Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR5819Btlr/Mmmh
Stock Number:
043399-MU
Citation ID:
RRID:MMRRC_043399-MU
Other Names:
R5819 (G1)
Major Collection:

Strain Information

S1pr1
Name: sphingosine-1-phosphate receptor 1
Synonyms: S1P1, S1P, Edg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13609
HGNC: HGNC:3165
Homologene: 1071
Aggf1
Name: angiogenic factor with G patch and FHA domains 1
Synonyms: 2310029P06Rik, VG5Q, 2010009L17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66549
Homologene: 41220
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Phf14
Name: PHD finger protein 14
Synonyms: 1110001C23Rik, 4932409F11Rik, 5730446A07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75725
Homologene: 8775
Mov10
Name: Mov10 RISC complex RNA helicase
Synonyms: Mov-10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17454
HGNC: HGNC:7200
Homologene: 10365
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: 53BP1, p53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 44,009,722 bp
  • T to C, chromosome 1 at 133,897,879 bp
  • A to G, chromosome 2 at 76,658,369 bp
  • A to T, chromosome 2 at 111,230,959 bp
  • A to C, chromosome 2 at 119,941,263 bp
  • G to A, chromosome 2 at 121,208,392 bp
  • A to T, chromosome 3 at 37,048,600 bp
  • G to A, chromosome 3 at 55,489,864 bp
  • A to G, chromosome 3 at 93,073,732 bp
  • C to T, chromosome 3 at 104,801,512 bp
  • G to T, chromosome 3 at 115,712,140 bp
  • T to A, chromosome 3 at 117,325,864 bp
  • A to T, chromosome 3 at 122,136,981 bp
  • T to C, chromosome 3 at 152,220,553 bp
  • TTTAATGAAGAGCT to TT, chromosome 4 at 34,771,261 bp
  • A to G, chromosome 4 at 132,325,210 bp
  • A to G, chromosome 5 at 25,409,132 bp
  • T to A, chromosome 5 at 41,832,605 bp
  • T to A, chromosome 5 at 109,174,100 bp
  • A to G, chromosome 6 at 11,997,252 bp
  • C to T, chromosome 6 at 48,037,588 bp
  • A to T, chromosome 6 at 55,897,891 bp
  • A to C, chromosome 6 at 88,483,115 bp
  • T to C, chromosome 7 at 4,969,997 bp
  • T to A, chromosome 7 at 31,360,214 bp
  • A to G, chromosome 7 at 55,879,151 bp
  • G to A, chromosome 7 at 104,141,467 bp
  • T to C, chromosome 7 at 130,981,739 bp
  • A to T, chromosome 9 at 21,981,602 bp
  • T to A, chromosome 9 at 36,710,405 bp
  • T to A, chromosome 9 at 49,114,479 bp
  • G to A, chromosome 9 at 108,451,062 bp
  • A to T, chromosome 10 at 29,197,273 bp
  • T to A, chromosome 10 at 99,110,030 bp
  • T to A, chromosome 10 at 107,719,883 bp
  • T to C, chromosome 10 at 127,009,998 bp
  • T to C, chromosome 12 at 3,992,965 bp
  • T to A, chromosome 12 at 98,216,261 bp
  • T to C, chromosome 13 at 95,351,621 bp
  • T to G, chromosome 14 at 16,443,820 bp
  • T to A, chromosome 14 at 28,141,369 bp
  • G to T, chromosome 14 at 44,521,529 bp
  • C to A, chromosome 15 at 6,815,787 bp
  • T to C, chromosome 15 at 32,177,306 bp
  • A to T, chromosome 17 at 28,069,236 bp
  • A to G, chromosome 19 at 6,109,654 bp
  • C to A, chromosome 19 at 10,968,690 bp
  • A to G, chromosome 19 at 31,585,672 bp
  • A to G, chromosome 19 at 42,183,496 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5819 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043399-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.