Strain Name:
C57BL/6J-MtgxR5708Btlr
Stock Number:
043333-MU
Citation ID:
RRID:MMRRC_043333-MU
Other Names:
R5708 (G1)
Major Collection:

Strain Information

Zfp930
Name: zinc finger protein 930
Synonyms: zinc finger protein, D10627
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234358
Rgs12
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71729
HGNC: HGNC:9994
Homologene: 2195
Srfbp1
Name: serum response factor binding protein 1
Synonyms: 2810036K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67222
VEGA: 18
Homologene: 12101
Asxl2
Name: ASXL transcriptional regulator 2
Synonyms: 4930556B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75302
Homologene: 10102
Setd2
Name: SET domain containing 2
Synonyms: 4921524K10Rik, KMT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235626
Homologene: 56493
Rarb
Name: retinoic acid receptor, beta
Synonyms: RARbeta2, RAR beta 2, Hap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218772
VEGA: 14
HGNC: HGNC:9865
Homologene: 68100
Furin
Name: furin (paired basic amino acid cleaving enzyme)
Synonyms: Fur, PACE, SPC1, Pcsk3, 9130404I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18550
HGNC: HGNC:8568
Homologene: 1930
Gkn2
Name: gastrokine 2
Synonyms: 1810036H07Rik, Bricd1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66284
Homologene: 11942
Tsc1
Name: TSC complex subunit 1
Synonyms: hamartin, tuberous sclerosis 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64930
Homologene: 314
Sil1
Name: SIL1 nucleotide exchange factor
Synonyms: 1810057E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 81500
VEGA: 18
Homologene: 32544
Cfap299
Name: cilia and flagella associated protein 299
Synonyms: 1700007G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75784
Homologene: 51893
Sec31b
Name: Sec31 homolog B (S. cerevisiae)
Synonyms: LOC240667, Sec31l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240667
Homologene: 56708
Kcnj11
Name: potassium inwardly rectifying channel, subfamily J, member 11
Synonyms: Kir6.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16514
HGNC: HGNC:6257
Homologene: 441
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, 1500031A17Rik, C530008O15Rik, C630040K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 665113
Homologene: 77943
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233651
Homologene: 2771
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Zscan18
Name: zinc finger and SCAN domain containing 18
Synonyms: EG232875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232875
Homologene: 122136
C7
Name: complement component 7
Synonyms: LOC383055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109828
VEGA: 15
HGNC: HGNC:1346
Homologene: 489
Cdkl4
Name: cyclin-dependent kinase-like 4
Synonyms: LOC381113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381113
VEGA: 17
Homologene: 28725
Megf8
Name: multiple EGF-like-domains 8
Synonyms: Egfl4, b2b288Clo, b2b1702Clo, m687Ddg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
EU599041
Name: expressed sequence EU599041
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100170401
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215772
Homologene: 100289
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268527
Homologene: 8780
Or11g25
Name: olfactory receptor family 11 subfamily G member 25
Synonyms: GA_x6K02T2PMLR-6197851-6198786, MOR106-10, MOR106-15, Olfr741
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258233
Kcnh6
Name: potassium voltage-gated channel, subfamily H (eag-related), member 6
Synonyms: m-erg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192775
Homologene: 32740
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: LOC268884, 5530401I02Rik, 9530025L16Rik, 4632417D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77446
Homologene: 35276
Mpo
Name: myeloperoxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17523
HGNC: HGNC:7218
Homologene: 55450
Lipg
Name: lipase, endothelial
Synonyms: mEDL, 3110013K01Rik, endothelial lipase, EL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16891
VEGA: 18
HGNC: HGNC:6623
Homologene: 21218
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228846
Homologene: 18598
Edn1
Name: endothelin 1
Synonyms: ET-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13614
VEGA: 13
HGNC: HGNC:3176
Homologene: 1476
Aox4
Name: aldehyde oxidase 4
Synonyms: AOH2, 2310003G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71872
Homologene: 70273
Cdh20
Name: cadherin 20
Synonyms: Cdh7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23836
HGNC: HGNC:1760
Homologene: 8015
Lgmn
Name: legumain
Synonyms: preprolegumain, Prsc1, AEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19141
HGNC: HGNC:9472
Homologene: 38075
Myoz3
Name: myozenin 3
Synonyms: calsarcin-3, Fatz-3, 4833419K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 170947
Homologene: 15782
Tmem38b
Name: transmembrane protein 38B
Synonyms: 1600017F22Rik, D4Ertd89e, TRIC-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52076
Homologene: 10010
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219140
Homologene: 19482
4933430I17Rik
Name: RIKEN cDNA 4933430I17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214106
Homologene: 51897
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: Rank, TRANCE-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21934
Homologene: 2848
Or5ae1
Name: olfactory receptor family 5 subfamily AE member 1
Synonyms: GA_x6K02T2NHDJ-11170115-11169168, MOR254-1, Olfr290
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258411
Homologene: 83130
Or4k41
Name: olfactory receptor family 4 subfamily K member 41
Synonyms: GA_x6K02T2Q125-72500603-72501520, MOR248-15, Olfr1287
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257935
Mks1
Name: MKS transition zone complex subunit 1
Synonyms: B8d3, avc6, Meckel syndrome, type 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380718
HGNC: HGNC:7121
Homologene: 9833
Gmeb2
Name: glucocorticoid modulatory element binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229004
HGNC: HGNC:4371
Homologene: 8228
Cdk14
Name: cyclin-dependent kinase 14
Synonyms: Pftk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18647
HGNC: HGNC:8883
Homologene: 7888
Dpysl2
Name: dihydropyrimidinase-like 2
Synonyms: Ulip2, Crmp2, TOAD-64, DRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12934
HGNC: HGNC:3014
Homologene: 74392
Tgfbr3l
Name: transforming growth factor, beta receptor III-like
Synonyms: LOC100039590, Gm14378
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100044509
Homologene: 130375
Insyn2a
Name: inhibitory synaptic factor 2A
Synonyms: B830028B13Rik, Fam196a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 627214
Homologene: 85469
1700067K01Rik
Name: RIKEN cDNA 1700067K01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73453
Homologene: 85176
Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Synonyms: mHS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15360
HGNC: HGNC:5008
Homologene: 38066
C1s2
Name: complement component 1, s subcomponent 2
Synonyms: Gm5077
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 317677
HGNC: HGNC:1247
Homologene: 1314
Mllt11
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11
Synonyms: Af1q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56772
Homologene: 4964
Klra14-ps
Name: killer cell lectin-like receptor subfamily A, member 14, pseudogene
Synonyms: Ly49N, EG654449, Gm15858, Klra14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 654449
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 58,245,873 bp
  • T to C, chromosome 1 at 104,984,910 bp
  • T to A, chromosome 1 at 105,813,820 bp
  • A to T, chromosome 2 at 28,665,185 bp
  • A to G, chromosome 2 at 111,450,009 bp
  • A to G, chromosome 2 at 158,220,392 bp
  • A to T, chromosome 2 at 181,264,989 bp
  • T to A, chromosome 3 at 28,611,971 bp
  • A to G, chromosome 3 at 95,220,204 bp
  • T to A, chromosome 3 at 98,291,162 bp
  • A to G, chromosome 3 at 114,097,094 bp
  • G to C, chromosome 4 at 53,849,051 bp
  • T to C, chromosome 4 at 62,525,869 bp
  • A to C, chromosome 5 at 5,266,036 bp
  • A to G, chromosome 5 at 34,966,352 bp
  • A to T, chromosome 5 at 98,737,707 bp
  • T to C, chromosome 6 at 87,377,436 bp
  • A to T, chromosome 6 at 124,625,743 bp
  • A to G, chromosome 6 at 130,157,788 bp
  • A to T, chromosome 7 at 12,774,456 bp
  • G to T, chromosome 7 at 25,334,597 bp
  • A to G, chromosome 7 at 43,225,887 bp
  • C to T, chromosome 7 at 46,099,818 bp
  • A to G, chromosome 7 at 80,397,855 bp
  • A to G, chromosome 7 at 84,916,183 bp
  • G to A, chromosome 7 at 105,772,809 bp
  • C to A, chromosome 7 at 134,918,796 bp
  • A to G, chromosome 8 at 4,250,360 bp
  • T to C, chromosome 8 at 69,226,461 bp
  • A to G, chromosome 8 at 84,002,998 bp
  • A to T, chromosome 9 at 42,338,926 bp
  • T to C, chromosome 9 at 110,548,823 bp
  • C to T, chromosome 10 at 10,391,757 bp
  • A to T, chromosome 11 at 87,801,755 bp
  • A to G, chromosome 11 at 87,856,839 bp
  • A to G, chromosome 11 at 106,020,256 bp
  • T to A, chromosome 12 at 3,500,603 bp
  • T to A, chromosome 12 at 16,673,842 bp
  • A to T, chromosome 12 at 102,404,328 bp
  • A to T, chromosome 13 at 42,303,667 bp
  • T to C, chromosome 14 at 16,548,545 bp
  • A to T, chromosome 14 at 50,485,995 bp
  • T to G, chromosome 14 at 60,692,003 bp
  • A to G, chromosome 14 at 66,813,146 bp
  • A to G, chromosome 15 at 5,015,401 bp
  • A to T, chromosome 16 at 32,754,769 bp
  • A to G, chromosome 16 at 33,742,404 bp
  • T to A, chromosome 16 at 37,061,018 bp
  • T to C, chromosome 17 at 80,539,522 bp
  • T to C, chromosome 18 at 35,341,117 bp
  • T to A, chromosome 18 at 52,488,946 bp
  • T to C, chromosome 18 at 60,579,032 bp
  • C to T, chromosome 18 at 74,955,434 bp
  • T to A, chromosome 19 at 44,523,144 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5708 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043333-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.