Strain Name:
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Gene Information

Allele Symbol: Las1lem1(IMPC)J (Mus musculus (mouse))
Name: endonuclease-mediated mutation 1, Jackson
Alteration at locus: Targeted Mutation
Monarch Initiative (Disease and Phenotype Associations): MGI:6107678
Gene Symbol: Las1l (Mus musculus (mouse))
Name: LAS1-like (S. cerevisiae)
Synonyms: 5830482G23Rik, 1810030A06Rik
Chromosome: X
Alteration at locus: Targeted Mutation
Monarch Initiative (Disease and Phenotype Associations): MGI:1923380
Genetic Alterations
intragenic deletion
ES Cell Line
MeSH Terms
    Strain Development
    This allele was generated at The Jackson Laboratory by injecting Cas9 RNA, 4 guide sequences TGAAATAGTATGTTCCACGA, CCTTACCCCATGACCTACTT, GCTGACACCAAGCATAAGAA and CCCACCCCAACATTTACTAA, and a single strand oligo containing a loxP flanked exon 3 sequence. The integration of sequence from this single stranded oligo resulted in the insertion of loxP sites flanking ENSMUSE00001265601 (exon 3) starting at Chromosome X negative strand position 95,955,321 bp and ending after 95,955,101. There are no additional changes other than the insertion of the 2 loxP sites.
    Suggested Control Mice
    C57BL/6NJ or wild-type from colony
    Stephen Murray, Ph.D., The Jackson Laboratory.

    Colony and Husbandry Information

    Mice derived from requested cell lines via Microinjection services will be pathogen tested prior to delivery of mice and health reports will be provided. If you require additional health status information prior to requesting microinjection please email
    Coat Color
    Overall Breeding Performance
    Viability and Fertility: Female Male Comments
    Homozygotes are viable: Undetermined Undetermined Undetermined
    Homozygotes are fertile: Undetermined Undetermined Undetermined
    Heterozygotes are fertile: Undetermined Undetermined Undetermined
    Age Reproductive Decline: Undetermined Undetermined

    Order Request Information

    The availability level for this product has not been determined.

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