Strain Name:
C57BL/6J-MtgxR5841Btlr
Stock Number:
044061-MU
Citation ID:
RRID:MMRRC_044061-MU
Other Names:
R5841 (G1)
Major Collection:

Gene Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Rgs8
Name: regulator of G-protein signaling 8
Synonyms: 6530413N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67792
Homologene: 23152
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Zmym6
Name: zinc finger, MYM-type 6
Synonyms: 9330177P20Rik, D4Wsu24e, Zfp258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100177
Homologene: 5186
Cdyl
Name: chromodomain protein, Y chromosome-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12593
VEGA: 13
HGNC: HGNC:1811
Homologene: 3548
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75786
Homologene: 8844
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: RPC1, 9330175N20Rik, RPC155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Cenpf
Name: centromere protein F
Synonyms: mitosin, Lek1, 6530404A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Ptbp1
Name: polypyrimidine tract binding protein 1
Synonyms: hnRNP I, Ptb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19205
HGNC: HGNC:9583
Homologene: 49188
Kcnn2
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms: bc, fri, SK2, small conductance calcium-activated potassium channel 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 140492
HGNC: HGNC:6291
Homologene: 135651
Ino80d
Name: INO80 complex subunit D
Synonyms: A430093A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227195
Homologene: 9819
Cpsf2
Name: cleavage and polyadenylation specific factor 2
Synonyms: 100kDa, 2610024B04Rik, Cpsf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 51786
VEGA: 12
HGNC: HGNC:2325
Homologene: 6460
Sbf1
Name: SET binding factor 1
Synonyms: Mtmr5, 2610510A08Rik, B230113C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77980
Homologene: 84710
Bend5
Name: BEN domain containing 5
Synonyms: 2310026E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67621
Homologene: 41574
Mtpn
Name: myotrophin
Synonyms: V1, 5033418D15Rik, Gcdp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14489
Homologene: 40607
Srebf1
Name: sterol regulatory element binding transcription factor 1
Synonyms: ADD-1, SREBP1, bHLHd1, SREBP-1a, SREBP-1c, SREBP-1, SREBP1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20787
Homologene: 3079
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: 6530411D08Rik, Pwp2, Pwp2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Slc38a9
Name: solute carrier family 38, member 9
Synonyms: 9130023D20Rik, 9430067K09Rik, 6720411P22Rik, 4833412L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 268706
VEGA: 13
Homologene: 18139
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72205
Homologene: 8125
Brd8
Name: bromodomain containing 8
Synonyms: 2610007E11Rik, p120, SMAP, 4432404P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 78656
Homologene: 41790
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: C030002J06Rik, 4930429G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 78787
Homologene: 90902
Srp54b
Name: signal recognition particle 54B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 665155
VEGA: 12
Homologene: 2362
Mgat4c
Name: MGAT4 family, member C
Synonyms: 9130411I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67569
Homologene: 8297
Rhbdf2
Name: rhomboid 5 homolog 2
Synonyms: 4732465I17Rik, iRhom2, Rhbdl6, cub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217344
Homologene: 11612
Abcb6
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 6
Synonyms: 1200005B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74104
HGNC: HGNC:47
Homologene: 11375
Cyp7b1
Name: cytochrome P450, family 7, subfamily b, polypeptide 1
Synonyms: D3Ertd552e, hct-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13123
HGNC: HGNC:2652
Homologene: 3544
Dennd5b
Name: DENN/MADD domain containing 5B
Synonyms: D030011O10Rik, 9330160C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320560
Homologene: 44911
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hyrh, hy3, hy-3, 1700034M11Rik, 4930545D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Mycbpap
Name: MYCBP associated protein
Synonyms: 4932408B01Rik, AMAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104601
Homologene: 49982
Klb
Name: klotho beta
Synonyms: betaKlotho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83379
Homologene: 12820
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246177
Homologene: 27996
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Strc
Name: stereocilin
Synonyms: DFNB16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140476
Homologene: 15401
Kpna7
Name: karyopherin alpha 7 (importin alpha 8)
Synonyms: LOC381686, importin alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381686
Homologene: 73467
Sdr16c6
Name: short chain dehydrogenase/reductase family 16C, member 6
Synonyms: 4833413O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242286
Homologene: 135698
Gsdmc2
Name: gasdermin C2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 331063
HGNC: HGNC:7151
Homologene: 69487
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Mmp12
Name: matrix metallopeptidase 12
Synonyms: macrophage elastase, MMP12, Mmel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17381
HGNC: HGNC:7158
Homologene: 20547
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p101, Foap2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320207
Homologene: 8627
Pcnx
Name: pecanex homolog
Synonyms: 2900024E21Rik, 3526401J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, Mll4, C430014K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Cyp4a12a
Name: cytochrome P450, family 4, subfamily a, polypeptide 12a
Synonyms: Cyp4a12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277753
Homologene: 134044
Lmbrd2
Name: LMBR1 domain containing 2
Synonyms: 9930036E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320506
VEGA: 15
Homologene: 44696
Gm13088
Name: predicted gene 13088
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277668
Homologene: 129883
Edc3
Name: enhancer of mRNA decapping 3
Synonyms: Yjdc, Lsm16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 353190
Homologene: 11827
Bbs12
Name: Bardet-Biedl syndrome 12 (human)
Synonyms: LOC241950, LOC386537, LOC241950
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241950
Homologene: 17634
Myrf
Name: myelin regulatory factor
Synonyms: LOC225908, Gm98, LOC386531
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Gm15448
Name: predicted gene 15448
Synonyms: ENSMUSG00000074419
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100041146
HGNC: HGNC:6607
Homologene: 134028
Dlgap3
Name: DLG associated protein 3
Synonyms: PSD-95/SAP90-binding protein 3, DAP3, Prpl8, SAP90/PSD 95 associated protein 3, Sapap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242667
Homologene: 18276
Meis2
Name: Meis homeobox 2
Synonyms: A430109D20Rik, Meis2, Mrg1, Stra10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17536
HGNC: HGNC:7001
Homologene: 7846
Slc40a1
Name: solute carrier family 40 (iron-regulated transporter), member 1
Synonyms: Pcm, FPN1, Dusg, Slc11a3, Ol5, metal transporting protein 1, MTP1, IREG1, ferroportin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53945
Homologene: 40959
Dync2li1
Name: dynein cytoplasmic 2 light intermediate chain 1
Synonyms: LIC3, D2lic, mD2LIC, 4933404O11Rik, CGI-60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213575
VEGA: 17
Homologene: 9336
Ganc
Name: glucosidase, alpha; neutral C
Synonyms: 5830445O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76051
HGNC: HGNC:4139
Homologene: 25627
Gm11595
Name: predicted gene 11595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Ncf2
Name: neutrophil cytosolic factor 2
Synonyms: Ncf-2, p67phox, NADPH oxidase subunit (67kDa), NOXA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17970
HGNC: HGNC:7661
Homologene: 374
Slc36a3
Name: solute carrier family 36 (proton/amino acid symporter), member 3
Synonyms: TRAMD2, PAT3, tramdorin2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 215332
Homologene: 76175
Olfr585
Name: olfactory receptor 585
Synonyms: GA_x6K02T2PBJ9-5809085-5810035, MOR14-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259091
Homologene: 133721
Vmn1r11
Name: vomeronasal 1 receptor 11
Synonyms: V1rc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113860
Homologene: 128345
Mrpl24
Name: mitochondrial ribosomal protein L24
Synonyms: 6720473G22Rik, 2810470K06Rik, 2010005E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67707
Homologene: 12241
Gnptg
Name: N-acetylglucosamine-1-phosphotransferase, gamma subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 214505
VEGA: 17
Homologene: 13047
Abhd6
Name: abhydrolase domain containing 6
Synonyms: 0610041D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66082
VEGA: 14
Homologene: 23246
Slc9a3r2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
Synonyms: E3karp, Octs2, 0610011L07Rik, Sryip1, Sip1, 1200011K07Rik, Nherf2, 2010007A20Rik, Sip-1, Tka-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 65962
VEGA: 17
Homologene: 56962
Susd3
Name: sushi domain containing 3
Synonyms: 1700017I11Rik, 2810440J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66329
Homologene: 11948
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 45,912,349 bp
  • A to G, chromosome 1 at 63,058,840 bp
  • A to T, chromosome 1 at 75,174,350 bp
  • A to T, chromosome 1 at 152,821,518 bp
  • A to G, chromosome 1 at 153,692,828 bp
  • G to T, chromosome 1 at 189,657,444 bp
  • T to A, chromosome 2 at 69,480,153 bp
  • T to A, chromosome 2 at 91,600,682 bp
  • T to A, chromosome 2 at 116,058,664 bp
  • C to T, chromosome 2 at 120,411,539 bp
  • A to G, chromosome 2 at 121,365,877 bp
  • A to T, chromosome 3 at 18,097,506 bp
  • T to G, chromosome 3 at 37,319,521 bp
  • G to A, chromosome 3 at 87,922,985 bp
  • C to T, chromosome 4 at 4,062,728 bp
  • A to G, chromosome 4 at 111,433,470 bp
  • A to T, chromosome 4 at 115,326,702 bp
  • A to G, chromosome 4 at 127,100,670 bp
  • A to G, chromosome 4 at 127,195,400 bp
  • A to G, chromosome 4 at 143,655,539 bp
  • A to T, chromosome 5 at 65,379,324 bp
  • T to C, chromosome 5 at 144,993,956 bp
  • T to C, chromosome 6 at 14,718,984 bp
  • C to T, chromosome 6 at 35,512,290 bp
  • T to A, chromosome 6 at 57,137,802 bp
  • T to C, chromosome 6 at 149,044,755 bp
  • T to A, chromosome 7 at 3,822,899 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to C, chromosome 7 at 103,097,954 bp
  • TTCCTC to TTC, chromosome 7 at 119,951,021 bp
  • T to C, chromosome 8 at 110,533,214 bp
  • G to A, chromosome 9 at 7,347,501 bp
  • T to C, chromosome 9 at 57,744,602 bp
  • A to G, chromosome 10 at 78,172,118 bp
  • A to G, chromosome 10 at 79,859,932 bp
  • A to T, chromosome 10 at 102,388,965 bp
  • T to A, chromosome 11 at 6,507,000 bp
  • T to C, chromosome 11 at 21,998,594 bp
  • A to T, chromosome 11 at 55,125,721 bp
  • T to A, chromosome 11 at 60,203,584 bp
  • T to C, chromosome 11 at 68,492,270 bp
  • T to A, chromosome 11 at 94,505,610 bp
  • C to A, chromosome 11 at 99,772,317 bp
  • G to A, chromosome 11 at 116,602,354 bp
  • A to G, chromosome 12 at 55,252,829 bp
  • T to A, chromosome 12 at 81,918,655 bp
  • T to C, chromosome 12 at 101,985,238 bp
  • T to C, chromosome 13 at 35,872,561 bp
  • C to A, chromosome 13 at 49,238,726 bp
  • T to C, chromosome 13 at 112,695,322 bp
  • T to A, chromosome 14 at 8,049,596 bp
  • G to A, chromosome 14 at 20,550,283 bp
  • A to T, chromosome 14 at 24,450,698 bp
  • C to T, chromosome 14 at 78,994,518 bp
  • A to G, chromosome 15 at 9,182,570 bp
  • C to T, chromosome 15 at 63,826,210 bp
  • T to C, chromosome 15 at 89,308,068 bp
  • G to A, chromosome 15 at 98,852,109 bp
  • A to G, chromosome 17 at 24,496,209 bp
  • A to T, chromosome 17 at 24,644,877 bp
  • A to G, chromosome 17 at 25,235,417 bp
  • G to A, chromosome 17 at 84,633,562 bp
  • A to G, chromosome 18 at 34,605,523 bp
  • G to A, chromosome 18 at 45,559,396 bp
  • T to C, chromosome 19 at 10,223,547 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5841 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044061-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.