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Strain Name:
C57BL/6J-MtgxR5788Btlr
Stock Number:
043382-MU
Citation ID:
RRID:MMRRC_043382-MU
Other Names:
R5788 (G1)
Major Collection:

Strain Information

Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: separase, SSE, ESP1, PRCE, PRCE, Cerp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Ckm
Name: creatine kinase, muscle
Synonyms: M-CK, MCK, Ckmm
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12715
HGNC: HGNC:1994
Homologene: 20432
Kcns2
Name: K+ voltage-gated channel, subfamily S, 2
Synonyms: Kv9.2, E130006J24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16539
VEGA: 15
HGNC: HGNC:6301
Homologene: 22465
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Hcn2
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Synonyms: HAC1, trls
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15166
HGNC: HGNC:4846
Homologene: 31022
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, D10Ertd17e, Cxxc6, BB001228
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms: 4930470P14Rik, 9530057A13Rik, 4932439K10Rik, Specc1l, Cytsa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74392
VEGA: 10
Homologene: 15610
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 97,243,476 bp
  • A to T, chromosome 1 at 153,851,064 bp
  • A to T, chromosome 1 at 166,409,011 bp
  • A to G, chromosome 1 at 171,239,385 bp
  • A to T, chromosome 2 at 76,919,231 bp
  • A to G, chromosome 2 at 87,002,301 bp
  • T to A, chromosome 2 at 118,122,508 bp
  • TGGCCACGCGG to TGG, chromosome 2 at 173,578,089 bp
  • C to T, chromosome 3 at 88,245,567 bp
  • A to T, chromosome 3 at 93,200,989 bp
  • A to T, chromosome 4 at 43,007,130 bp
  • C to T, chromosome 4 at 106,760,130 bp
  • T to C, chromosome 5 at 63,807,771 bp
  • T to A, chromosome 5 at 66,676,411 bp
  • A to G, chromosome 5 at 117,377,418 bp
  • T to A, chromosome 6 at 42,405,597 bp
  • T to C, chromosome 6 at 135,740,964 bp
  • T to C, chromosome 6 at 149,484,000 bp
  • A to G, chromosome 7 at 19,419,447 bp
  • T to A, chromosome 7 at 39,172,203 bp
  • G to A, chromosome 7 at 51,566,318 bp
  • C to T, chromosome 7 at 103,460,879 bp
  • T to C, chromosome 7 at 108,545,344 bp
  • A to G, chromosome 7 at 131,443,599 bp
  • A to T, chromosome 8 at 4,206,800 bp
  • C to T, chromosome 8 at 13,100,320 bp
  • T to C, chromosome 8 at 16,201,966 bp
  • T to C, chromosome 8 at 22,625,331 bp
  • T to A, chromosome 8 at 94,000,314 bp
  • A to G, chromosome 9 at 15,084,283 bp
  • A to G, chromosome 9 at 20,506,036 bp
  • C to T, chromosome 9 at 44,297,808 bp
  • T to C, chromosome 10 at 62,839,958 bp
  • G to T, chromosome 10 at 75,276,921 bp
  • T to C, chromosome 10 at 79,717,111 bp
  • G to A, chromosome 10 at 128,040,142 bp
  • A to T, chromosome 10 at 129,500,894 bp
  • A to G, chromosome 10 at 129,500,910 bp
  • A to G, chromosome 11 at 6,271,743 bp
  • A to G, chromosome 11 at 59,487,260 bp
  • T to G, chromosome 11 at 62,753,281 bp
  • T to A, chromosome 11 at 70,708,828 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • A to T, chromosome 11 at 102,605,467 bp
  • A to G, chromosome 11 at 120,286,352 bp
  • G to C, chromosome 12 at 81,377,830 bp
  • A to C, chromosome 12 at 112,764,117 bp
  • G to T, chromosome 13 at 100,300,216 bp
  • C to T, chromosome 14 at 27,498,491 bp
  • C to T, chromosome 14 at 55,628,820 bp
  • T to A, chromosome 14 at 60,020,793 bp
  • A to G, chromosome 15 at 11,036,164 bp
  • A to C, chromosome 15 at 34,838,854 bp
  • T to G, chromosome 15 at 91,764,648 bp
  • T to A, chromosome 15 at 102,324,030 bp
  • A to G, chromosome 16 at 91,660,052 bp
  • G to A, chromosome 18 at 50,173,709 bp
  • T to G, chromosome 19 at 10,540,718 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5788 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043382-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.