Strain Name:
C57BL/6J-MtgxR5747Btlr
Stock Number:
043354-MU
Citation ID:
RRID:MMRRC_043354-MU
Other Names:
R5747 (G1)
Major Collection:

Gene Information

Epha4
Name: Eph receptor A4
Synonyms: Tyro1, rb, 2900005C20Rik, Sek, Sek1, Hek8, Cek8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: Sema6D-2, Sema6D-4, Sema6D-1, Sema6D-6, 1110067B02Rik, Sema6D-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 214968
Homologene: 16195
Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-2, Gm4392, Ank-2, ankyrin B, Ankyrin-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 109676
HGNC: HGNC:493
Mob4
Name: MOB family member 4, phocein
Synonyms: Prei3, 2610109B12Rik, Mobkl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19070
Homologene: 9116
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223666
Homologene: 27825
Slc6a4
Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms: Sert, 5-HTT, Htt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15567
Homologene: 817
Fdft1
Name: farnesyl diphosphate farnesyl transferase 1
Synonyms: Ss, SQS, squalene synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 14137
VEGA: 14
HGNC: HGNC:3629
Homologene: 3281
Rp9
Name: retinitis pigmentosa 9 (human)
Synonyms: Rp9h, PAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 55934
VEGA: 9
Homologene: 10290
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, Mcpr, Apc1, 2610021O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17222
Homologene: 7414
Cbl
Name: Casitas B-lineage lymphoma
Synonyms: c-Cbl, 4732447J05Rik, Cbl-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12402
HGNC: HGNC:1541
Homologene: 3802
Akap8l
Name: A kinase (PRKA) anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 54194
VEGA: 17
Homologene: 8658
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 30054
VEGA: 14
Homologene: 23727
Gnaz
Name: guanine nucleotide binding protein, alpha z subunit
Synonyms: Gz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14687
HGNC: HGNC:4395
Homologene: 22574
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230895
Homologene: 15583
Gbx2
Name: gastrulation brain homeobox 2
Synonyms: Stra7, Gbx-2, MMoxA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14472
HGNC: HGNC:4186
Homologene: 1138
Susd1
Name: sushi domain containing 1
Synonyms: Gm12528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 634731
Homologene: 11204
Rrm2b
Name: ribonucleotide reductase M2 B (TP53 inducible)
Synonyms: p53R2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 382985
Homologene: 56723
Kctd18
Name: potassium channel tetramerisation domain containing 18
Synonyms: 4932411A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 51960
Homologene: 12710
Spocd1
Name: SPOC domain containing 1
Synonyms: OTTMUSG00000009522
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 622480
Homologene: 83439
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Slc27a2
Name: solute carrier family 27 (fatty acid transporter), member 2
Synonyms: ACSVL1, FATP2, VLCS, FATP2, Vlacs, Vlac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26458
Homologene: 37830
Ankrd34c
Name: ankyrin repeat domain 34C
Synonyms: B230218L05Rik, LOC330998
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330998
Homologene: 19814
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Slc4a5
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms: C330016K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232156
Homologene: 31125
Wdr31
Name: WD repeat domain 31
Synonyms: 5430402I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 71354
Homologene: 11360
Olfr344
Name: olfactory receptor 344
Synonyms: GA_x6K02T2NLDC-33262744-33263673, MOR136-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258621
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: 2810043H12Rik, mSNM1, SMN1a, SNM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 55947
Homologene: 8920
Gtf2h4
Name: general transcription factor II H, polypeptide 4
Synonyms: p52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14885
HGNC: HGNC:4658
Homologene: 7090
Lman2l
Name: lectin, mannose-binding 2-like
Synonyms: VIP36-like, A630028F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 214895
Homologene: 57125
Itgbl1
Name: integrin, beta-like 1
Synonyms: B930011D01Rik, with EGF-like repeat domains
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 223272
HGNC: HGNC:6164
Homologene: 3519
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74762
Homologene: 17780
Rassf8
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Synonyms: mHoj-1, 5133400D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71323
Homologene: 5219
Dzip1l
Name: DAZ interacting protein 1-like
Synonyms: 2610524A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 72507
Homologene: 12466
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219140
Homologene: 19482
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: C130030K03Rik, Glurbeta2, Glur6, Glur-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 433171
VEGA: 18
Lrrc63
Name: leucine rich repeat containing 63
Synonyms: 4921509B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 70859
Homologene: 52823
Map3k3
Name: mitogen-activated protein kinase kinase kinase 3
Synonyms: Mekk3, MAPKKK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 26406
HGNC: HGNC:6855
Homologene: 69110
Ldhd
Name: lactate dehydrogenase D
Synonyms: 4733401P21Rik, D8Bwg1320e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 52815
Homologene: 5536
Gm5093
Name: predicted gene 5093
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 328825
VEGA: 17
Zfp783
Name: zinc finger protein 783
Synonyms: Gm20494, ENSMUSG00000072653, A230106D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232785
Gkn1
Name: gastrokine 1
Synonyms: AMP-18, BRICD1, 2200002K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 66283
Homologene: 10487
Crebl2
Name: cAMP responsive element binding protein-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232430
HGNC: HGNC:2350
Homologene: 1003
Gm527
Name: predicted gene 527
Synonyms: LOC217648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217648
VEGA: 12
Homologene: 19024
Echs1
Name: enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 93747
HGNC: HGNC:3151
Homologene: 3018
Gm6803
Name: predicted gene 6803
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
Igkv8-28
Name: immunoglobulin kappa variable 8-28
Synonyms: ENSMUSG00000073023
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 434040
Ldhal6b
Name: lactate dehydrogenase A-like 6B
Synonyms: 4933402O15Rik, LDHAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106557
Homologene: 69533
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 25,826,562 bp
  • T to C, chromosome 1 at 36,424,957 bp
  • A to G, chromosome 1 at 55,148,578 bp
  • A to T, chromosome 1 at 57,962,024 bp
  • A to G, chromosome 1 at 77,506,883 bp
  • A to G, chromosome 1 at 89,928,715 bp
  • A to T, chromosome 2 at 36,568,967 bp
  • G to C, chromosome 2 at 98,664,007 bp
  • C to T, chromosome 2 at 124,664,947 bp
  • T to A, chromosome 2 at 126,564,738 bp
  • A to G, chromosome 2 at 128,624,916 bp
  • A to G, chromosome 3 at 126,941,751 bp
  • T to A, chromosome 4 at 59,424,108 bp
  • C to T, chromosome 4 at 62,463,400 bp
  • A to G, chromosome 4 at 129,954,945 bp
  • G to A, chromosome 4 at 145,168,283 bp
  • T to C, chromosome 6 at 47,948,895 bp
  • T to C, chromosome 6 at 70,144,157 bp
  • T to A, chromosome 6 at 83,271,029 bp
  • T to A, chromosome 6 at 87,346,337 bp
  • C to T, chromosome 6 at 134,851,140 bp
  • A to G, chromosome 6 at 145,815,815 bp
  • T to C, chromosome 7 at 140,111,812 bp
  • T to C, chromosome 8 at 111,629,071 bp
  • A to G, chromosome 9 at 22,448,664 bp
  • A to G, chromosome 9 at 44,201,119 bp
  • C to T, chromosome 9 at 89,729,761 bp
  • T to A, chromosome 9 at 99,639,809 bp
  • T to C, chromosome 10 at 49,523,774 bp
  • C to T, chromosome 10 at 74,991,403 bp
  • A to T, chromosome 11 at 77,010,511 bp
  • A to G, chromosome 11 at 106,150,410 bp
  • A to T, chromosome 12 at 64,920,846 bp
  • T to C, chromosome 12 at 74,898,420 bp
  • C to T, chromosome 12 at 88,018,596 bp
  • T to C, chromosome 14 at 56,465,819 bp
  • T to A, chromosome 14 at 60,747,503 bp
  • A to G, chromosome 14 at 63,146,839 bp
  • T to C, chromosome 14 at 75,126,464 bp
  • T to A, chromosome 14 at 123,972,164 bp
  • T to C, chromosome 15 at 37,927,390 bp
  • C to T, chromosome 15 at 76,741,535 bp
  • A to C, chromosome 17 at 5,417,819 bp
  • C to T, chromosome 17 at 29,850,551 bp
  • T to C, chromosome 17 at 32,345,378 bp
  • T to C, chromosome 17 at 35,670,381 bp
  • T to G, chromosome 17 at 46,439,990 bp
  • C to A, chromosome 18 at 33,464,305 bp
  • A to G, chromosome 19 at 56,541,532 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5747 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043354-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.