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Strain Name:
C57BL/6J-MtgxR5853Btlr/Mmmh
Stock Number:
044068-MU
Citation ID:
RRID:MMRRC_044068-MU
Other Names:
R5853 (G1)
Major Collection:

Strain Information

Atf2
Name: activating transcription factor 2
Synonyms: mXBP, CRE-BP, Creb2, D130078H02Rik, ATF-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11909
HGNC: HGNC:784
Homologene: 31061
Ndufv1
Name: NADH:ubiquinone oxidoreductase core subunit V1
Synonyms: 24 kDa (FP)
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17995
HGNC: HGNC:7716
Homologene: 5151
Slc25a33
Name: solute carrier family 25, member 33
Synonyms: 5730438N18Rik, Pnc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70556
Homologene: 57076
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235469
Homologene: 17151
Rp9
Name: retinitis pigmentosa 9 (human)
Synonyms: PAP-1, Rp9h
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 55934
VEGA: 9
Homologene: 10290
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 16,665,332 bp
  • T to A, chromosome 1 at 38,037,307 bp
  • T to C, chromosome 1 at 92,491,717 bp
  • T to A, chromosome 1 at 130,846,604 bp
  • C to A, chromosome 1 at 173,862,504 bp
  • T to A, chromosome 2 at 30,137,381 bp
  • T to C, chromosome 2 at 38,369,041 bp
  • T to A, chromosome 2 at 40,663,726 bp
  • T to C, chromosome 2 at 73,828,469 bp
  • C to G, chromosome 2 at 152,628,280 bp
  • A to T, chromosome 2 at 164,049,518 bp
  • A to T, chromosome 3 at 55,992,401 bp
  • G to T, chromosome 3 at 122,103,531 bp
  • A to C, chromosome 4 at 53,528,682 bp
  • A to G, chromosome 4 at 116,163,305 bp
  • A to G, chromosome 4 at 143,896,920 bp
  • A to T, chromosome 4 at 149,753,892 bp
  • T to C, chromosome 5 at 24,592,192 bp
  • G to A, chromosome 5 at 30,918,622 bp
  • T to C, chromosome 6 at 24,491,602 bp
  • T to C, chromosome 6 at 90,346,756 bp
  • C to T, chromosome 7 at 25,225,176 bp
  • A to C, chromosome 7 at 98,888,077 bp
  • A to G, chromosome 7 at 119,938,833 bp
  • G to A, chromosome 7 at 120,340,583 bp
  • G to T, chromosome 7 at 127,033,367 bp
  • T to C, chromosome 8 at 3,926,549 bp
  • T to C, chromosome 8 at 71,655,129 bp
  • T to C, chromosome 9 at 21,593,453 bp
  • G to A, chromosome 9 at 22,448,769 bp
  • G to A, chromosome 9 at 36,713,687 bp
  • A to T, chromosome 9 at 49,418,695 bp
  • C to T, chromosome 9 at 72,330,942 bp
  • T to A, chromosome 9 at 108,533,608 bp
  • T to C, chromosome 10 at 7,142,977 bp
  • T to A, chromosome 11 at 30,791,234 bp
  • T to C, chromosome 12 at 56,335,877 bp
  • C to A, chromosome 12 at 104,783,902 bp
  • G to T, chromosome 13 at 20,999,902 bp
  • T to G, chromosome 13 at 23,011,514 bp
  • A to G, chromosome 13 at 40,206,717 bp
  • G to A, chromosome 13 at 96,946,652 bp
  • T to C, chromosome 13 at 112,481,537 bp
  • A to T, chromosome 14 at 50,186,869 bp
  • A to G, chromosome 15 at 77,714,467 bp
  • T to C, chromosome 16 at 58,675,417 bp
  • C to T, chromosome 17 at 23,972,846 bp
  • G to A, chromosome 17 at 32,056,684 bp
  • T to C, chromosome 17 at 50,047,326 bp
  • A to G, chromosome 17 at 85,032,580 bp
  • A to G, chromosome 18 at 68,339,493 bp
  • A to T, chromosome 19 at 4,008,811 bp
  • A to G, chromosome 19 at 33,782,230 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5853 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044068-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.