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Strain Name:
C57BL/6J-MtgxR5728Btlr
Stock Number:
043345-MU
Citation ID:
RRID:MMRRC_043345-MU
Other Names:
R5728 (G1)
Major Collection:

Strain Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFAT1, NFATp, NFAT1-D
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Elp2
Name: elongator acetyltransferase complex subunit 2
Synonyms: Stat3-interacting protein, StIP1, Statip1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58523
VEGA: 18
Homologene: 6019
Exoc6b
Name: exocyst complex component 6B
Synonyms: 4930569O18Rik, G430127E12Rik, Sec15b, Sec15l2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75914
Homologene: 44781
Foxj3
Name: forkhead box J3
Synonyms: C330039G02Rik, Fhd6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230700
Homologene: 35243
Stx16
Name: syntaxin 16
Synonyms: 5430410K23Rik, SYN16, 6330500A18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228960
Homologene: 2791
Fasn
Name: fatty acid synthase
Synonyms: FAS, A630082H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52357
Homologene: 32618
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Slc10a4
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231290
Homologene: 15495
Cnih1
Name: cornichon family AMPA receptor auxiliary protein 1
Synonyms: Cnih
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12793
Homologene: 4219
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Dhps
Name: deoxyhypusine synthase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330817
HGNC: HGNC:2869
Homologene: 1453
Wnt8b
Name: wingless-type MMTV integration site family, member 8B
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22423
VEGA: 19
Homologene: 2550
Moxd1
Name: monooxygenase, DBH-like 1
Synonyms: 3230402N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59012
Homologene: 22904
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Zfp354a
Name: zinc finger protein 354A
Synonyms: kid1, Tcf17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21408
Homologene: 55921
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: Ae3, A930038D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20536
Homologene: 129474
Igkv6-29
Name: immunoglobulin kappa chain variable 6-29
Synonyms: Gm16692
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 620191
HGNC: HGNC:5834
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75777
Homologene: 44907
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Dist1, Egfr-rs, Dist
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13650
Homologene: 32085
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Wrap73
Name: WD repeat containing, antisense to Trp73
Synonyms: DD57, 2610044M17Rik, 5330425N03Rik, Wdr8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 59002
Homologene: 9857
Map9
Name: microtubule-associated protein 9
Synonyms: 5033421J10Rik, 5330427D05Rik, ASAP, Mtap9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213582
Homologene: 41591
Vmn1r56
Name: vomeronasal 1 receptor 56
Synonyms: V3R3, V1rd3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81015
Homologene: 41799
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Or52n2
Name: olfactory receptor family 52 subfamily N member 2
Synonyms: GA_x6K02T2PBJ9-7522449-7521493, MOR34-1, Olfr666
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259100
Homologene: 64956
A930018P22Rik
Name: RIKEN cDNA A930018P22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68243
Homologene: 41690
Gpbar1
Name: G protein-coupled bile acid receptor 1
Synonyms: GPR131, M-BAR, BG37, TGR5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227289
Homologene: 18125
B4galnt4
Name: beta-1,4-N-acetyl-galactosaminyl transferase 4
Synonyms: LOC381951
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330671
Homologene: 27982
Toporsl
Name: topoisomerase I binding, arginine/serine-rich like
Synonyms: 4930547C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68274
Homologene: 130753
Cybb
Name: cytochrome b-245, beta polypeptide
Synonyms: gp91phox, gp91phox, Nox2, Cgd
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 13058
HGNC: HGNC:2578
Homologene: 68054
Mzf1
Name: myeloid zinc finger 1
Synonyms: Znf42, Mzf2, Zfp121, Zfp98
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109889
Homologene: 9633
Dcun1d4
Name: defective in cullin neddylation 1 domain containing 4
Synonyms: DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100737
Homologene: 22867
Ubap1l
Name: ubiquitin-associated protein 1-like
Synonyms: LOC208080, Gm514
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208080
VEGA: 9
Homologene: 19477
Tagap1
Name: T cell activation GTPase activating protein 1
Synonyms: 2610315E15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 380608
VEGA: 17
Lysmd3
Name: LysM, putative peptidoglycan-binding, domain containing 3
Synonyms: 1110030H10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 80289
VEGA: 13
Homologene: 12722
Chtop
Name: chromatin target of PRMT1
Synonyms: friend of Prmt1, Fop, 2500003M10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66511
Homologene: 137362
Mfsd4b2
Name: major facilitator superfamily domain containing 4B2
Synonyms: 2010001E11Rik, Mfsd4b2-ps, Mfsd4b2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72045
Homologene: 129931
Prss2
Name: serine protease 2
Synonyms: TRYP, Ta, Tesp4, TRY8, Try2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22072
HGNC: HGNC:9483
Homologene: 122141
Lurap1
Name: leucine rich adaptor protein 1
Synonyms: 1520402A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68075
Homologene: 66379
Sqrdl
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,279,057 bp
  • A to G, chromosome 1 at 75,549,840 bp
  • A to G, chromosome 2 at 91,945,787 bp
  • T to A, chromosome 2 at 104,122,868 bp
  • A to G, chromosome 2 at 122,809,400 bp
  • A to G, chromosome 2 at 168,480,249 bp
  • G to A, chromosome 2 at 174,093,499 bp
  • G to A, chromosome 3 at 82,363,335 bp
  • C to T, chromosome 3 at 90,500,092 bp
  • A to G, chromosome 3 at 92,719,345 bp
  • T to C, chromosome 4 at 52,611,469 bp
  • T to C, chromosome 4 at 116,144,388 bp
  • A to T, chromosome 4 at 119,573,762 bp
  • T to C, chromosome 4 at 137,542,766 bp
  • T to C, chromosome 4 at 154,154,642 bp
  • A to T, chromosome 5 at 73,012,334 bp
  • T to C, chromosome 5 at 73,520,148 bp
  • T to C, chromosome 6 at 41,523,917 bp
  • C to A, chromosome 6 at 70,138,600 bp
  • T to C, chromosome 6 at 84,860,191 bp
  • A to T, chromosome 7 at 5,196,123 bp
  • A to G, chromosome 7 at 13,044,058 bp
  • C to T, chromosome 7 at 104,893,229 bp
  • A to G, chromosome 7 at 141,070,575 bp
  • A to G, chromosome 8 at 23,122,767 bp
  • A to G, chromosome 8 at 47,864,061 bp
  • A to G, chromosome 8 at 85,073,335 bp
  • T to C, chromosome 9 at 65,369,288 bp
  • A to T, chromosome 9 at 73,558,956 bp
  • A to T, chromosome 10 at 24,223,683 bp
  • A to C, chromosome 10 at 39,923,795 bp
  • T to A, chromosome 11 at 9,570,576 bp
  • A to G, chromosome 11 at 32,209,901 bp
  • T to C, chromosome 11 at 48,888,613 bp
  • T to A, chromosome 11 at 51,070,605 bp
  • A to T, chromosome 11 at 60,488,896 bp
  • A to C, chromosome 11 at 120,813,513 bp
  • A to G, chromosome 13 at 81,669,261 bp
  • A to G, chromosome 14 at 46,780,191 bp
  • G to T, chromosome 15 at 10,551,550 bp
  • A to G, chromosome 15 at 91,774,974 bp
  • A to G, chromosome 17 at 3,414,956 bp
  • A to G, chromosome 17 at 6,957,021 bp
  • A to G, chromosome 18 at 24,617,452 bp
  • A to G, chromosome 19 at 44,511,318 bp
  • C to G, chromosome X at 9,450,750 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5728 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043345-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.