Strain Name:
C57BL/6J-MtgxR5789Btlr
Stock Number:
043383-MU
Citation ID:
RRID:MMRRC_043383-MU
Other Names:
R5789 (G1)
Major Collection:

Gene Information

Cops3
Name: COP9 signalosome subunit 3
Synonyms: Sgn3, COP9 complex S3, Csn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26572
HGNC: HGNC:2239
Homologene: 2710
Socs3
Name: suppressor of cytokine signaling 3
Synonyms: EF-10, SOCS-3, cytokine-inducible SH2 protein 3, CIS3, STAT-induced STAT inhibitor 3, SSI-3, E2a-Pbx1 target gene in fibroblasts 10, Cish3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12702
Homologene: 2941
Dclre1c
Name: DNA cross-link repair 1C
Synonyms: 9930121L06Rik, Artemis, Art
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227525
Homologene: 32547
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: P19-PTP, PTP-PEST, PTP-P19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Wasf1
Name: WASP family, member 1
Synonyms: WAVE-1, Scar, WAVE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83767
Homologene: 2920
Xpnpep3
Name: X-prolyl aminopeptidase 3, mitochondrial
Synonyms: E430012M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 321003
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
Tcf12
Name: transcription factor 12
Synonyms: ME1, ALF1, HEB, HTF4, HTF-4, REB, bHLHb20, HEBAlt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21406
Homologene: 40774
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, HTRX1, ALL-1, All1, Cxxc7, Mll, Mll1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Yars
Name: tyrosyl-tRNA synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107271
Homologene: 2730
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, mBSC2, Nkcc1, sy-ns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Mtrex
Name: Mtr4 exosome RNA helicase
Synonyms: 2610528A15Rik, Skiv2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72198
VEGA: 13
Homologene: 6257
Zfp90
Name: zinc finger protein 90
Synonyms: Nk10 expressed protein, NK10, 6430515L01Rik, Zfp64, KRAB17, Zfp83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22751
Homologene: 86800
Tmem135
Name: transmembrane protein 135
Synonyms: 2810439K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72759
Homologene: 11295
Supt6
Name: SPT6, histone chaperone and transcription elongation factor
Synonyms: SPT6, 5131400N11Rik, Supt6h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20926
Homologene: 40661
Cdan1
Name: congenital dyserythropoietic anemia, type I (human)
Synonyms: CDA-I, CDA1, 1500015A01Rik, codanin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Fam180a
Name: family with sequence similarity 180, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 208164
Homologene: 18283
Gfral
Name: GDNF family receptor alpha like
Synonyms: GRAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404194
Homologene: 45748
Tmem170
Name: transmembrane protein 170
Synonyms: 9030409E16Rik, D8Bwg1414e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66817
Homologene: 12040
Coq7
Name: demethyl-Q 7
Synonyms: clk-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12850
HGNC: HGNC:2244
Homologene: 6953
Eif2b3
Name: eukaryotic translation initiation factor 2B, subunit 3
Synonyms: 1190002P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 108067
HGNC: HGNC:3259
Homologene: 7005
Inpp4a
Name: inositol polyphosphate-4-phosphatase, type I
Synonyms: 107kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269180
HGNC: HGNC:6074
Homologene: 2871
Zscan22
Name: zinc finger and SCAN domain containing 22
Synonyms: D530006B18Rik, Hkr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232878
HGNC: HGNC:4929
Homologene: 68122
Dhx37
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 37
Synonyms: LOC208144, LOC381671
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208144
Homologene: 6641
Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Synonyms: PC-1, NPP1, Npps, Pca-1, Pca, Ly-41, Pdnp1, twy, CD203c, E-NPP1, 4833416E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18605
HGNC: HGNC:3356
Homologene: 38151
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: Rme8, LOC382100, D030002L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235567
Homologene: 13574
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77505
Homologene: 131117
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms: PFIC2, ABC16, PGY4, Lith1, sister of P-glycoprotein, Bsep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Nckap5
Name: NCK-associated protein 5
Synonyms: LOC380609, D130011D22Rik, E030049G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210356
Homologene: 35542
Uroc1
Name: urocanase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243537
Homologene: 76629
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665033
Homologene: 122792
Ciao3
Name: cytosolic iron-sulfur assembly component 3
Synonyms: 9030612I22Rik, Narfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67563
Homologene: 6750
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228846
Homologene: 18598
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Aqp1
Name: aquaporin 1
Synonyms: CHIP28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11826
HGNC: HGNC:633
Homologene: 68051
Sh2d2a
Name: SH2 domain containing 2A
Synonyms: TSAd, Lck-associated adapter protein, Lad, RIBP, Rlk/Itk-binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 27371
Homologene: 2958
C9orf72
Name: C9orf72, member of C9orf72-SMCR8 complex
Synonyms: 3110043O21Rik, Dennd9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73205
Homologene: 10137
Doc2b
Name: double C2, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13447
HGNC: HGNC:2986
Homologene: 20796
Nudcd1
Name: NudC domain containing 1
Synonyms: 4921532K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67429
VEGA: 15
Homologene: 12128
Samsn1
Name: SAM domain, SH3 domain and nuclear localization signals, 1
Synonyms: 4930571B16Rik, Hacs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67742
Homologene: 11148
Gabra1
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
Synonyms: GABAA alpha 1, Gabra-1, GABAAR alpha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Them5
Name: thioesterase superfamily member 5
Synonyms: 1110007B02Rik, 1110038F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66198
Homologene: 11931
Ifi213
Name: interferon activated gene 213
Synonyms: E030037K03Rik, Pydc4, Pyr-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 623121
HGNC: HGNC:5395
Homologene: 115929
Plekhb1
Name: pleckstrin homology domain containing, family B (evectins) member 1
Synonyms: PHR1, Phret1, evt-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27276
Homologene: 8449
Zdhhc16
Name: zinc finger, DHHC domain containing 16
Synonyms: APH2, 1500015N03Rik, Abl-philin 2, Ablphilin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74168
VEGA: 19
Homologene: 11377
Aloxe3
Name: arachidonate lipoxygenase 3
Synonyms: e-LOX-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23801
Homologene: 8013
Prrt1
Name: proline-rich transmembrane protein 1
Synonyms: G5b, NG5, SynDIG4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 260297
Homologene: 134500
Trbv20
Name: T cell receptor beta, variable 20
Synonyms: Tcrb-V15, Gm16911
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100124685
Gm16551
Name: predicted gene 16551
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100503019
Pcdhgc5
Name: protocadherin gamma subfamily C, 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93708
HGNC: HGNC:8718
Homologene: 110933
Mrgprb13
Name: MAS-related GPR, member B13
Synonyms: MrgB13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620137
Homologene: 83620
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,372,329 bp
  • A to G, chromosome 1 at 126,027,702 bp
  • C to A, chromosome 1 at 173,568,794 bp
  • A to T, chromosome 2 at 3,437,956 bp
  • A to G, chromosome 2 at 69,245,764 bp
  • A to G, chromosome 2 at 120,729,535 bp
  • C to T, chromosome 2 at 158,216,814 bp
  • T to A, chromosome 3 at 19,957,290 bp
  • T to A, chromosome 3 at 87,849,513 bp
  • A to G, chromosome 3 at 94,346,601 bp
  • T to A, chromosome 4 at 35,226,112 bp
  • T to A, chromosome 4 at 117,028,495 bp
  • C to T, chromosome 4 at 129,196,897 bp
  • G to A, chromosome 5 at 20,989,015 bp
  • A to C, chromosome 5 at 125,421,039 bp
  • C to A, chromosome 6 at 35,313,526 bp
  • A to G, chromosome 6 at 41,188,791 bp
  • A to G, chromosome 6 at 55,336,761 bp
  • A to G, chromosome 6 at 90,344,197 bp
  • T to G, chromosome 7 at 12,903,926 bp
  • A to T, chromosome 7 at 48,312,198 bp
  • A to G, chromosome 7 at 89,196,122 bp
  • A to T, chromosome 7 at 100,645,586 bp
  • A to G, chromosome 7 at 105,705,010 bp
  • G to T, chromosome 7 at 118,529,706 bp
  • G to T, chromosome 7 at 119,943,599 bp
  • T to C, chromosome 8 at 106,423,973 bp
  • A to G, chromosome 8 at 111,866,400 bp
  • T to C, chromosome 9 at 44,819,904 bp
  • T to C, chromosome 9 at 71,885,236 bp
  • T to A, chromosome 9 at 74,849,253 bp
  • C to T, chromosome 9 at 76,197,046 bp
  • T to C, chromosome 9 at 104,214,188 bp
  • T to C, chromosome 9 at 105,864,608 bp
  • A to T, chromosome 10 at 24,647,239 bp
  • G to A, chromosome 10 at 40,926,574 bp
  • T to A, chromosome 10 at 76,604,389 bp
  • A to T, chromosome 11 at 42,182,915 bp
  • T to C, chromosome 11 at 59,830,280 bp
  • T to C, chromosome 11 at 69,126,439 bp
  • T to A, chromosome 11 at 75,786,115 bp
  • A to G, chromosome 11 at 78,233,586 bp
  • T to A, chromosome 11 at 117,967,782 bp
  • A to G, chromosome 13 at 24,121,848 bp
  • A to T, chromosome 13 at 112,891,285 bp
  • G to A, chromosome 15 at 44,388,483 bp
  • T to A, chromosome 15 at 81,415,864 bp
  • T to C, chromosome 16 at 75,876,448 bp
  • T to C, chromosome 17 at 25,781,203 bp
  • T to C, chromosome 17 at 34,631,957 bp
  • C to A, chromosome 18 at 37,821,506 bp
  • T to A, chromosome 18 at 57,912,019 bp
  • A to T, chromosome 19 at 9,002,321 bp
  • T to A, chromosome 19 at 41,938,133 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5789 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043383-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.