Strain Name:
C57BL/6J-MtgxR5705Btlr
Stock Number:
043330-MU
Citation ID:
RRID:MMRRC_043330-MU
Other Names:
R5705 (G1)
Major Collection:

Gene Information

Pald1
Name: phosphatase domain containing, paladin 1
Synonyms: X99384, paladin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 27355
VEGA: 10
Homologene: 8453
Neurod4
Name: neurogenic differentiation 4
Synonyms: MATH-3, Math3, Atoh3, bHLHa4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11923
VEGA: 10
Homologene: 7234
Tm9sf4
Name: transmembrane 9 superfamily protein member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99237
Homologene: 21620
Klhdc4
Name: kelch domain containing 4
Synonyms: G430025P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234825
Homologene: 69234
Ago1
Name: argonaute RISC catalytic subunit 1
Synonyms: argonaute 1, Eif2c1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 236511
HGNC: HGNC:3262
Homologene: 81826
Ppp1r10
Name: protein phosphatase 1, regulatory subunit 10
Synonyms: 2610025H06Rik, D17Ertd808e, PNUTS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 52040
HGNC: HGNC:9284
Homologene: 2033
Wwc1
Name: WW, C2 and coiled-coil domain containing 1
Synonyms: Kibra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 211652
Homologene: 69180
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: 128kDa, D630020H17Rik, RPA116, RPA2, Rpo1-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20017
Homologene: 7133
Tlr4
Name: toll-like receptor 4
Synonyms: Rasl2-8, Lps, lipopolysaccharide response
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21898
Homologene: 41317
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 665775
Homologene: 45109
Pisd
Name: phosphatidylserine decarboxylase
Synonyms: 9030221M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320951
HGNC: HGNC:8999
Homologene: 81653
Igsf9
Name: immunoglobulin superfamily, member 9
Synonyms: Dasm1, NRT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 93842
Homologene: 10815
Pcmt1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
Synonyms: PIMT, protein carboxyl methyltransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18537
HGNC: HGNC:8728
Homologene: 135759
Rsrp1
Name: arginine/serine rich protein 1
Synonyms: D4Ucla2, D4Wsu53e, 2700043I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 27981
Cnih4
Name: cornichon family AMPA receptor auxiliary protein 4
Synonyms: D530030D03Rik, E430023H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98417
Homologene: 5932
Ndufs1
Name: NADH:ubiquinone oxidoreductase core subunit S1
Synonyms: 5830412M15Rik, 9930026A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227197
HGNC: HGNC:7707
Homologene: 3670
Esyt3
Name: extended synaptotagmin-like protein 3
Synonyms: D9Ertd280e, Fam62c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 272636
Homologene: 18626
Syk
Name: spleen tyrosine kinase
Synonyms: Sykb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 20963
Homologene: 2390
Ldb3
Name: LIM domain binding 3
Synonyms: cypher, ZASP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 24131
VEGA: 14
Homologene: 134626
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: AS250, RGC2, A230067G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241694
Homologene: 28131
Glp2r
Name: glucagon-like peptide 2 receptor
Synonyms: GLP-2, 9530092J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 93896
HGNC: HGNC:4325
Homologene: 3132
Eps8l1
Name: EPS8-like 1
Synonyms: 4632407K17Rik, EPS8R1, 2310051G19Rik, DRC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67425
Homologene: 15767
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: A330009G12Rik, LOC381663, Sec63d1, Mer3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 330149
Homologene: 87103
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 434341
Homologene: 88935
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 51938
Homologene: 12149
Ctse
Name: cathepsin E
Synonyms: A430072O03Rik, C920004C08Rik, CE, CatE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13034
HGNC: HGNC:2530
Homologene: 37551
Eps8l3
Name: EPS8-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99662
Homologene: 15878
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: 5730414M22Rik, BKCa, Slo, BK channel alpha subunit, MaxiK, Slo1, mSlo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Trim30b
Name: tripartite motif-containing 30B
Synonyms: A530023O14Rik, Trim30-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244183
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Mxr2, Abcp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 27405
Homologene: 86845
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Mer, Nyk, nmf12, Eyk, Tyro 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Aurkb
Name: aurora kinase B
Synonyms: Stk5, aurora B, Stk12, AIRK2, STK-1, IPL1, Aik2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20877
Homologene: 55807
Tspan33
Name: tetraspanin 33
Synonyms: Penumbra, 1300010A20Rik, Pen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232670
Homologene: 8213
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Fam196b, Gm6041
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 574403
VEGA: 11
Homologene: 107175
Setdb2
Name: SET domain, bifurcated 2
Synonyms: KMT1F, LOC239122
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239122
Homologene: 12903
Use1
Name: unconventional SNARE in the ER 1 homolog (S. cerevisiae)
Synonyms: Q-SNARE, 2010315L10Rik, mED2, 5730403H22Rik, D12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 67023
Homologene: 10214
Hs3st2
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Synonyms: 6430516N12Rik, A830061E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 195646
HGNC: HGNC:5195
Homologene: 21220
Dtx2
Name: deltex 2, E3 ubiquitin ligase
Synonyms: 2610524D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74198
Homologene: 56904
Abca7
Name: ATP-binding cassette, sub-family A (ABC1), member 7
Synonyms: Abc51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Fam161a
Name: family with sequence similarity 161, member A
Synonyms: 4930430E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 73873
Homologene: 19131
Plcxd3
Name: phosphatidylinositol-specific phospholipase C, X domain containing 3
Synonyms: B130016O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239318
Homologene: 45574
Arhgap4
Name: Rho GTPase activating protein 4
Synonyms: Rgc1, c1, A530015A20Rik, A130009C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 171207
HGNC: HGNC:674
Homologene: 20403
Ccdc17
Name: coiled-coil domain containing 17
Synonyms: 1100001F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 622665
Homologene: 77410
Gnl1
Name: guanine nucleotide binding protein-like 1
Synonyms: Gna-rs1, Gnal1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14670
HGNC: HGNC:4413
Homologene: 3862
Calhm5
Name: calcium homeostasis modulator family member 5
Synonyms: Fam26e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 103511
VEGA: 10
Homologene: 17807
Zfp263
Name: zinc finger protein 263
Synonyms: mFPM315, 1200014J04Rik, NT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74120
Homologene: 4197
Srcin1
Name: SRC kinase signaling inhibitor 1
Synonyms: p140Cap, P140
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 56013
Homologene: 10324
Cyp2a22
Name: cytochrome P450, family 2, subfamily a, polypeptide 22
Synonyms: EG233005
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233005
Homologene: 69128
Ctsr
Name: cathepsin R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56835
VEGA: 13
Homologene: 75127
Defb23
Name: defensin beta 23
Synonyms: EG629114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 629114
Homologene: 83411
Tsga13
Name: testis specific gene A13
Synonyms: 1700023D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 116732
Homologene: 76446
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 63,147,158 bp
  • C to A, chromosome 1 at 131,664,374 bp
  • T to C, chromosome 1 at 172,494,771 bp
  • A to G, chromosome 1 at 181,153,735 bp
  • T to C, chromosome 1 at 184,730,865 bp
  • C to A, chromosome 2 at 128,771,401 bp
  • A to T, chromosome 2 at 129,105,351 bp
  • A to G, chromosome 2 at 146,449,273 bp
  • C to T, chromosome 2 at 152,459,284 bp
  • T to A, chromosome 2 at 153,182,458 bp
  • T to C, chromosome 3 at 33,816,937 bp
  • C to A, chromosome 3 at 107,891,264 bp
  • T to A, chromosome 4 at 66,833,980 bp
  • C to T, chromosome 4 at 116,596,869 bp
  • T to C, chromosome 4 at 126,448,794 bp
  • T to C, chromosome 4 at 134,924,020 bp
  • C to T, chromosome 5 at 32,737,363 bp
  • T to A, chromosome 5 at 41,817,002 bp
  • G to A, chromosome 5 at 104,968,170 bp
  • T to C, chromosome 5 at 106,911,453 bp
  • C to A, chromosome 5 at 136,010,295 bp
  • A to G, chromosome 6 at 29,717,233 bp
  • A to G, chromosome 6 at 30,900,016 bp
  • T to C, chromosome 7 at 4,470,035 bp
  • T to C, chromosome 7 at 26,939,215 bp
  • T to A, chromosome 7 at 104,357,577 bp
  • T to C, chromosome 7 at 121,393,082 bp
  • G to T, chromosome 8 at 71,369,687 bp
  • T to A, chromosome 8 at 94,475,757 bp
  • A to G, chromosome 8 at 121,804,993 bp
  • A to G, chromosome 9 at 99,318,207 bp
  • T to C, chromosome 10 at 7,638,190 bp
  • A to T, chromosome 10 at 34,095,993 bp
  • A to G, chromosome 10 at 61,323,297 bp
  • T to C, chromosome 10 at 80,015,442 bp
  • A to G, chromosome 10 at 130,271,402 bp
  • T to A, chromosome 11 at 23,028,869 bp
  • A to G, chromosome 11 at 34,404,349 bp
  • T to C, chromosome 11 at 35,876,596 bp
  • A to G, chromosome 11 at 67,709,739 bp
  • T to A, chromosome 11 at 69,048,815 bp
  • A to G, chromosome 11 at 97,548,951 bp
  • A to G, chromosome 13 at 52,611,047 bp
  • A to G, chromosome 13 at 61,161,264 bp
  • A to T, chromosome 14 at 24,003,771 bp
  • T to C, chromosome 14 at 34,577,029 bp
  • T to G, chromosome 14 at 59,423,365 bp
  • C to A, chromosome 15 at 4,517,194 bp
  • C to T, chromosome 16 at 3,746,454 bp
  • T to C, chromosome 17 at 35,929,489 bp
  • G to A, chromosome 17 at 35,981,600 bp
  • G to A, chromosome X at 73,906,817 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5705 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043330-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.