Strain Name:
C57BL/6J-MtgxR5689Btlr
Stock Number:
043322-MU
Citation ID:
RRID:MMRRC_043322-MU
Other Names:
R5689 (G1)
Major Collection:

Gene Information

Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: Sin, RPC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26939
Homologene: 14052
Pmel
Name: premelanosome protein
Synonyms: gp87, Si, D12S53Eh, D10H12S53E, Pmel17, gp100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20431
VEGA: 10
Homologene: 5048
Phf12
Name: PHD finger protein 12
Synonyms: 2410142K10Rik, PF1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268448
Homologene: 10841
Tnpo3
Name: transportin 3
Synonyms: D6Ertd313e, C430013M08Rik, 5730544L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320938
Homologene: 40848
Zfp638
Name: zinc finger protein 638
Synonyms: Zfml, Np220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18139
Homologene: 7447
Trpc4ap
Name: transient receptor potential cation channel, subfamily C, member 4 associated protein
Synonyms: Trrp4ap, D2Ertd113e, Trp4-associated protein TAP1, 4833429F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56407
Homologene: 9224
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, XAP8, Hbxap, C030033M12Rik, p325
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, Afadin, 5033403D15Rik, Mllt4, I-afadin, S-afadin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Rarb
Name: retinoic acid receptor, beta
Synonyms: RAR beta 2, Hap, RARbeta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218772
VEGA: 14
HGNC: HGNC:9865
Homologene: 68100
Rapsn
Name: receptor-associated protein of the synapse
Synonyms: 43kDa acetylcholine receptor-associated protein, Raps, rapsyn, Nraps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19400
HGNC: HGNC:9863
Homologene: 3708
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239250
VEGA: 14
Homologene: 12986
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: Lyt-4, CD45, B220, Ly-5, T200
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Dbx1
Name: developing brain homeobox 1
Synonyms: Mmox C, Dbx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13172
Homologene: 19002
Lifr
Name: LIF receptor alpha
Synonyms: A230075M04Rik, soluble differentiation-stimulating factor receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC2, D330044F14Rik, Dnchc2, m152Asp, m407Asp, 4432416O06Rik, DHC1b, D030010H02Rik, b2b414Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68187
Homologene: 32665
Aimp2
Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Synonyms: Jtv1, Aimp2(p38)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231872
Homologene: 4594
Eno4
Name: enolase 4
Synonyms: 6430537H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226265
Homologene: 18691
Lrch1
Name: leucine-rich repeats and calponin homology (CH) domain containing 1
Synonyms: Chdc1, 4832412D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380916
VEGA: 14
Homologene: 32244
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216742
Homologene: 28173
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239102
Homologene: 52657
Uts2
Name: urotensin 2
Synonyms: Ucn2, urotensin II precursor, prepro-UII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 24111
Homologene: 4939
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: FIC1, Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Slc35e2
Name: solute carrier family 35, member E2
Synonyms: A530082C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320541
Homologene: 84987
Ttn
Name: titin
Synonyms: D830007G01Rik, connectin, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Vmn2r116
Name: vomeronasal 2, receptor 116
Synonyms: EG619697, V2Rp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 619697
Homologene: 86604
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76295
Homologene: 32919
Lnx2
Name: ligand of numb-protein X 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140887
Homologene: 17737
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Rev, Sez4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D130016K21Rik, 4732458A06Rik, 9430063L05Rik, D3Bwg1078e, Usmg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 83679
Homologene: 66961
Cmpk2
Name: cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Synonyms: TDKI, Tyki, 1200004E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22169
VEGA: 12
Homologene: 10748
Flnc
Name: filamin C, gamma
Synonyms: actin binding protein 280, 1110055E19Rik, Fln2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Trim50
Name: tripartite motif-containing 50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215061
Homologene: 14548
Osgin1
Name: oxidative stress induced growth inhibitor 1
Synonyms: 1700012B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71839
Homologene: 16325
Gcnt1
Name: glucosaminyl (N-acetyl) transferase 1, core 2
Synonyms: 5630400D21Rik, IGnT, beta-1, 6-N-acetylglucosaminyltransferase, C2 GlcNAcT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14537
HGNC: HGNC:4203
Homologene: 37486
Smg8
Name: smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms: 1200011M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74133
Homologene: 32393
Galc
Name: galactosylceramidase
Synonyms: Gacy, 2310068B06Rik, galactocerebrosidase, A930008M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14420
VEGA: 12
HGNC: HGNC:4115
Homologene: 124
Vmn1r52
Name: vomeronasal 1 receptor 52
Synonyms: VN3, V1ra7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113849
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 1700084G18Rik, 2310039H16Rik, 3110007G05Rik, B130050I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 213027
Homologene: 134635
Cfb
Name: complement factor B
Synonyms: Factor B, alternative-complement pathway C3/C5 convertase, H2-Bf, Bf, FB, B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14962
HGNC: HGNC:1037
Homologene: 1292
Vps16
Name: VSP16 CORVET/HOPS core subunit
Synonyms: 1810074M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80743
Homologene: 7116
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: sut, xCT, System xc, 9930009M05Rik, xc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26570
Homologene: 22684
Grin3b
Name: glutamate receptor, ionotropic, NMDA3B
Synonyms: NR3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 170483
Homologene: 15606
Dnajc25
Name: DnaJ heat shock protein family (Hsp40) member C25
Synonyms: 2010203O07Rik, 2010109C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72429
Homologene: 37883
Gask1a
Name: golgi associated kinase 1A
Synonyms: Fam198a, C730027P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245050
VEGA: 9
Homologene: 18620
Gstm5
Name: glutathione S-transferase, mu 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14866
HGNC: HGNC:4635
Homologene: 658
Aqp7
Name: aquaporin 7
Synonyms: AQPap, AQP7L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11832
HGNC: HGNC:640
Homologene: 48000
Rnf146
Name: ring finger protein 146
Synonyms: Iduna, 2610509H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68031
Homologene: 12227
Slc5a10
Name: solute carrier family 5 (sodium/glucose cotransporter), member 10
Synonyms: SGLT5, C330021F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 109342
Homologene: 65037
Cypt4
Name: cysteine-rich perinuclear theca 4
Synonyms: 1700009B20Rik, Ckt1r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235067
VEGA: 9
Olfr1512
Name: olfactory receptor 1512
Synonyms: GA_x6K02T2RJGY-622120-623061, MOR223-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258424
HGNC: HGNC:8171
Homologene: 27165
Ilk
Name: integrin linked kinase
Synonyms: ESTM24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16202
HGNC: HGNC:6040
Homologene: 3318
Gm26996
Name: predicted gene, 26996
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Gm5321
Name: predicted gene 5321
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384525
Pcdhga7
Name: protocadherin gamma subfamily A, 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93715
HGNC: HGNC:8705
Homologene: 36377
Trav7d-4
Name: T cell receptor alpha variable 7D-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 382180
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 24,029,053 bp
  • A to G, chromosome 1 at 53,405,698 bp
  • A to G, chromosome 1 at 138,117,777 bp
  • T to A, chromosome 2 at 76,788,276 bp
  • T to C, chromosome 2 at 91,035,924 bp
  • C to T, chromosome 2 at 130,439,091 bp
  • C to G, chromosome 2 at 155,671,035 bp
  • G to T, chromosome 3 at 35,834,352 bp
  • C to G, chromosome 3 at 50,372,331 bp
  • A to T, chromosome 3 at 97,692,367 bp
  • T to C, chromosome 3 at 107,896,665 bp
  • G to A, chromosome 4 at 41,035,510 bp
  • A to G, chromosome 4 at 59,017,716 bp
  • A to T, chromosome 4 at 150,999,108 bp
  • C to T, chromosome 4 at 155,610,026 bp
  • A to T, chromosome 5 at 135,353,662 bp
  • T to C, chromosome 5 at 143,906,571 bp
  • A to T, chromosome 5 at 147,029,151 bp
  • G to A, chromosome 6 at 29,441,592 bp
  • T to C, chromosome 6 at 29,571,064 bp
  • T to A, chromosome 6 at 73,021,227 bp
  • T to C, chromosome 6 at 83,929,072 bp
  • T to C, chromosome 6 at 90,179,250 bp
  • T to C, chromosome 6 at 130,578,295 bp
  • A to T, chromosome 7 at 6,019,269 bp
  • A to G, chromosome 7 at 49,632,771 bp
  • GC to GCGGCGGCGCC, chromosome 7 at 97,579,934 bp
  • C to A, chromosome 7 at 105,741,650 bp
  • C to A, chromosome 7 at 120,940,689 bp
  • C to T, chromosome 8 at 4,205,460 bp
  • G to T, chromosome 8 at 88,324,784 bp
  • A to G, chromosome 8 at 119,444,989 bp
  • C to A, chromosome 9 at 7,169,689 bp
  • T to C, chromosome 9 at 24,625,246 bp
  • T to C, chromosome 9 at 121,965,688 bp
  • T to C, chromosome 10 at 29,347,804 bp
  • T to C, chromosome 10 at 39,794,958 bp
  • T to C, chromosome 10 at 79,974,631 bp
  • A to G, chromosome 10 at 128,716,301 bp
  • T to C, chromosome 11 at 54,502,289 bp
  • C to T, chromosome 11 at 61,707,884 bp
  • T to A, chromosome 11 at 78,023,725 bp
  • A to G, chromosome 11 at 87,085,123 bp
  • A to T, chromosome 12 at 26,469,767 bp
  • G to T, chromosome 12 at 98,212,986 bp
  • T to A, chromosome 14 at 16,434,177 bp
  • C to T, chromosome 14 at 52,372,757 bp
  • G to A, chromosome 14 at 52,770,194 bp
  • T to C, chromosome 14 at 55,073,903 bp
  • T to C, chromosome 14 at 74,786,324 bp
  • C to T, chromosome 14 at 110,752,126 bp
  • A to G, chromosome 15 at 7,184,804 bp
  • T to C, chromosome 17 at 13,855,359 bp
  • A to G, chromosome 17 at 23,397,719 bp
  • T to A, chromosome 17 at 34,861,794 bp
  • C to A, chromosome 18 at 37,716,683 bp
  • C to T, chromosome 18 at 64,564,537 bp
  • T to A, chromosome 19 at 17,329,404 bp
  • T to A, chromosome 19 at 58,970,656 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5689 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043322-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.