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Strain Name:
C57BL/6J-MtgxR5809Btlr/Mmmh
Stock Number:
043394-MU
Citation ID:
RRID:MMRRC_043394-MU
Other Names:
R5809 (G1)
Major Collection:

Strain Information

Scarb1
Name: scavenger receptor class B, member 1
Synonyms: D5Ertd460e, Srb1, Cd36l1, Cla-1, SRBI, SR-BI, Hlb398, Hdlq1, Chohd1, Chohd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Ndrg1
Name: N-myc downstream regulated gene 1
Synonyms: Tdd5, PROXY1, CMT4D, CAP43, TDD5, DRG1, Ndr1, Ndrl
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17988
HGNC: HGNC:7679
Homologene: 55953
Blm
Name: Bloom syndrome, RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12144
HGNC: HGNC:1058
Homologene: 47902
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Hsp90ab1
Name: heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms: Hsp84, Hsp90, Hsp84-1, C81438, Hspcb
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15516
Homologene: 74306
Zmat5
Name: zinc finger, matrin type 5
Synonyms: D11Bwg1548e, D11Bwg0572e, 2610510L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67178
Homologene: 32439
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 52,853,700 bp
  • T to A, chromosome 1 at 55,696,001 bp
  • A to G, chromosome 1 at 63,305,876 bp
  • A to G, chromosome 1 at 72,591,137 bp
  • G to A, chromosome 1 at 87,126,548 bp
  • G to A, chromosome 1 at 150,649,607 bp
  • A to T, chromosome 1 at 155,933,341 bp
  • T to C, chromosome 1 at 172,130,739 bp
  • T to A, chromosome 2 at 58,823,645 bp
  • A to G, chromosome 2 at 69,965,511 bp
  • T to C, chromosome 2 at 135,262,244 bp
  • T to A, chromosome 2 at 178,460,126 bp
  • A to G, chromosome 2 at 181,511,579 bp
  • A to C, chromosome 3 at 40,679,590 bp
  • A to T, chromosome 3 at 53,857,882 bp
  • A to T, chromosome 3 at 68,695,262 bp
  • A to G, chromosome 3 at 88,708,885 bp
  • A to T, chromosome 3 at 89,141,784 bp
  • A to T, chromosome 3 at 93,445,573 bp
  • A to G, chromosome 4 at 58,116,524 bp
  • G to A, chromosome 4 at 58,946,481 bp
  • C to T, chromosome 4 at 131,785,756 bp
  • C to T, chromosome 4 at 132,075,147 bp
  • A to G, chromosome 4 at 139,830,371 bp
  • T to A, chromosome 4 at 141,825,553 bp
  • T to C, chromosome 5 at 65,075,607 bp
  • G to A, chromosome 5 at 88,108,840 bp
  • A to G, chromosome 5 at 110,237,990 bp
  • A to G, chromosome 5 at 125,304,222 bp
  • C to T, chromosome 6 at 35,512,290 bp
  • T to C, chromosome 6 at 38,115,654 bp
  • G to T, chromosome 6 at 48,460,045 bp
  • A to G, chromosome 6 at 130,179,073 bp
  • A to G, chromosome 6 at 146,576,349 bp
  • T to C, chromosome 6 at 147,257,247 bp
  • A to G, chromosome 7 at 35,417,726 bp
  • A to T, chromosome 7 at 80,464,844 bp
  • A to G, chromosome 8 at 12,279,556 bp
  • C to T, chromosome 9 at 35,789,001 bp
  • T to A, chromosome 9 at 37,384,805 bp
  • A to C, chromosome 9 at 54,539,576 bp
  • G to A, chromosome 9 at 121,909,474 bp
  • A to G, chromosome 11 at 4,722,431 bp
  • T to C, chromosome 11 at 5,870,257 bp
  • T to A, chromosome 11 at 9,293,692 bp
  • T to C, chromosome 11 at 31,872,801 bp
  • T to G, chromosome 11 at 34,262,445 bp
  • T to C, chromosome 11 at 53,433,554 bp
  • C to A, chromosome 11 at 70,350,882 bp
  • T to C, chromosome 11 at 74,661,700 bp
  • A to T, chromosome 11 at 78,397,821 bp
  • T to C, chromosome 11 at 94,813,002 bp
  • A to T, chromosome 12 at 79,078,687 bp
  • T to A, chromosome 13 at 49,901,888 bp
  • T to A, chromosome 14 at 31,743,354 bp
  • T to C, chromosome 14 at 50,425,448 bp
  • T to C, chromosome 15 at 30,847,377 bp
  • A to G, chromosome 15 at 44,519,707 bp
  • A to G, chromosome 15 at 66,930,850 bp
  • G to T, chromosome 15 at 89,167,571 bp
  • T to A, chromosome 16 at 29,433,987 bp
  • T to C, chromosome 16 at 58,926,497 bp
  • C to A, chromosome 16 at 90,475,903 bp
  • T to C, chromosome 16 at 91,687,850 bp
  • A to G, chromosome 17 at 13,226,978 bp
  • A to T, chromosome 17 at 14,883,669 bp
  • G to A, chromosome 17 at 24,504,547 bp
  • G to T, chromosome 17 at 45,570,649 bp
  • T to C, chromosome 17 at 46,668,006 bp
  • A to C, chromosome 17 at 74,670,374 bp
  • C to T, chromosome 18 at 20,818,082 bp
  • A to G, chromosome 19 at 11,504,884 bp
  • A to T, chromosome 19 at 47,093,808 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5809 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043394-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.