Strain Name:
C57BL/6J-MtgxR5779Btlr
Stock Number:
043377-MU
Citation ID:
RRID:MMRRC_043377-MU
Other Names:
R5779 (G1)
Major Collection:

Gene Information

Matr3
Name: matrin 3
Synonyms: 2810017I02Rik, 1110061A14Rik, D030046F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17184
HGNC: HGNC:6912
Homologene: 7830
Ext1
Name: exostoses (multiple) 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Penk
Name: preproenkephalin
Synonyms: PPA, Penk, Penk1, ENK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18619
HGNC: HGNC:8831
Homologene: 4528
Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
Synonyms: Acra5, Acra-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110835
VEGA: 9
HGNC: HGNC:1959
Homologene: 55485
Eef1e1
Name: eukaryotic translation elongation factor 1 epsilon 1
Synonyms: 1110003A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 66143
VEGA: 13
HGNC: HGNC:3212
Homologene: 3161
Mrpl20
Name: mitochondrial ribosomal protein L20
Synonyms: 4930425I20Rik, 2610008D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66448
Homologene: 9941
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Copb1
Name: coatomer protein complex, subunit beta 1
Synonyms: 2610019B04Rik, Copb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 70349
HGNC: HGNC:2231
Homologene: 5664
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108989
Homologene: 37753
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227446
Homologene: 10834
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27103
Homologene: 40891
Ifrd1
Name: interferon-related developmental regulator 1
Synonyms: Ifnl, PC4, Tis7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15982
HGNC: HGNC:5456
Homologene: 31043
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: IP3R1, opt, Pcp1, wblo, Pcp-1, Ip3r, P400, InsP3R type I, Itpr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Hmx3
Name: H6 homeobox 3
Synonyms: Nkx5.1, Nkx5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15373
HGNC: HGNC:5019
Homologene: 40612
Kctd17
Name: potassium channel tetramerisation domain containing 17
Synonyms: 2900008M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 72844
Homologene: 23468
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, Emv66, par
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Pcgf2
Name: polycomb group ring finger 2
Synonyms: Mel18, Rnf110, Zfp144, mel-18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22658
Homologene: 5174
Scfd1
Name: Sec1 family domain containing 1
Synonyms: RA410, STXBP1L2, 3110021P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 76983
VEGA: 12
Homologene: 5650
Spag9
Name: sperm associated antigen 9
Synonyms: 3110018C07Rik, JIP4, 4831406C20Rik, Mapk8ip4, JLP, syd1, 4733401I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70834
Homologene: 2954
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Sema6A-1, sema, A730020P05Rik, VIa, Semaq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20358
Homologene: 32426
D11Wsu47e
Name: DNA segment, Chr 11, Wayne State University 47, expressed
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 276852
Homologene: 9928
Cdk12
Name: cyclin-dependent kinase 12
Synonyms: D11Ertd752e, 1810022J16Rik, Crk7, Crkrs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69131
Homologene: 128632
Nipal3
Name: NIPA-like domain containing 3
Synonyms: 9130020G22Rik, Npal3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74552
Homologene: 10722
Smg5
Name: Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229512
Homologene: 9095
Vit
Name: vitrin
Synonyms: 1700110E08Rik, akhirin, 1700052E02Rik, AKH, 2810429K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74199
VEGA: 17
Homologene: 24942
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: E030006K04Rik, Centd3, DRAG1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 106952
VEGA: 18
Homologene: 11199
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, A930037M10Rik, A930011D15Rik, LOC269160, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 110876
Homologene: 75001
Ceacam12
Name: carcinoembryonic antigen-related cell adhesion molecule 12
Synonyms: 1600031J20Rik, Ceacam12-C1, Ceacam12-C3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67315
Homologene: 137375
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 100045792
Homologene: 46005
Sik2
Name: salt inducible kinase 2
Synonyms: Snf1lk2, G630080D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235344
Homologene: 22875
Abca6
Name: ATP-binding cassette, sub-family A (ABC1), member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Fam173a
Name: family with sequence similarity 173, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 214917
VEGA: 17
Homologene: 11398
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234135
Homologene: 56960
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226438
Homologene: 130054
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
1700061G19Rik
Name: RIKEN cDNA 1700061G19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78625
Homologene: 28378
Olfr730
Name: olfactory receptor 730
Synonyms: MOR247-1, GA_x6K02T2PMLR-5881670-5880717
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258486
Homologene: 17269
Fpr-rs3
Name: formyl peptide receptor, related sequence 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14290
Homologene: 130087
Hgd
Name: homogentisate 1, 2-dioxygenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 15233
HGNC: HGNC:4892
Homologene: 156
B3gntl1
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
Synonyms: 6030413G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 210004
Homologene: 14460
Tas2r103
Name: taste receptor, type 2, member 103
Synonyms: mGR03, mt2r63, T2R3, TRB2, EG667992, Tas2r3, Tas2r10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 667992
Homologene: 130076
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Fbxo5
Name: F-box protein 5
Synonyms: Emi1, Fbxo31, 2510044I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67141
Homologene: 8135
Mpp4
Name: membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
Synonyms: DLG6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227157
Homologene: 23296
Slc36a3
Name: solute carrier family 36 (proton/amino acid symporter), member 3
Synonyms: TRAMD2, PAT3, tramdorin2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 215332
Homologene: 76175
Traf5
Name: TNF receptor-associated factor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22033
Homologene: 27079
Kbtbd8
Name: kelch repeat and BTB (POZ) domain containing 8
Synonyms: Takrp, SSEC51, SSEC-51, SSEC 51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243574
Homologene: 13043
Dcaf5
Name: DDB1 and CUL4 associated factor 5
Synonyms: BCRG2, 9430020B07Rik, Wdr22, BCRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 320808
VEGA: 12
Homologene: 18564
Npas2
Name: neuronal PAS domain protein 2
Synonyms: MOP4, bHLHe9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18143
HGNC: HGNC:7895
Homologene: 1887
Gm20499
Name: predicted gene 20499
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 39,287,571 bp
  • G to A, chromosome 1 at 59,151,666 bp
  • T to G, chromosome 1 at 105,687,347 bp
  • T to A, chromosome 1 at 135,966,840 bp
  • C to T, chromosome 1 at 150,423,541 bp
  • T to C, chromosome 1 at 188,443,510 bp
  • T to A, chromosome 1 at 191,997,672 bp
  • A to T, chromosome 2 at 52,245,301 bp
  • T to C, chromosome 2 at 65,764,483 bp
  • A to C, chromosome 2 at 118,412,963 bp
  • T to C, chromosome 3 at 88,351,618 bp
  • A to G, chromosome 4 at 4,134,318 bp
  • A to G, chromosome 4 at 135,452,339 bp
  • G to A, chromosome 4 at 155,806,921 bp
  • G to A, chromosome 5 at 114,817,021 bp
  • T to C, chromosome 6 at 95,118,534 bp
  • G to A, chromosome 6 at 108,352,143 bp
  • T to C, chromosome 6 at 133,036,945 bp
  • C to A, chromosome 7 at 18,069,154 bp
  • C to A, chromosome 7 at 102,152,361 bp
  • T to A, chromosome 7 at 114,219,572 bp
  • C to A, chromosome 7 at 131,544,328 bp
  • G to T, chromosome 8 at 25,682,669 bp
  • T to C, chromosome 9 at 50,895,845 bp
  • C to A, chromosome 9 at 54,998,104 bp
  • G to A, chromosome 10 at 5,800,303 bp
  • T to A, chromosome 10 at 18,163,438 bp
  • A to T, chromosome 11 at 55,135,268 bp
  • A to G, chromosome 11 at 94,114,253 bp
  • G to A, chromosome 11 at 97,690,291 bp
  • T to A, chromosome 11 at 98,219,074 bp
  • T to C, chromosome 11 at 110,184,670 bp
  • A to G, chromosome 11 at 113,687,992 bp
  • G to T, chromosome 11 at 121,651,676 bp
  • A to T, chromosome 12 at 40,203,370 bp
  • A to G, chromosome 12 at 51,431,529 bp
  • C to T, chromosome 12 at 80,338,832 bp
  • T to C, chromosome 13 at 38,646,273 bp
  • A to T, chromosome 14 at 50,186,746 bp
  • C to A, chromosome 14 at 62,414,301 bp
  • A to G, chromosome 15 at 53,344,553 bp
  • A to T, chromosome 15 at 78,437,133 bp
  • T to A, chromosome 16 at 37,593,371 bp
  • C to A, chromosome 17 at 20,624,226 bp
  • A to G, chromosome 17 at 25,790,657 bp
  • A to T, chromosome 17 at 56,881,061 bp
  • A to G, chromosome 17 at 78,546,426 bp
  • T to C, chromosome 18 at 35,584,522 bp
  • T to C, chromosome 18 at 37,301,467 bp
  • T to C, chromosome 18 at 37,984,365 bp
  • G to A, chromosome 18 at 47,248,826 bp
  • T to C, chromosome 18 at 67,440,443 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5779 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043377-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.