Strain Name:
C57BL/6J-MtgxR5781Btlr
Stock Number:
043378-MU
Citation ID:
RRID:MMRRC_043378-MU
Other Names:
R5781 (G1)
Major Collection:

Gene Information

Hyal1
Name: hyaluronoglucosaminidase 1
Synonyms: Hyal-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15586
HGNC: HGNC:5320
Homologene: 5277
Tgfb1
Name: transforming growth factor, beta 1
Synonyms: Tgfb-1, Tgfb, TGFbeta1, TGF-beta1, TGF-beta 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21803
Homologene: 540
Msx2
Name: msh homeobox 2
Synonyms: Hox8.1, Hox-8, Hox8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17702
HGNC: HGNC:7392
Homologene: 1837
Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: PSGAP-m, PSGAP-s, A930033B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78514
Homologene: 12695
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd, Edd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Hspa12a
Name: heat shock protein 12A
Synonyms: Hspa12a, 1700063D12Rik, Gm19925
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73442
VEGA: 19
Homologene: 18422
Pnn
Name: pinin
Synonyms: D12Ertd512e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18949
VEGA: 12
HGNC: HGNC:9162
Homologene: 37656
Arhgef18
Name: rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms: A430078G23Rik, D030053O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319493
Homologene: 32254
Dhdds
Name: dehydrodolichyl diphosphate synthase
Synonyms: 3222401G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67422
Homologene: 32615
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: Mll, Cxxc7, HTRX1, Mll1, ALL-1, All1, trithorax Drosophila
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: InsP3R type I, Itpr-1, wblo, IP3R1, opt, P400, Pcp-1, Ip3r, Pcp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: Coh1, C330002D13Rik, 1810042B05Rik, 2310042E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, Zubr1, D930005K06Rik, 1810009A16Rik, A930005E13Rik, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, Zfp650, 1110059H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68795
Homologene: 52092
Rfwd3
Name: ring finger and WD repeat domain 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234736
Homologene: 41230
Rbmxl1
Name: RNA binding motif protein, X-linked like-1
Synonyms: hnRNP G, Hnrpg, Rbmxrt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19656
Homologene: 84779
Adamts4
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
Synonyms: ADAM-TS4, aggrecanase-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240913
HGNC: HGNC:220
Homologene: 36169
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142682
Homologene: 9037
Fyco1
Name: FYVE and coiled-coil domain containing 1
Synonyms: 2810409M01Rik, ZFYVE7, Mem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17281
Homologene: 11561
Sctr
Name: secretin receptor
Synonyms: 6530402O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319229
Homologene: 68290
Mlycd
Name: malonyl-CoA decarboxylase
Synonyms: Mcd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56690
HGNC: HGNC:7150
Homologene: 40821
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Fetub
Name: fetuin beta
Synonyms: 2310011O17Rik, D17980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 59083
VEGA: 16
HGNC: HGNC:3658
Homologene: 8660
Plcl1
Name: phospholipase C-like 1
Synonyms: PRIP-1, C230017K02Rik, PLC-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227120
HGNC: HGNC:9063
Homologene: 38155
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Adamts19
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240322
VEGA: 18
Homologene: 15860
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330222
Homologene: 27395
Asb15
Name: ankyrin repeat and SOCS box-containing 15
Synonyms: 4930400E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78910
Homologene: 43797
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224916
Mc2r
Name: melanocortin 2 receptor
Synonyms: adrenocorticotropic hormone receptor, Acthr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17200
VEGA: 18
HGNC: HGNC:6930
Homologene: 444
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 9130206N08Rik, 2010013I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103406
Homologene: 88124
Evc
Name: EvC ciliary complex subunit 1
Synonyms: Ellis van Creveld gene syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 59056
HGNC: HGNC:3497
Homologene: 10949
Hkdc1
Name: hexokinase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216019
Homologene: 128937
Recql
Name: RecQ protein-like
Synonyms: RecQ1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19691
HGNC: HGNC:9948
Homologene: 56279
Cnot6l
Name: CCR4-NOT transcription complex, subunit 6-like
Synonyms: 4932442K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231464
Homologene: 100830
Hpdl
Name: 4-hydroxyphenylpyruvate dioxygenase-like
Synonyms: A830048M07Rik, Gloxd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242642
Homologene: 13109
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71481
Homologene: 11849
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: 6230416J20Rik, D4Ertd27e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230376
Homologene: 9760
Smpdl3a
Name: sphingomyelin phosphodiesterase, acid-like 3A
Synonyms: ASM3A, ASML3A, 0610010C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 57319
Homologene: 4886
Pla2g4f
Name: phospholipase A2, group IVF
Synonyms: Pla2zeta, 4732472I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271844
Homologene: 77933
Olfr770
Name: olfactory receptor 770
Synonyms: MOR114-5, GA_x6K02T2PULF-10819232-10818297
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258862
Homologene: 27285
Tbc1d12
Name: TBC1D12: TBC1 domain family, member 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 209478
VEGA: 19
Homologene: 50835
Mocs2
Name: molybdenum cofactor synthesis 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17434
HGNC: HGNC:7193
Homologene: 32193
Abhd16b
Name: abhydrolase domain containing 16B
Synonyms: BC050777
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241850
Homologene: 15422
Spag6
Name: sperm associated antigen 6
Synonyms: Spag6l, BC061194
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381350
Homologene: 133723
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 55,695,989 bp
  • A to G, chromosome 1 at 120,031,620 bp
  • T to C, chromosome 1 at 171,251,015 bp
  • A to G, chromosome 2 at 18,731,993 bp
  • G to T, chromosome 2 at 70,016,244 bp
  • C to A, chromosome 2 at 120,305,023 bp
  • T to C, chromosome 2 at 181,494,154 bp
  • A to C, chromosome 3 at 127,680,035 bp
  • C to T, chromosome 4 at 86,601,263 bp
  • C to T, chromosome 4 at 116,820,578 bp
  • G to A, chromosome 4 at 133,996,830 bp
  • T to C, chromosome 4 at 139,468,096 bp
  • A to T, chromosome 5 at 37,326,570 bp
  • A to C, chromosome 5 at 96,086,165 bp
  • T to A, chromosome 5 at 141,936,048 bp
  • A to T, chromosome 6 at 24,564,378 bp
  • G to A, chromosome 6 at 108,510,738 bp
  • G to T, chromosome 6 at 142,365,618 bp
  • A to G, chromosome 7 at 25,696,960 bp
  • T to A, chromosome 8 at 3,439,439 bp
  • G to T, chromosome 8 at 77,450,707 bp
  • G to A, chromosome 8 at 78,505,641 bp
  • G to A, chromosome 8 at 111,273,084 bp
  • A to G, chromosome 8 at 119,410,280 bp
  • A to T, chromosome 8 at 121,604,593 bp
  • A to T, chromosome 9 at 44,847,842 bp
  • C to T, chromosome 9 at 107,577,667 bp
  • A to G, chromosome 9 at 123,794,833 bp
  • T to A, chromosome 10 at 39,823,093 bp
  • T to A, chromosome 10 at 50,637,978 bp
  • T to A, chromosome 10 at 57,807,938 bp
  • T to G, chromosome 10 at 62,417,933 bp
  • T to A, chromosome 10 at 81,243,713 bp
  • A to T, chromosome 10 at 129,133,147 bp
  • A to G, chromosome 11 at 110,101,987 bp
  • T to C, chromosome 12 at 59,071,819 bp
  • C to A, chromosome 13 at 53,472,608 bp
  • T to G, chromosome 13 at 114,820,919 bp
  • G to T, chromosome 15 at 35,794,035 bp
  • T to C, chromosome 15 at 38,006,541 bp
  • A to G, chromosome 15 at 55,423,512 bp
  • C to T, chromosome 16 at 22,932,331 bp
  • T to G, chromosome 17 at 57,524,938 bp
  • A to G, chromosome 18 at 20,032,510 bp
  • G to T, chromosome 18 at 58,837,968 bp
  • A to T, chromosome 18 at 68,407,395 bp
  • A to T, chromosome 18 at 68,407,397 bp
  • A to C, chromosome 19 at 38,882,683 bp
  • T to C, chromosome 19 at 58,822,086 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5781 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043378-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.