Strain Name:
C57BL/6J-MtgxR5750Btlr
Stock Number:
043356-MU
Citation ID:
RRID:MMRRC_043356-MU
Other Names:
R5750 (G1)
Major Collection:

Gene Information

Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: Tkrb, C030027L06Rik, trkB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: Mtssk, MAST205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17776
Homologene: 7428
Ints8
Name: integrator complex subunit 8
Synonyms: D130008D20Rik, 2810013E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72656
Homologene: 9888
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, C130039F11Rik, nesprin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 64009
VEGA: 10
Homologene: 52329
Tmem126b
Name: transmembrane protein 126B
Synonyms: 1110001A23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68472
Homologene: 10222
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105203
VEGA: 13
Homologene: 26435
Xpo5
Name: exportin 5
Synonyms: 2410004H11Rik, Exp5, 2700038C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 72322
VEGA: 17
Homologene: 69316
Unc45a
Name: unc-45 myosin chaperone A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101869
Homologene: 32423
Slc22a3
Name: solute carrier family 22 (organic cation transporter), member 3
Synonyms: Orct3, Oct3, EMT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20519
VEGA: 17
Homologene: 22630
Macrod2
Name: MACRO domain containing 2
Synonyms: 2900006F19Rik, 1110033L15Rik, 2610107G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 72899
Homologene: 85987
Leng8
Name: leukocyte receptor cluster (LRC) member 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 232798
Homologene: 13612
Creb3l1
Name: cAMP responsive element binding protein 3-like 1
Synonyms: Oasis, BBF-2 (drosophila) homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26427
Homologene: 8058
Agr3
Name: anterior gradient 3
Synonyms: E030025L21Rik, LOC380754
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 403205
Homologene: 45551
Gna15
Name: guanine nucleotide binding protein, alpha 15
Synonyms: G[a]15, Galpha15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14676
HGNC: HGNC:4383
Homologene: 1563
Hk1
Name: hexokinase 1
Synonyms: Hk1-s, Hk-1, mHk1-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Rps5
Name: ribosomal protein S5
Synonyms: S5 ribosomal protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20103
Homologene: 783
P3h1
Name: prolyl 3-hydroxylase 1
Synonyms: Gros1, Lepre1, 2410024C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56401
Homologene: 10509
Shq1
Name: SHQ1 homolog (S. cerevisiae)
Synonyms: Grim-1, 2810403P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 72171
Homologene: 31683
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99003
Homologene: 11710
Kdm4a
Name: lysine (K)-specific demethylase 4A
Synonyms: D4Ertd222e, Jmjd2a, Jmjd2, JHDM3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230674
Homologene: 27780
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237954
Homologene: 138824
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 338370
VEGA: 14
Homologene: 21832
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: Myhsf1, Myhs-f1, MyHC-IIa, MHC2A, Myhs-f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Kcnq4
Name: potassium voltage-gated channel, subfamily Q, member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 60613
HGNC: HGNC:6298
Homologene: 78107
Peli2
Name: pellino 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 93834
VEGA: 14
HGNC: HGNC:8828
Homologene: 41431
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 9130019P20Rik, 1110004O12Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 108857
Homologene: 87006
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: Sdccag33, NY-CO-33, teashirt1, Tsh1, 5730407I04Rik, D18Bwg1409e, Mtsh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 110796
Homologene: 4227
Fshr
Name: follicle stimulating hormone receptor
Synonyms: FSH-R, Follitropin receptor, follicle-stimulating hormone receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14309
VEGA: 17
HGNC: HGNC:3969
Homologene: 117
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 435626
Homologene: 52359
Dnlz
Name: DNL-type zinc finger
Synonyms: D2Bwg1335e, 1110034G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 52838
Homologene: 36864
Fbxo17
Name: F-box protein 17
Synonyms: FBXO26, Fbx17, Fbg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 50760
Homologene: 17523
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
Fpr1
Name: formyl peptide receptor 1
Synonyms: fMLF-R, FPR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14293
HGNC: HGNC:3826
Homologene: 20466
Rnf31
Name: ring finger protein 31
Synonyms: Paul, HOIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 268749
Homologene: 33228
Itgax
Name: integrin alpha X
Synonyms: Cd11c, CD11C (p150) alpha polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Cpeb1
Name: cytoplasmic polyadenylation element binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12877
Homologene: 7278
Mterf1b
Name: mitochondrial transcription termination factor 1b
Synonyms: Gm9897
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 208595
Homologene: 5073
Trim52
Name: tripartite motif-containing 52
Synonyms: 4921513B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 212085
Homologene: 79723
Vwa2
Name: von Willebrand factor A domain containing 2
Synonyms: Amaco
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 240675
Homologene: 18238
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: Zfhx1b, SIP1, D130016B08Rik, 9130203F04Rik, Zfx1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 24136
Homologene: 8868
Stx5a
Name: syntaxin 5A
Synonyms: 0610031F24Rik, D19Ertd627e, syntaxin 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 56389
Homologene: 2381
Ncoa4
Name: nuclear receptor coactivator 4
Synonyms: 4432406M01Rik, 1110034E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 27057
HGNC: HGNC:7671
Homologene: 38052
Map4k2
Name: mitogen-activated protein kinase kinase kinase kinase 2
Synonyms: BL44, Rab8ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 26412
HGNC: HGNC:6864
Homologene: 3370
Olfr811
Name: olfactory receptor 811
Synonyms: MOR110-6, GA_x6K02T2PULF-11481207-11480248
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258545
Homologene: 133725
Unc93a2
Name: unc-93 homolog A2
Synonyms: Gm9992
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 667055
VEGA: 17
Homologene: 10356
Esp4
Name: exocrine gland secreted peptide 4
Synonyms: Gm20580
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 100126777
VEGA: 17
Homologene: 136356
Olfr625-ps1
Name: olfactory receptor 625, pseudogene 1
Synonyms: MOR31-15P, GA_x6K02T2PBJ9-6416276-6417237
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258169
Micall2
Name: MICAL-like 2
Synonyms: Jrab, A930021H16Rik, MICAL-L2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231830
Homologene: 85155
Agmat
Name: agmatine ureohydrolase (agmatinase)
Synonyms: 5033405N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75986
Homologene: 99855
Fam73b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 74,132,909 bp
  • C to T, chromosome 2 at 26,351,411 bp
  • T to A, chromosome 2 at 30,371,565 bp
  • T to A, chromosome 2 at 44,997,518 bp
  • C to A, chromosome 2 at 62,528,714 bp
  • T to C, chromosome 2 at 76,771,687 bp
  • C to T, chromosome 2 at 91,986,263 bp
  • A to G, chromosome 2 at 104,788,923 bp
  • T to A, chromosome 2 at 141,515,320 bp
  • T to A, chromosome 4 at 11,241,654 bp
  • A to G, chromosome 4 at 116,308,889 bp
  • A to G, chromosome 4 at 118,142,199 bp
  • A to T, chromosome 4 at 119,238,666 bp
  • A to C, chromosome 4 at 120,715,049 bp
  • G to A, chromosome 4 at 141,749,687 bp
  • T to C, chromosome 5 at 4,196,683 bp
  • C to T, chromosome 5 at 139,715,701 bp
  • A to T, chromosome 6 at 100,611,814 bp
  • C to T, chromosome 7 at 4,142,120 bp
  • A to G, chromosome 7 at 12,925,407 bp
  • G to A, chromosome 7 at 28,737,472 bp
  • A to G, chromosome 7 at 80,334,823 bp
  • A to T, chromosome 7 at 81,436,351 bp
  • A to C, chromosome 7 at 90,469,657 bp
  • G to A, chromosome 7 at 103,683,155 bp
  • T to C, chromosome 7 at 128,144,706 bp
  • G to T, chromosome 10 at 5,339,209 bp
  • A to G, chromosome 10 at 62,274,466 bp
  • G to A, chromosome 10 at 81,509,396 bp
  • C to T, chromosome 10 at 129,801,620 bp
  • A to G, chromosome 11 at 67,191,428 bp
  • C to T, chromosome 11 at 103,458,097 bp
  • T to C, chromosome 12 at 35,946,942 bp
  • G to A, chromosome 13 at 3,573,642 bp
  • C to A, chromosome 13 at 58,808,922 bp
  • T to A, chromosome 14 at 32,177,307 bp
  • G to T, chromosome 14 at 48,256,175 bp
  • C to T, chromosome 14 at 55,598,686 bp
  • C to A, chromosome 14 at 106,107,498 bp
  • T to C, chromosome 14 at 123,572,038 bp
  • C to T, chromosome 17 at 7,369,731 bp
  • T to C, chromosome 17 at 12,433,508 bp
  • T to A, chromosome 17 at 17,877,263 bp
  • C to T, chromosome 17 at 40,602,395 bp
  • T to C, chromosome 17 at 46,218,630 bp
  • T to A, chromosome 17 at 88,986,241 bp
  • T to A, chromosome 18 at 36,624,902 bp
  • A to G, chromosome 18 at 84,013,961 bp
  • T to A, chromosome 19 at 6,351,337 bp
  • T to C, chromosome 19 at 8,755,137 bp
  • G to T, chromosome 19 at 56,909,231 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5750 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043356-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.