Strain Name:
C57BL/6J-Ctnna1Tvrm5/PjnMmjax
Stock Number:
043572-JAX
Citation ID:
RRID:MMRRC_043572-JAX
Other Names:
C57BL/6J-Ctnna1Tvrm5/Pjn

Strain Information

Ctnna1Tvrm5
Name: catenin alpha 1; translational vision research model 5
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
Ctnna1
Name: catenin alpha 1
Synonyms: catenin (cadherin associated protein), alpha 1, 2010010M04Rik, alpha E catenin, alpha(E)-catenin, Catna1
Type: Gene
Species: Mouse
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 12385
VEGA: 18
HGNC: HGNC:2509
Homologene: 1433
Genetic Alterations
This ENU induced T to C transition results in a leucine to proline mutation at amino acid 436.
Phenotype
homozygous: abnormal retinal pigment epithelium pigmentation and morphology, abnormal electroretinography rod a-wave, b-wave, and c-wave shape, retinal spots, retinal degeneration. Heterozygous: same phenotype but later in onset.
Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )

Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact csmmrrc@jax.org. Older strains may not have this information.
  • Sensorineural
  • Models for Human Disease
      • patterned macular dystrophy 2
    Donor
    Patsy Nishina, Ph.D., Jackson Laboratories.
    Primary Reference
    J:227177 Saksens NT, et al., Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity. Nat Genet. 2015 Dec 21

    Colony and Husbandry Information

    Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email csmmrrc@jax.org.
    Coat Color
    Black
    MMRRC Breeding System
    Sib-mating
    Breeding Scheme(s)
    • Heterozygous female x Heterozygous male from the colony
      Generation
      N+2F1
      Overall Breeding Performance
      Poor
      Viability and Fertility: Female Male Comments
      Homozygotes are viable: Yes Yes
      Homozygotes are fertile: Reduced Reduced Males do not breed well.
      Heterozygotes are fertile: Yes Yes Select One
      Age Reproductive Decline: Undetermined Undetermined
      Bred to Homozygosity
      Yes
      Average litter size
      <4
      Recommended wean age
      3-4 weeks
      Average Pups Weaned
      <4

      Order Request Information

      Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

      Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.

      Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

      Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

      Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
      MMRRC Item # Description Distribution Fee / Unit (US $)
      *Shipping & Handling not included*
      Units Notes
      043572-JAX-SPERM Cryo-preserved spermatozoa $437.00 / $437.00
      Non-Profit / For-Profit
      Aliquot Approximate quantity3
      043572-JAX-RESUS Litter recovered from cryo-archive $2,022.00 / $2,022.00
      Non-Profit / For-Profit
      Litter Recovered litter4; additional fees for any special requests.
      Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.

      1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

      2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

      3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

      4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

      To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.