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Strain Name:
C57BL/6J-MtgxR5743Btlr
Stock Number:
043353-MU
Citation ID:
RRID:MMRRC_043353-MU
Other Names:
R5743 (G1)
Major Collection:

Strain Information

Pcdh9
Name: protocadherin 9
Synonyms: C630029H24Rik, 1500001L12Rik, LOC382930, A730003J17Rik, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Smug1
Name: single-strand selective monofunctional uracil DNA glycosylase
Synonyms: 1200013B09Rik, A930006H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71726
VEGA: 15
Homologene: 8629
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: 9030624J02Rik, Vsp35l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71517
Homologene: 10659
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, 2600013D04Rik, PlexA1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Zc3h3
Name: zinc finger CCCH type containing 3
Synonyms: Smicl
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223642
VEGA: 15
Homologene: 9029
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 110,108,845 bp
  • T to C, chromosome 1 at 144,245,372 bp
  • G to T, chromosome 1 at 178,122,762 bp
  • A to G, chromosome 1 at 188,436,962 bp
  • C to A, chromosome 2 at 69,466,877 bp
  • T to A, chromosome 2 at 85,041,168 bp
  • C to A, chromosome 2 at 86,923,205 bp
  • A to G, chromosome 2 at 136,549,709 bp
  • A to G, chromosome 2 at 155,574,616 bp
  • T to A, chromosome 2 at 172,377,833 bp
  • G to T, chromosome 3 at 52,104,132 bp
  • G to T, chromosome 3 at 90,387,072 bp
  • T to A, chromosome 3 at 110,135,420 bp
  • T to G, chromosome 3 at 121,981,911 bp
  • T to C, chromosome 4 at 34,904,108 bp
  • G to A, chromosome 4 at 42,873,087 bp
  • T to C, chromosome 4 at 58,096,223 bp
  • T to C, chromosome 4 at 81,421,188 bp
  • A to C, chromosome 5 at 115,279,882 bp
  • A to T, chromosome 5 at 121,828,457 bp
  • A to G, chromosome 5 at 144,750,939 bp
  • T to C, chromosome 6 at 58,918,799 bp
  • C to A, chromosome 6 at 70,138,600 bp
  • A to T, chromosome 6 at 89,356,529 bp
  • C to T, chromosome 7 at 12,884,727 bp
  • C to A, chromosome 7 at 19,136,495 bp
  • T to G, chromosome 7 at 42,476,431 bp
  • A to T, chromosome 7 at 104,472,328 bp
  • A to G, chromosome 7 at 105,036,156 bp
  • T to A, chromosome 7 at 105,771,596 bp
  • A to G, chromosome 7 at 118,797,011 bp
  • A to T, chromosome 8 at 15,080,914 bp
  • A to T, chromosome 8 at 80,615,778 bp
  • A to T, chromosome 8 at 85,302,956 bp
  • A to T, chromosome 9 at 21,929,390 bp
  • C to A, chromosome 9 at 38,180,718 bp
  • T to A, chromosome 9 at 51,816,727 bp
  • T to A, chromosome 9 at 62,070,540 bp
  • T to A, chromosome 9 at 108,534,115 bp
  • T to G, chromosome 10 at 53,089,450 bp
  • C to T, chromosome 10 at 77,690,682 bp
  • A to T, chromosome 10 at 93,997,095 bp
  • G to A, chromosome 10 at 107,857,001 bp
  • T to A, chromosome 11 at 5,059,519 bp
  • T to C, chromosome 11 at 50,951,009 bp
  • T to G, chromosome 11 at 82,176,886 bp
  • T to A, chromosome 11 at 115,802,289 bp
  • G to T, chromosome 13 at 60,801,001 bp
  • G to T, chromosome 13 at 65,295,680 bp
  • G to T, chromosome 13 at 112,527,487 bp
  • A to G, chromosome 13 at 114,884,506 bp
  • A to T, chromosome 14 at 56,018,615 bp
  • T to C, chromosome 14 at 93,886,724 bp
  • G to T, chromosome 15 at 75,779,531 bp
  • C to A, chromosome 15 at 103,157,616 bp
  • T to A, chromosome 16 at 35,658,476 bp
  • G to A, chromosome 17 at 25,244,785 bp
  • C to A, chromosome 17 at 90,643,224 bp
  • A to T, chromosome 18 at 37,738,806 bp
  • A to T, chromosome 19 at 6,928,355 bp
  • A to G, chromosome Y at 6,916,664 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5743 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043353-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.