Strain Name:
C57BL/6J-MtgxR5735Btlr/Mmmh
Stock Number:
043349-MU
Citation ID:
RRID:MMRRC_043349-MU
Other Names:
R5735 (G1)
Major Collection:

Gene Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Psen2
Name: presenilin 2
Synonyms: ALG-3, PS-2, PS2, Ad4h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19165
HGNC: HGNC:9509
Homologene: 386
Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20269
Homologene: 56005
Pomt1
Name: protein-O-mannosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99011
HGNC: HGNC:9202
Homologene: 68548
Cacng7
Name: calcium channel, voltage-dependent, gamma subunit 7
Synonyms: TARP gamma 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81904
Homologene: 12895
Zfp809
Name: zinc finger protein 809
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235047
VEGA: 9
Prdm5
Name: PR domain containing 5
Synonyms: 6530401I24Rik, E130112L17Rik, PFM2, 4432417F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70779
HGNC: HGNC:9349
Homologene: 10274
Bnc2
Name: basonuclin 2
Synonyms: 5031434M05Rik, 8430420F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242509
Homologene: 18243
Armc8
Name: armadillo repeat containing 8
Synonyms: HSPC056, 1200015K23Rik, Gid5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74125
Homologene: 9121
Ubxn4
Name: UBX domain protein 4
Synonyms: 1300013G12Rik, Ubxd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67812
Homologene: 40962
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Phka2
Name: phosphorylase kinase alpha 2
Synonyms: k, Phk, 6330505C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 110094
HGNC: HGNC:8926
Homologene: 246
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: Cip2a, C330027C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224171
Homologene: 10842
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
Trim2
Name: tripartite motif-containing 2
Synonyms: neural activity-related ring finger protein, narf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80890
Homologene: 22882
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2610107G07Rik, 1110033L15Rik, 2900006F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72899
Homologene: 85987
Themis
Name: thymocyte selection associated
Synonyms: E430004N04Rik, Gasp, Tsepa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210757
Homologene: 72287
Cmtm2a
Name: CKLF-like MARVEL transmembrane domain containing 2A
Synonyms: 1700001K04Rik, 1700041N15Rik, 1700063K20Rik, Cklf, ARR19, Cklfsf2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73381
Homologene: 88508
Itih5
Name: inter-alpha (globulin) inhibitor H5
Synonyms: 5430408M01Rik, 4631408O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209378
Homologene: 57115
Mfsd2a
Name: major facilitator superfamily domain containing 2A
Synonyms: 1700018O18Rik, Mfsd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76574
Homologene: 19229
Zfta
Name: zinc finger translocation associated
Synonyms: 2700081O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 108899
Homologene: 52179
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, LOC380767, A630028O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Eps8l2
Name: EPS8-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 98845
Homologene: 69358
Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Synonyms: PC-1, NPP1, Npps, Pca-1, Pca, Ly-41, Pdnp1, twy, CD203c, E-NPP1, 4833416E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18605
HGNC: HGNC:3356
Homologene: 38151
Rtn3
Name: reticulon 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20168
VEGA: 19
Homologene: 24934
Skor1
Name: SKI family transcriptional corepressor 1
Synonyms: Corl1, C230094B15Rik, Lbxcor1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 207667
Homologene: 18175
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTP-BL, Ptpri, PTPL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Pde10a
Name: phosphodiesterase 10A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 23984
HGNC: HGNC:8772
Homologene: 4852
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Trgv5
Name: T cell receptor gamma, variable 5
Synonyms: Tcrg-V5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 21639
Kcna10
Name: potassium voltage-gated channel, shaker-related subfamily, member 10
Synonyms: Kv1.8, Kcna8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242151
HGNC: HGNC:6219
Homologene: 4054
Npas3
Name: neuronal PAS domain protein 3
Synonyms: 4930423H22Rik, bHLHe12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Vwce
Name: von Willebrand factor C and EGF domains
Synonyms: 1300015B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71768
VEGA: 19
Homologene: 17651
Kif6
Name: kinesin family member 6
Synonyms: D130004B10Rik, D130084M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 319991
Homologene: 35308
Adamts16
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 271127
Homologene: 15146
Atg4b
Name: autophagy related 4B, cysteine peptidase
Synonyms: Apg4b, 2510009N07Rik, autophagin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66615
Homologene: 100868
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 5930426O13Rik, 9030605H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319767
Homologene: 70969
Tbc1d2b
Name: TBC1 domain family, member 2B
Synonyms: 1810061M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67016
Homologene: 56694
Ptprt
Name: protein tyrosine phosphatase, receptor type, T
Synonyms: RPTPrho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66898
Homologene: 23123
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030018G17Rik, 1110018I21Rik, Tns, E030037J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21961
Homologene: 11219
Olfr1100
Name: olfactory receptor 1100
Synonyms: GA_x6K02T2Q125-48465387-48464422, MOR206-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258587
Homologene: 34954
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665227
Homologene: 129751
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Pramel22
Name: PRAME like 22
Synonyms: Gm13088
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277668
Homologene: 129883
Galnt1
Name: polypeptide N-acetylgalactosaminyltransferase 1
Synonyms: ppGaNTase-T1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14423
HGNC: HGNC:4123
Homologene: 8469
Fam234a
Name: family with sequence similarity 234, member A
Synonyms: Itfg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106581
Homologene: 12932
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Ifnl2
Name: interferon lambda 2
Synonyms: EG330496, Il28a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330496
Homologene: 77540
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384221
Homologene: 104825
Lpar2
Name: lysophosphatidic acid receptor 2
Synonyms: LPA2, Edg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 53978
VEGA: 8
HGNC: HGNC:3168
Homologene: 3465
Olfr669
Name: olfactory receptor 669
Synonyms: GA_x6K02T2PBJ9-7567376-7568329, MOR34-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259045
Homologene: 72057
Potea
Name: POTE ankyrin domain family member A
Synonyms: 4930430A15Rik, A26c3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67575
Homologene: 69410
Sgms2
Name: sphingomyelin synthase 2
Synonyms: 4933405A16Rik, 5133401H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74442
Homologene: 32705
Erlec1
Name: endoplasmic reticulum lectin 1
Synonyms: 4933407N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66753
Homologene: 9247
Olfr1107
Name: olfactory receptor 1107
Synonyms: GA_x6K02T2Q125-48565383-48564445, MOR172-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258841
Homologene: 131138
Zfp995
Name: zinc finger protein 995
Synonyms: 2210404O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70081
Homologene: 133253
9130019O22Rik
Name: RIKEN cDNA 9130019O22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78921
Homologene: 118005
Tmem203
Name: transmembrane protein 203
Synonyms: C730025P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227615
Homologene: 107047
Zfp397
Name: zinc finger protein 397
Synonyms: 2810411K16Rik, 6720480F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69256
VEGA: 18
Homologene: 117445
Olfr1242
Name: olfactory receptor 1242
Synonyms: GA_x6K02T2Q125-50937307-50936387, MOR231-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258970
Homologene: 27316
Cfap73
Name: cilia and flagella associated protein 73
Synonyms: Gm5988, Ccdc42b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 546886
Homologene: 53205
Rltpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
0610007P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 73,927,979 bp
  • G to T, chromosome 1 at 93,773,797 bp
  • T to C, chromosome 1 at 128,258,940 bp
  • T to A, chromosome 1 at 180,240,926 bp
  • T to C, chromosome 1 at 189,654,363 bp
  • A to G, chromosome 2 at 10,240,761 bp
  • T to C, chromosome 2 at 25,256,073 bp
  • G to A, chromosome 2 at 32,243,505 bp
  • A to T, chromosome 2 at 65,482,278 bp
  • T to A, chromosome 2 at 65,484,459 bp
  • A to G, chromosome 2 at 86,978,700 bp
  • A to T, chromosome 2 at 87,071,412 bp
  • A to T, chromosome 2 at 89,493,468 bp
  • A to T, chromosome 2 at 111,225,492 bp
  • A to G, chromosome 2 at 140,418,889 bp
  • A to G, chromosome 2 at 161,534,564 bp
  • C to T, chromosome 3 at 38,949,576 bp
  • G to A, chromosome 3 at 84,167,722 bp
  • A to G, chromosome 3 at 107,195,078 bp
  • A to T, chromosome 3 at 131,336,217 bp
  • A to C, chromosome 4 at 84,292,671 bp
  • A to T, chromosome 4 at 122,949,327 bp
  • G to T, chromosome 4 at 131,838,090 bp
  • A to T, chromosome 4 at 143,654,635 bp
  • T to G, chromosome 5 at 48,259,616 bp
  • C to A, chromosome 5 at 103,554,820 bp
  • A to G, chromosome 5 at 109,452,850 bp
  • T to A, chromosome 5 at 120,632,606 bp
  • A to G, chromosome 5 at 144,286,302 bp
  • A to G, chromosome 5 at 150,991,538 bp
  • C to T, chromosome 6 at 65,927,990 bp
  • T to C, chromosome 7 at 3,339,023 bp
  • T to A, chromosome 7 at 28,510,189 bp
  • A to T, chromosome 7 at 104,938,759 bp
  • G to T, chromosome 7 at 127,385,407 bp
  • A to G, chromosome 7 at 141,360,377 bp
  • G to T, chromosome 8 at 69,823,735 bp
  • A to T, chromosome 8 at 104,292,786 bp
  • G to A, chromosome 8 at 105,698,031 bp
  • T to A, chromosome 9 at 22,238,931 bp
  • T to A, chromosome 9 at 63,146,064 bp
  • T to A, chromosome 9 at 90,222,409 bp
  • T to A, chromosome 9 at 99,497,394 bp
  • A to T, chromosome 10 at 24,654,919 bp
  • A to G, chromosome 10 at 28,722,534 bp
  • T to A, chromosome 10 at 76,599,893 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • A to T, chromosome 11 at 30,950,591 bp
  • A to T, chromosome 11 at 43,151,774 bp
  • A to G, chromosome 11 at 69,430,817 bp
  • A to T, chromosome 12 at 54,003,479 bp
  • T to C, chromosome 12 at 79,273,373 bp
  • C to T, chromosome 12 at 85,816,152 bp
  • T to G, chromosome 13 at 19,192,525 bp
  • C to A, chromosome 13 at 70,836,218 bp
  • T to A, chromosome 16 at 49,017,493 bp
  • A to T, chromosome 17 at 8,941,192 bp
  • G to T, chromosome 17 at 18,243,804 bp
  • C to T, chromosome 17 at 21,882,029 bp
  • T to C, chromosome 17 at 26,213,705 bp
  • G to A, chromosome 17 at 49,832,182 bp
  • T to C, chromosome 18 at 23,960,192 bp
  • T to G, chromosome 18 at 24,264,520 bp
  • T to C, chromosome 18 at 67,880,795 bp
  • A to G, chromosome 19 at 7,422,796 bp
  • T to C, chromosome 19 at 7,456,692 bp
  • C to A, chromosome 19 at 10,647,067 bp
  • ACC to AC, chromosome X at 160,559,866 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5735 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043349-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.