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Strain Name:
C57BL/6J-MtgxR5654Btlr/Mmmh
Stock Number:
043300-MU
Citation ID:
RRID:MMRRC_043300-MU
Other Names:
R5654 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: Bravo, C030017F07Rik, C130076O07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Cs
Name: citrate synthase
Synonyms: Cis, 2610511A05Rik, 9030605P22Rik, ahl4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12974
VEGA: 10
HGNC: HGNC:2422
Homologene: 56073
Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Synonyms: Pck-1, PEPCK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18534
HGNC: HGNC:8724
Homologene: 1944
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107182
Homologene: 31978
Cpne1
Name: copine I
Synonyms: 1810028N16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 266692
HGNC: HGNC:2314
Homologene: 36501
Rab11fip3
Name: RAB11 family interacting protein 3 (class II)
Synonyms: Rab11-FIP3, D030060O14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 215445
Homologene: 49396
Cog3
Name: component of oligomeric golgi complex 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338337
VEGA: 14
Homologene: 5854
Esf1
Name: ESF1 nucleolar pre-rRNA processing protein homolog
Synonyms: 2610101J03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66580
Homologene: 5717
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Cyb5r4
Name: cytochrome b5 reductase 4
Synonyms: B5+B5R, b5/b5r, 2810034J18Rik, Ncb5or
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 266690
Homologene: 69207
Ipo9
Name: importin 9
Synonyms: 0710008K06Rik, Imp9
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226432
Homologene: 5874
Slc25a46
Name: solute carrier family 25, member 46
Synonyms: 1200007B05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67453
VEGA: 18
Homologene: 14518
Spag9
Name: sperm associated antigen 9
Synonyms: 4733401I23Rik, syd1, 4831406C20Rik, Mapk8ip4, JIP4, 3110018C07Rik, JLP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Fbxl18
Name: F-box and leucine-rich repeat protein 18
Synonyms: C330021B20Rik, B130019G13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231863
Homologene: 41603
Edaradd
Name: EDAR associated via death domain
Synonyms: 1810032E07Rik, 5830469M23Rik, EDAR (ectodysplasin-A receptor)-associated death domain
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171211
VEGA: 13
Homologene: 15430
Ube2s
Name: ubiquitin-conjugating enzyme E2S
Synonyms: E2-EPF, 6720465F12Rik, 0910001J09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77891
Homologene: 56676
Klk11
Name: kallikrein related-peptidase 11
Synonyms: TLSP, hippostasin, Prss20, 2310015I08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56538
HGNC: HGNC:6359
Homologene: 27048
Fcrl2
Name: Fc receptor like 2
Synonyms: 2810439C17Rik, IFGP2, Fcrh2, moFcRH2sc, Msr2, Fcrls
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80891
Homologene: 57117
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: lysyl hydroxylase 2, LH2, Plod-2, D530025C14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Marchf6
Name: membrane associated ring-CH-type finger 6
Synonyms: F830029L24Rik, March6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223455
VEGA: 15
Homologene: 4301
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Abcb6
Name: ATP-binding cassette, sub-family B member 6
Synonyms: 1200005B17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74104
HGNC: HGNC:47
Homologene: 11375
Ddr1
Name: discoidin domain receptor family, member 1
Synonyms: CD167a, Cak
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12305
HGNC: HGNC:2730
Homologene: 68212
Rpl5
Name: ribosomal protein L5
Synonyms: U21RNA, Ska23, Skam23Jus, Skax23
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503670
Homologene: 110649
Natd1
Name: N-acetyltransferase domain containing 1
Synonyms: F3-2, Gtlf3b, Gm16515
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 24083
Homologene: 11907
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: 9430028L06Rik, 9030411M15Rik, Fam38b2, Piezo2, Fam38b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 667742
Homologene: 49695
Or4k51
Name: olfactory receptor family 4 subfamily K member 51
Synonyms: GA_x6K02T2Q125-72805651-72806589, MOR248-5, Olfr1301
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258889
Homologene: 74057
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Uspl1
Name: ubiquitin specific peptidase like 1
Synonyms: E430026A01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231915
Homologene: 4235
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Per2
Name: period circadian clock 2
Synonyms: mPer2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18627
HGNC: HGNC:8846
Homologene: 7885
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100045792
Homologene: 46005
Cdhr2
Name: cadherin-related family member 2
Synonyms: LOC268663, Pcdh24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268663
Homologene: 134510
Mapk4
Name: mitogen-activated protein kinase 4
Synonyms: A330097D03Rik, Erk3-related, p63Mapk
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225724
HGNC: HGNC:6878
Homologene: 2058
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: SUR2B, SUR2A, Sur2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
Synonyms: 2700043D08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108037
VEGA: 10
Homologene: 133984
Or10a2
Name: olfactory receptor family 10 subfamily A member 2
Synonyms: GA_x6K02T2PBJ9-9453401-9454354, MOR263-2, P4, Olfr714
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259035
Homologene: 72055
Klhl32
Name: kelch-like 32
Synonyms: LOC384000, D4Ertd389e, 6430524H05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212390
Homologene: 14173
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Ppp1r15b
Name: protein phosphatase 1, regulatory subunit 15B
Synonyms: C530022L24Rik, 1810033K10Rik, CReP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108954
Homologene: 13134
Lamp1
Name: lysosomal-associated membrane protein 1
Synonyms: CD107a, Lamp-1, Perk
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16783
HGNC: HGNC:6499
Homologene: 4061
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Caskin2
Name: CASK-interacting protein 2
Synonyms: 1600028L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140721
Homologene: 32485
Or52a5
Name: olfactory receptor family 52 subfamily A member 5
Synonyms: 3'[b]2, MOR22-3, GA_x6K02T2PBJ9-6504436-6503489, Olfr68
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18369
Homologene: 130658
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: B430315C20Rik, Hisppd2a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 327655
Homologene: 49395
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: Sglt1, sodium glucose cotransporter 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20537
Homologene: 55456
Trappc3l
Name: trafficking protein particle complex 3 like
Synonyms: ENSMUSG00000071340, Bet3l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 692132
VEGA: 10
Homologene: 82663
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241633
Homologene: 133162
Pkdcc
Name: protein kinase domain containing, cytoplasmic
Synonyms: ESTM17, Vlk, MAd1, Adtk1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106522
Homologene: 18932
Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: PRKN, Parkin, Park2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50873
HGNC: HGNC:8607
Homologene: 3355
Tmem171
Name: transmembrane protein 171
Synonyms: LOC380863
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380863
Homologene: 18301
Mdp1
Name: magnesium-dependent phosphatase 1
Synonyms: 1810034K20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67881
VEGA: 14
Homologene: 5846
Iffo1
Name: intermediate filament family orphan 1
Synonyms: 4733401N06Rik, Iffo, A930037G23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320678
Homologene: 18706
Fam8a1
Name: family with sequence similarity 8, member A1
Synonyms: C78339
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97863
Homologene: 32301
Ido1
Name: indoleamine 2,3-dioxygenase 1
Synonyms: Ido, Indo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15930
HGNC: HGNC:6059
Homologene: 48082
Igfals
Name: insulin-like growth factor binding protein, acid labile subunit
Synonyms: ALS, Albs
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16005
VEGA: 17
HGNC: HGNC:5468
Homologene: 37987
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: acetyl-CoA synthetase 1, AceCS1, ACAS, Acas1, Acs1, Acas2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60525
Homologene: 6469
Klk1b24
Name: kallikrein 1-related peptidase b24
Synonyms: mGk-24, Klk24
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16617
Homologene: 68141
Or5m11b
Name: olfactory receptor family 5 subfamily M member 11B
Synonyms: GA_x6K02T2Q125-47454152-47455126, MOR198-1P, Olfr1029
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258154
Homologene: 73972
Vmn1r2
Name: vomeronasal 1 receptor 2
Synonyms: Gm11776
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100312470
Homologene: 128342
Mrgpra2a
Name: MAS-related GPR, member A2A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668727
Homologene: 79615
Mettl21e
Name: methyltransferase like 21E
Synonyms: LOC381340, 4832428D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 403183
Homologene: 19006
Snrnp35
Name: small nuclear ribonucleoprotein 35 (U11/U12)
Synonyms: 6330548G22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76167
Homologene: 31415
6330408A02Rik
Name:
Type: Gene
Species: Mouse
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 44,211,095 bp
  • T to C, chromosome 1 at 75,174,835 bp
  • C to T, chromosome 1 at 91,445,501 bp
  • C to T, chromosome 1 at 97,864,398 bp
  • C to T, chromosome 1 at 133,131,644 bp
  • A to T, chromosome 1 at 135,385,472 bp
  • A to G, chromosome 2 at 85,976,156 bp
  • T to A, chromosome 2 at 111,754,981 bp
  • G to A, chromosome 2 at 121,316,676 bp
  • G to A, chromosome 2 at 126,375,805 bp
  • T to C, chromosome 2 at 140,164,228 bp
  • T to C, chromosome 2 at 155,574,655 bp
  • A to G, chromosome 2 at 156,077,641 bp
  • T to A, chromosome 2 at 173,158,560 bp
  • A to C, chromosome 3 at 87,257,544 bp
  • T to C, chromosome 4 at 3,172,261 bp
  • C to T, chromosome 4 at 24,800,805 bp
  • A to G, chromosome 5 at 33,146,611 bp
  • T to A, chromosome 5 at 107,903,648 bp
  • T to C, chromosome 5 at 124,490,472 bp
  • A to G, chromosome 5 at 141,936,098 bp
  • A to G, chromosome 5 at 142,885,803 bp
  • T to C, chromosome 5 at 149,209,711 bp
  • G to T, chromosome 6 at 22,986,134 bp
  • A to G, chromosome 6 at 30,117,062 bp
  • T to G, chromosome 6 at 125,153,067 bp
  • G to A, chromosome 6 at 142,625,645 bp
  • T to C, chromosome 7 at 4,808,432 bp
  • G to A, chromosome 7 at 13,261,168 bp
  • T to A, chromosome 7 at 43,778,386 bp
  • A to T, chromosome 7 at 44,191,465 bp
  • A to G, chromosome 7 at 47,427,405 bp
  • A to C, chromosome 7 at 103,777,975 bp
  • G to A, chromosome 7 at 107,074,187 bp
  • G to A, chromosome 8 at 13,171,388 bp
  • C to T, chromosome 8 at 24,587,803 bp
  • G to T, chromosome 9 at 87,047,480 bp
  • A to G, chromosome 9 at 92,593,823 bp
  • C to T, chromosome 10 at 18,143,062 bp
  • T to A, chromosome 10 at 34,102,707 bp
  • T to A, chromosome 10 at 67,230,006 bp
  • T to C, chromosome 10 at 127,517,799 bp
  • G to A, chromosome 10 at 128,351,217 bp
  • T to C, chromosome 11 at 60,906,066 bp
  • C to T, chromosome 11 at 73,712,138 bp
  • T to A, chromosome 11 at 94,090,712 bp
  • T to C, chromosome 11 at 115,800,079 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • T to A, chromosome 12 at 13,583,475 bp
  • A to G, chromosome 12 at 44,564,058 bp
  • C to A, chromosome 13 at 12,478,280 bp
  • T to A, chromosome 13 at 46,674,338 bp
  • A to G, chromosome 13 at 54,736,536 bp
  • C to A, chromosome 13 at 98,692,066 bp
  • T to C, chromosome 14 at 33,107,618 bp
  • A to G, chromosome 14 at 55,659,008 bp
  • G to A, chromosome 14 at 75,724,799 bp
  • A to T, chromosome 15 at 31,485,936 bp
  • T to A, chromosome 15 at 89,521,326 bp
  • C to T, chromosome 17 at 11,237,649 bp
  • A to T, chromosome 17 at 24,881,465 bp
  • A to T, chromosome 17 at 26,016,064 bp
  • C to T, chromosome 17 at 35,686,508 bp
  • A to G, chromosome 17 at 83,215,908 bp
  • A to G, chromosome 18 at 31,583,240 bp
  • G to C, chromosome 18 at 63,145,091 bp
  • A to T, chromosome 18 at 73,970,294 bp
  • G to A, chromosome 18 at 89,048,432 bp
  • A to T, chromosome 19 at 36,983,615 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5654 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043300-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.