Strain Name:
C57BL/6J-MtgxR5743Btlr
Stock Number:
043353-MU
Citation ID:
RRID:MMRRC_043353-MU
Other Names:
R5743 (G1)
Major Collection:

Strain Information

Pcdh9
Name: protocadherin 9
Synonyms: 1500001L12Rik, C530050I23Rik, C630029H24Rik, A730003J17Rik, LOC382930
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Smug1
Name: single-strand selective monofunctional uracil DNA glycosylase
Synonyms: 1200013B09Rik, A930006H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71726
VEGA: 15
Homologene: 8629
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: 9030624J02Rik, Vsp35l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71517
Homologene: 10659
Plxna1
Name: plexin A1
Synonyms: 2600013D04Rik, Plxn1, NOV, PlexA1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Zc3h3
Name: zinc finger CCCH type containing 3
Synonyms: Smicl
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223642
VEGA: 15
Homologene: 9029
Orc6
Name: origin recognition complex, subunit 6
Synonyms: 6720420I10Rik, Orc6l
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56452
Homologene: 8635
Cstf1
Name: cleavage stimulation factor, 3' pre-RNA, subunit 1
Synonyms: 1700057K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67337
HGNC: HGNC:2483
Homologene: 1012
Qrich1
Name: glutamine-rich 1
Synonyms: 2610028H07Rik, b2b2404Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69232
Homologene: 9803
Mcpt1
Name: mast cell protease 1
Synonyms: Mcp-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17224
VEGA: 14
Homologene: 137209
Coq5
Name: coenzyme Q5 methyltransferase
Synonyms: 1810014G04Rik, D5Ertd33e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52064
Homologene: 6559
Zfp369
Name: zinc finger protein 369
Synonyms: B930030B22Rik, NRIF2, D230020H11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 170936
Homologene: 129707
Il31ra
Name: interleukin 31 receptor A
Synonyms: GPL, GLM-R
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218624
VEGA: 13
Homologene: 51395
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Fbxo46
Name: F-box protein 46
Synonyms: 20D7-FC4, 4932704E22Rik, Fbxo34l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243867
Homologene: 18467
Tmem130
Name: transmembrane protein 130
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243339
Homologene: 17680
Baiap3
Name: BAI1-associated protein 3
Synonyms: LOC381076
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 545192
HGNC: HGNC:948
Homologene: 20844
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Dchs1
Name: dachsous cadherin related 1
Synonyms: 3110041P15Rik, C130033F22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Arhgap20
Name: Rho GTPase activating protein 20
Synonyms: A530023E23Rik, 6530403F17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244867
Homologene: 18938
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: D430029O09Rik, Polydom, 1110021D17Rik, 4833413O10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Ush2a
Name: usherin
Synonyms: MUSH2A, A930037M10Rik, LOC381317, LOC269160, Ushrn, A930011D15Rik, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Glce
Name: glucuronyl C5-epimerase
Synonyms: heparan sulfate-glucuronic acid C5-epimerase, 1110017N23Rik, C130034A12Rik, Hsepi
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93683
Homologene: 14111
Igkv6-29
Name: immunoglobulin kappa chain variable 6-29
Synonyms: Gm16692
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 620191
HGNC: HGNC:5834
Ccl1
Name: C-C motif chemokine ligand 1
Synonyms: CCR8 ligand, Tca-3, I-309, Scya1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20290
Homologene: 55541
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: C76601, Parg1, B130017I01Rik, 6720461J18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214137
Homologene: 3539
Cdh7
Name: cadherin 7, type 2
Synonyms: 9330156F07Rik, CDH7L1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Or8c13
Name: olfactory receptor family 8 subfamily C member 13
Synonyms: MOR170-9, Olfr891, GA_x6K02T2PVTD-31862167-31861217
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258471
Homologene: 74210
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Gm16432
Name: predicted gene 16432
Type: Gene
Species: Mouse
Chromosome: 1
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Sema5b
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Synonyms: SemG, Semag, SemG
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20357
Homologene: 8427
Rgs1
Name: regulator of G-protein signaling 1
Synonyms: BL34
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 50778
HGNC: HGNC:9991
Homologene: 2191
Or8h8
Name: olfactory receptor family 8 subfamily H member 8
Synonyms: MOR206-1, GA_x6K02T2Q125-48410458-48409511, Olfr1098
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258842
Homologene: 37005
Caskin2
Name: CASK-interacting protein 2
Synonyms: 1600028L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140721
Homologene: 32485
Nrxn1
Name: neurexin I
Synonyms: neurexin I beta, neurexin I alpha, neurexin I alpha, neurexin I beta, 1700062G21Rik, alpha-latrotoxin receptor (calcium-dependent), A230068P09Rik, 9330127H16Rik, neurexin I beta, neurexin I alpha
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Ctsll3
Name: cathepsin L-like 3
Synonyms: 2310051M13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70202
VEGA: 13
Homologene: 134916
Kcnk4
Name: potassium channel, subfamily K, member 4
Synonyms: TRAAKt
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16528
VEGA: 19
HGNC: HGNC:6279
Homologene: 7391
Sh2b3
Name: SH2B adaptor protein 3
Synonyms: Lnk
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16923
Homologene: 36179
Ssrp1
Name: structure specific recognition protein 1
Synonyms: Hmgox, Hmg1-rs1, Hmgi-rs3, T160
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20833
Homologene: 110735
Spata31f3
Name: spermatogenesis associated 31 subfamily F member 3
Synonyms: BC049635, Fam205c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277773
Homologene: 77625
Vezt
Name: vezatin, adherens junctions transmembrane protein
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215008
Homologene: 9739
Slc27a3
Name: solute carrier family 27 (fatty acid transporter), member 3
Synonyms: Acsvl3, fatty acid transport protein 3, FATP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26568
Homologene: 11529
Trim30d
Name: tripartite motif-containing 30D
Synonyms: Trim79, TRIM30-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209387
Homologene: 114426
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433586
Homologene: 41284
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243833
Homologene: 10889
Slc35f1
Name: solute carrier family 35, member F1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215085
Homologene: 33552
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: Acas1, Acs1, AceCS1, Acas2, ACAS, acetyl-CoA synthetase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60525
Homologene: 6469
Or52e7
Name: olfactory receptor family 52 subfamily E member 7
Synonyms: MOR32-1, Olfr676, GA_x6K02T2PBJ9-7664016-7664969
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259099
Homologene: 64955
Ankef1
Name: ankyrin repeat and EF-hand domain containing 1
Synonyms: Ankrd5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319196
Homologene: 11130
Ccdc159
Name: coiled-coil domain containing 159
Synonyms: 2510048L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67119
VEGA: 9
Homologene: 12084
Rasl10a
Name: RAS-like, family 10, member A
Synonyms: 2210403B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75668
Homologene: 4732
Prop1
Name: paired like homeodomain factor 1
Synonyms: prophet of Pit-1, prophet of Pit1, Prop-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19127
HGNC: HGNC:9455
Homologene: 4558
Pcdhga9
Name: protocadherin gamma subfamily A, 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93717
HGNC: HGNC:8707
Homologene: 56827
Cga
Name: glycoprotein hormones, alpha subunit
Synonyms: aGSU, alphaSU, alphaGSU, Tsha, alpha-GSU, GPHalpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12640
HGNC: HGNC:1885
Homologene: 587
Gm20830
Name: predicted gene, 20830
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 108168638
Krtap10-33
Name: keratin associated protein 10-33
Synonyms: Gm19402
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100502831
VEGA: 10
Homologene: 115744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 110,108,845 bp
  • T to C, chromosome 1 at 144,245,372 bp
  • G to T, chromosome 1 at 178,122,762 bp
  • A to G, chromosome 1 at 188,436,962 bp
  • C to A, chromosome 2 at 69,466,877 bp
  • T to A, chromosome 2 at 85,041,168 bp
  • C to A, chromosome 2 at 86,923,205 bp
  • A to G, chromosome 2 at 136,549,709 bp
  • A to G, chromosome 2 at 155,574,616 bp
  • T to A, chromosome 2 at 172,377,833 bp
  • G to T, chromosome 3 at 52,104,132 bp
  • G to T, chromosome 3 at 90,387,072 bp
  • T to A, chromosome 3 at 110,135,420 bp
  • T to G, chromosome 3 at 121,981,911 bp
  • T to C, chromosome 4 at 34,904,108 bp
  • G to A, chromosome 4 at 42,873,087 bp
  • T to C, chromosome 4 at 58,096,223 bp
  • T to C, chromosome 4 at 81,421,188 bp
  • A to C, chromosome 5 at 115,279,882 bp
  • A to T, chromosome 5 at 121,828,457 bp
  • A to G, chromosome 5 at 144,750,939 bp
  • T to C, chromosome 6 at 58,918,799 bp
  • C to A, chromosome 6 at 70,138,600 bp
  • A to T, chromosome 6 at 89,356,529 bp
  • C to T, chromosome 7 at 12,884,727 bp
  • C to A, chromosome 7 at 19,136,495 bp
  • T to G, chromosome 7 at 42,476,431 bp
  • A to T, chromosome 7 at 104,472,328 bp
  • A to G, chromosome 7 at 105,036,156 bp
  • T to A, chromosome 7 at 105,771,596 bp
  • A to G, chromosome 7 at 118,797,011 bp
  • A to T, chromosome 8 at 15,080,914 bp
  • A to T, chromosome 8 at 80,615,778 bp
  • A to T, chromosome 8 at 85,302,956 bp
  • A to T, chromosome 9 at 21,929,390 bp
  • C to A, chromosome 9 at 38,180,718 bp
  • T to A, chromosome 9 at 51,816,727 bp
  • T to A, chromosome 9 at 62,070,540 bp
  • T to A, chromosome 9 at 108,534,115 bp
  • T to G, chromosome 10 at 53,089,450 bp
  • C to T, chromosome 10 at 77,690,682 bp
  • A to T, chromosome 10 at 93,997,095 bp
  • G to A, chromosome 10 at 107,857,001 bp
  • T to A, chromosome 11 at 5,059,519 bp
  • T to C, chromosome 11 at 50,951,009 bp
  • T to G, chromosome 11 at 82,176,886 bp
  • T to A, chromosome 11 at 115,802,289 bp
  • G to T, chromosome 13 at 60,801,001 bp
  • G to T, chromosome 13 at 65,295,680 bp
  • G to T, chromosome 13 at 112,527,487 bp
  • A to G, chromosome 13 at 114,884,506 bp
  • A to T, chromosome 14 at 56,018,615 bp
  • T to C, chromosome 14 at 93,886,724 bp
  • G to T, chromosome 15 at 75,779,531 bp
  • C to A, chromosome 15 at 103,157,616 bp
  • T to A, chromosome 16 at 35,658,476 bp
  • G to A, chromosome 17 at 25,244,785 bp
  • C to A, chromosome 17 at 90,643,224 bp
  • A to T, chromosome 18 at 37,738,806 bp
  • A to T, chromosome 19 at 6,928,355 bp
  • A to G, chromosome Y at 6,916,664 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5743 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043353-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.