGGAGGA to GGGAGGAGGAGGAGGAGGAGGAGGA, chromosome 10 at 59,223,491 bp
  • A to G, chromosome 10 at 81,145,049 bp
  • G to A, chromosome 10 at 86,693,503 bp
  • A to T, chromosome 10 at 128,226,065 bp
  • T to C, chromosome 11 at 53,265,092 bp
  • T to C, chromosome 11 at 62,117,967 bp
  • T to A, chromosome 11 at 75,444,748 bp
  • T to C, chromosome 11 at 75,545,807 bp
  • T to A, chromosome 11 at 78,973,154 bp
  • T to A, chromosome 11 at 107,595,146 bp
  • T to A, chromosome 12 at 103,728,435 bp
  • A to T, chromosome 13 at 23,581,795 bp
  • G to A, chromosome 13 at 59,622,866 bp
  • A to T, chromosome 14 at 8,357,142 bp
  • C to T, chromosome 14 at 47,411,739 bp
  • C to T, chromosome 14 at 50,361,201 bp
  • A to G, chromosome 14 at 50,891,828 bp
  • A to G, chromosome 14 at 73,591,129 bp
  • A to T, chromosome 14 at 101,898,674 bp
  • T to A, chromosome 15 at 4,142,850 bp
  • A to T, chromosome 15 at 81,329,176 bp
  • G to T, chromosome 16 at 17,575,684 bp
  • A to T, chromosome 17 at 33,268,884 bp
  • T to A, chromosome 18 at 63,011,721 bp
  • A to T, chromosome 18 at 67,625,066 bp
  • C to A, chromosome 19 at 4,103,319 bp
  • C to T, chromosome 19 at 4,150,611 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5650 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043296-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.