Strain Name:
C57BL/6J-MtgxR5653Btlr/Mmmh
Stock Number:
043299-MU
Citation ID:
RRID:MMRRC_043299-MU
Other Names:
R5653 (G1)
Major Collection:

Strain Information

Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: Wbscr9, WSTF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: qkf, querkopf, Morf, B130044K16Rik, monocytic leukemia, Myst4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54169
Homologene: 136480
Dnm1l
Name: dynamin 1-like
Synonyms: 6330417M19Rik, Drp1, python, Dnmlp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Gtf2ird1
Name: general transcription factor II I repeat domain-containing 1
Synonyms: WBSCR11, Cream1, GTF3, MusTRD1, binding factor for early enhancer, BEN, ESTM9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57080
HGNC: HGNC:4661
Homologene: 4158
Bard1
Name: BRCA1 associated RING domain 1
Synonyms: ENSMUSG00000060893, ENSMUSG00000073653
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12021
HGNC: HGNC:952
Homologene: 400
Cacnb1
Name: calcium channel, voltage-dependent, beta 1 subunit
Synonyms: Cchlb1, Cchb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12295
HGNC: HGNC:1401
Homologene: 20186
Pcsk9
Name: proprotein convertase subtilisin/kexin type 9
Synonyms: Narc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100102
Homologene: 17790
Ddias
Name: DNA damage-induced apoptosis suppressor
Synonyms: noxin, 4632434I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74041
Homologene: 51655
Rspry1
Name: ring finger and SPRY domain containing 1
Synonyms: 4930470D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67610
Homologene: 12164
Txnrd3
Name: thioredoxin reductase 3
Synonyms: TR2, Tgr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232223
Homologene: 60033
Capza2
Name: capping actin protein of muscle Z-line subunit alpha 2
Synonyms: Cappa2, 1110053K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12343
HGNC: HGNC:1490
Homologene: 55956
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231214
Homologene: 18159
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: B230343B06Rik, Narg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 93697
Homologene: 11618
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Bmp1
Name: bone morphogenetic protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12153
VEGA: 14
HGNC: HGNC:1067
Homologene: 55955
Pcbp2
Name: poly(rC) binding protein 2
Synonyms: alphaCP-2, Hnrpx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18521
VEGA: 15
HGNC: HGNC:8648
Homologene: 74536
Dnajc10
Name: DnaJ heat shock protein family (Hsp40) member C10
Synonyms: JPDI, D2Ertd706e, 1200006L06Rik, ERdj5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66861
Homologene: 10358
Egfr
Name: epidermal growth factor receptor
Synonyms: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Wa5, 9030024J15Rik, Errb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Ablim2
Name: actin-binding LIM protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231148
Homologene: 82366
Ddr1
Name: discoidin domain receptor family, member 1
Synonyms: CD167a, Cak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12305
HGNC: HGNC:2730
Homologene: 68212
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: FIC1, Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: 9930021J17Rik, Fam160a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229488
Homologene: 85149
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: osteoclastogenesis inhibitory factor, OCIF, OPG, Opg, TR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Tubgcp6
Name: tubulin, gamma complex associated protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328580
Homologene: 32477
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Lrrc43
Name: leucine rich repeat containing 43
Synonyms: LOC381741
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381741
Homologene: 17662
Galnt11
Name: polypeptide N-acetylgalactosaminyltransferase 11
Synonyms: E430002F06Rik, A430075I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231050
Homologene: 11126
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Kif9
Name: kinesin family member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16578
Homologene: 65620
Tril
Name: TLR4 interactor with leucine-rich repeats
Synonyms: 1200009O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66873
Homologene: 69404
Kcnq4
Name: potassium voltage-gated channel, subfamily Q, member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 60613
HGNC: HGNC:6298
Homologene: 78107
Entpd7
Name: ectonucleoside triphosphate diphosphohydrolase 7
Synonyms: LALP1, 2810003F23Rik, 1810020C02Rik, Lysal2, 1810012B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 93685
Homologene: 122202
Lipe
Name: lipase, hormone sensitive
Synonyms: HSL, 4933403G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16890
HGNC: HGNC:6621
Homologene: 3912
Or2h15
Name: olfactory receptor family 2 subfamily H member 15
Synonyms: MOR256-49, GA_x6K02T2PSCP-2579687-2578746, Olfr132
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 257889
Homologene: 46430
Ccdc13
Name: coiled-coil domain containing 13
Synonyms: 2900041A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100502861
Homologene: 87213
Or5k14
Name: olfactory receptor family 5 subfamily K member 14
Synonyms: GA_x54KRFPKG5P-55091371-55090442, MOR184-7, Olfr177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258998
Homologene: 121500
Ptpre
Name: protein tyrosine phosphatase, receptor type, E
Synonyms: PTPe, PTPepsilon, RPTPepsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19267
HGNC: HGNC:9669
Homologene: 31387
Tnk1
Name: tyrosine kinase, non-receptor, 1
Synonyms: Kos1, Tnk1b, Tnk1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 83813
Homologene: 2966
Vmn1r210
Name: vomeronasal 1 receptor 210
Synonyms: V1rh10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171269
Homologene: 110880
Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: PRKN, Parkin, Park2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50873
HGNC: HGNC:8607
Homologene: 3355
Hspa1l
Name: heat shock protein 1-like
Synonyms: Msh5, Hsc70t, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15482
HGNC: HGNC:5234
Homologene: 135835
Edil3
Name: EGF-like repeats and discoidin I-like domains 3
Synonyms: Del1, developmental endothelial locus-1, Del-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13612
HGNC: HGNC:3173
Homologene: 21166
Prx
Name: periaxin
Synonyms: L-Periaxin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19153
Homologene: 76542
Or5p56
Name: olfactory receptor family 5 subfamily P member 56
Synonyms: GA_x6K02T2PBJ9-10319672-10320604, MOR204-1, Olfr477
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258928
Homologene: 27246
Or2ak5
Name: olfactory receptor family 2 subfamily AK member 5
Synonyms: GA_x6K02T2NKPP-692816-693736, MOR285-1, Olfr318
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258494
Homologene: 133825
Mrpl52
Name: mitochondrial ribosomal protein L52
Synonyms: 1110047B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68836
Homologene: 12286
Atp10d
Name: ATPase, class V, type 10D
Synonyms: IMAGE:1069176, D5Buc24e, 9830145H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231287
Vmn2r38
Name: vomeronasal 2, receptor 38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434110
Homologene: 113703
Tor3a
Name: torsin family 3, member A
Synonyms: Adir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 30935
Homologene: 23359
Gm37240
Name: predicted gene, 37240
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 71,031,429 bp
  • A to G, chromosome 1 at 156,656,510 bp
  • T to A, chromosome 2 at 80,349,368 bp
  • T to A, chromosome 2 at 98,664,051 bp
  • A to G, chromosome 3 at 84,497,795 bp
  • A to T, chromosome 3 at 85,722,501 bp
  • T to A, chromosome 4 at 106,458,916 bp
  • C to A, chromosome 4 at 120,702,411 bp
  • T to A, chromosome 5 at 25,248,858 bp
  • T to C, chromosome 5 at 35,883,412 bp
  • A to G, chromosome 5 at 43,722,462 bp
  • A to T, chromosome 5 at 72,264,067 bp
  • A to G, chromosome 5 at 123,499,580 bp
  • A to T, chromosome 5 at 134,410,967 bp
  • A to T, chromosome 5 at 135,209,097 bp
  • G to A, chromosome 6 at 17,654,113 bp
  • A to G, chromosome 6 at 32,517,616 bp
  • T to C, chromosome 6 at 53,817,985 bp
  • T to C, chromosome 6 at 89,654,085 bp
  • T to C, chromosome 7 at 9,097,765 bp
  • T to A, chromosome 7 at 25,398,408 bp
  • C to T, chromosome 7 at 27,517,604 bp
  • G to T, chromosome 7 at 92,858,729 bp
  • A to T, chromosome 7 at 107,990,385 bp
  • T to C, chromosome 7 at 135,653,943 bp
  • T to G, chromosome 8 at 94,636,611 bp
  • A to G, chromosome 9 at 69,428,380 bp
  • A to T, chromosome 9 at 110,524,931 bp
  • A to G, chromosome 9 at 121,798,787 bp
  • A to G, chromosome 10 at 123,026,094 bp
  • C to T, chromosome 11 at 16,911,617 bp
  • T to C, chromosome 11 at 55,310,316 bp
  • G to A, chromosome 11 at 58,720,251 bp
  • T to C, chromosome 11 at 65,849,980 bp
  • C to T, chromosome 11 at 69,853,585 bp
  • A to T, chromosome 11 at 98,009,279 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • T to A, chromosome 13 at 22,827,208 bp
  • A to T, chromosome 13 at 89,131,812 bp
  • A to G, chromosome 14 at 21,669,372 bp
  • T to C, chromosome 14 at 54,427,229 bp
  • T to A, chromosome 14 at 70,490,094 bp
  • A to T, chromosome 15 at 54,259,866 bp
  • C to T, chromosome 15 at 89,108,612 bp
  • C to T, chromosome 15 at 102,487,089 bp
  • A to G, chromosome 16 at 16,319,489 bp
  • T to A, chromosome 16 at 37,040,534 bp
  • A to G, chromosome 16 at 58,872,484 bp
  • C to T, chromosome 17 at 11,237,649 bp
  • T to C, chromosome 17 at 34,977,420 bp
  • C to T, chromosome 17 at 35,686,508 bp
  • T to A, chromosome 17 at 38,131,184 bp
  • A to G, chromosome 18 at 64,545,197 bp
  • C to T, chromosome 19 at 43,691,157 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5653 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043299-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.