Strain Name:
C57BL/6J-MtgxR5835Btlr
Stock Number:
044056-MU
Citation ID:
RRID:MMRRC_044056-MU
Other Names:
R5835 (G1)
Major Collection:

Gene Information

Slc1a2
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Synonyms: 1700091C19Rik, MGLT1, GLT1, Eaat2, 2900019G14Rik, GLT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20511
Homologene: 3075
Sfrp1
Name: secreted frizzled-related protein 1
Synonyms: 2210415K03Rik, sFRP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20377
Homologene: 2266
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: Bat2l, 5830434P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227723
Homologene: 106649
Rybp
Name: RING1 and YY1 binding protein
Synonyms: 2410018J24Rik, DEDAF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56353
Homologene: 8159
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, 4930568E07Rik, Def-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21763
Homologene: 32414
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: ARFGEP1, P200, BIG1, D730028O18Rik, D130059B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211673
Homologene: 4687
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 4932411G06Rik, 1700021E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73254
Homologene: 35455
Hyls1
Name: HYLS1, centriolar and ciliogenesis associated
Synonyms: hydrolethalus syndrome 1, 3010015K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76832
Homologene: 82283
Syngap1
Name: synaptic Ras GTPase activating protein 1 homolog (rat)
Synonyms: Syngap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240057
Homologene: 84739
Cndp1
Name: carnosine dipeptidase 1 (metallopeptidase M20 family)
Synonyms: Cn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 338403
Homologene: 57178
Htt
Name: huntingtin
Synonyms: htt, HD, C430023I11Rik, Hdh, huntingtin, IT15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Casp2
Name: caspase 2
Synonyms: Caspase-2, Nedd2, Ich-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12366
HGNC: HGNC:1503
Homologene: 7254
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, p2, p3, p4, RRP6, PM-Scl, Pmscl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Smurf2
Name: SMAD specific E3 ubiquitin protein ligase 2
Synonyms: 2810411E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66313
Homologene: 41490
AU041133
Name: expressed sequence AU041133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216177
Homologene: 87560
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, E530005C20Rik, LOC224126, Hapip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Slc44a3
Name: solute carrier family 44, member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213603
Homologene: 64830
Slitrk1
Name: SLIT and NTRK-like family, member 1
Synonyms: 3200001I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76965
VEGA: 14
Homologene: 14174
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alpha cardiac MHC, alphaMHC, alpha myosin, Myhca, cardiomyopathy, hypertrophic 1, Myhc-a, alpha-MHC, A830009F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Kif27
Name: kinesin family member 27
Synonyms: 4930517I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75050
VEGA: 13
Homologene: 69235
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Ceacam18
Name: carcinoembryonic antigen-related cell adhesion molecule 18
Synonyms: 2010110O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72431
Homologene: 48111
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, 9430076A06Rik, D430038H04Rik, LOC382129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Rab44
Name: RAB44, member RAS oncogene family
Synonyms: 9830134C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 442827
Homologene: 53300
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Asb8
Name: ankyrin repeat and SOCS box-containing 8
Synonyms: 4930539L19Rik, C430011H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78541
Homologene: 32572
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Capn12
Name: calpain 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60594
Homologene: 77333
Olfr800
Name: olfactory receptor 800
Synonyms: MOR114-7, GA_x6K02T2PULF-11338429-11339364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258541
Homologene: 27203
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Tm7sf2
Name: transmembrane 7 superfamily member 2
Synonyms: ANG1, 3110041O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73166
Homologene: 68305
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Duox1
Name: dual oxidase 1
Synonyms: NOXEF1, LNOX1, THOX1, 9930101G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Tdrd12
Name: tudor domain containing 12
Synonyms: repro23, G1-476-14, 2410070K17Rik, EG434165, 2410004F06Rik, ecat8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71981
Homologene: 87053
Mep1a
Name: meprin 1 alpha
Synonyms: Mep-1a, meprin A alpha-subunit, meprin alpha, Mep1, Mep-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17287
HGNC: HGNC:7015
Homologene: 31323
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: B430315C20Rik, Hisppd2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 327655
Homologene: 49395
Vmn1r68
Name: vomeronasal 1 receptor 68
Synonyms: Gm6898
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628580
Homologene: 120153
Ablim3
Name: actin binding LIM protein family, member 3
Synonyms: D930036B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319713
VEGA: 18
Homologene: 69175
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: MDC-L, C130072N01Rik, D430033C21Rik, Dtgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Bmp2k
Name: BMP2 inducible kinase
Synonyms: 4933417M22Rik, BIKE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140780
Homologene: 34134
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269437
Homologene: 88833
4930505A04Rik
Name: RIKEN cDNA 4930505A04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75087
Homologene: 18988
Habp2
Name: hyaluronic acid binding protein 2
Synonyms: FSAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226243
HGNC: HGNC:4798
Homologene: 3050
Ccdc92b
Name: coiled-coil domain containing 92B
Synonyms: E130309D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432582
Homologene: 134144
Cd209c
Name: CD209c antigen
Synonyms: SIGNR2, mSIGNR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170776
HGNC: HGNC:1641
Homologene: 87186
Herpud1
Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms: Herp, Mifl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 64209
Homologene: 40973
Cyb5d2
Name: cytochrome b5 domain containing 2
Synonyms: neuferricin, 9330151E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192986
Homologene: 14701
Trbv12-2
Name: T cell receptor beta, variable 12-2
Synonyms: Tcrb-V5.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100124674
Igkv18-36
Name: immunoglobulin kappa chain variable 18-36
Synonyms: Gm16689
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 620088
1110037F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Aim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 10,160,739 bp
  • T to C, chromosome 1 at 20,201,083 bp
  • T to A, chromosome 2 at 32,206,473 bp
  • A to G, chromosome 2 at 102,777,450 bp
  • A to G, chromosome 2 at 121,337,899 bp
  • T to G, chromosome 2 at 122,327,860 bp
  • T to C, chromosome 3 at 63,697,522 bp
  • T to G, chromosome 3 at 121,527,200 bp
  • T to A, chromosome 4 at 11,514,036 bp
  • A to G, chromosome 4 at 148,565,387 bp
  • A to G, chromosome 5 at 34,813,190 bp
  • T to G, chromosome 5 at 97,056,982 bp
  • T to C, chromosome 5 at 108,140,874 bp
  • C to A, chromosome 5 at 137,456,655 bp
  • G to A, chromosome 6 at 41,118,840 bp
  • C to A, chromosome 6 at 42,267,586 bp
  • A to G, chromosome 6 at 69,992,528 bp
  • A to G, chromosome 6 at 100,233,190 bp
  • A to G, chromosome 6 at 121,639,336 bp
  • A to G, chromosome 7 at 10,527,820 bp
  • C to A, chromosome 7 at 28,881,958 bp
  • T to C, chromosome 7 at 35,529,264 bp
  • A to T, chromosome 7 at 43,636,958 bp
  • C to A, chromosome 8 at 3,945,699 bp
  • A to G, chromosome 8 at 23,446,244 bp
  • T to C, chromosome 8 at 94,392,239 bp
  • A to T, chromosome 9 at 16,375,833 bp
  • G to A, chromosome 9 at 35,561,184 bp
  • T to A, chromosome 10 at 43,975,133 bp
  • T to A, chromosome 10 at 82,151,212 bp
  • A to G, chromosome 10 at 129,659,934 bp
  • C to T, chromosome 11 at 30,426,349 bp
  • T to C, chromosome 11 at 59,002,081 bp
  • C to T, chromosome 11 at 59,042,127 bp
  • A to T, chromosome 11 at 72,789,210 bp
  • A to G, chromosome 11 at 74,638,012 bp
  • C to T, chromosome 11 at 106,519,913 bp
  • A to T, chromosome 11 at 106,836,148 bp
  • T to C, chromosome 12 at 112,775,796 bp
  • A to G, chromosome 13 at 58,313,146 bp
  • T to C, chromosome 14 at 54,950,407 bp
  • A to G, chromosome 14 at 68,655,681 bp
  • A to G, chromosome 14 at 108,911,572 bp
  • A to T, chromosome 15 at 98,136,382 bp
  • T to G, chromosome 16 at 33,987,091 bp
  • A to T, chromosome 17 at 26,958,218 bp
  • A to T, chromosome 17 at 29,148,238 bp
  • G to A, chromosome 17 at 43,478,164 bp
  • T to C, chromosome 18 at 61,823,922 bp
  • C to A, chromosome 18 at 84,612,833 bp
  • T to A, chromosome 19 at 4,738,219 bp
  • A to G, chromosome 19 at 6,063,884 bp
  • T to A, chromosome 19 at 56,306,786 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5835 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044056-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.