Strain Name:
C57BL/6J-MtgxR5853Btlr/Mmmh
Stock Number:
044068-MU
Citation ID:
RRID:MMRRC_044068-MU
Other Names:
R5853 (G1)
Major Collection:

Gene Information

Atf2
Name: activating transcription factor 2
Synonyms: mXBP, CRE-BP, Creb2, D130078H02Rik, ATF-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11909
HGNC: HGNC:784
Homologene: 31061
Ndufv1
Name: NADH:ubiquinone oxidoreductase core subunit V1
Synonyms: 24 kDa (FP)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17995
HGNC: HGNC:7716
Homologene: 5151
Slc25a33
Name: solute carrier family 25, member 33
Synonyms: 5730438N18Rik, Pnc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70556
Homologene: 57076
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103554
Homologene: 113742
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235469
Homologene: 17151
Rp9
Name: retinitis pigmentosa 9 (human)
Synonyms: PAP-1, Rp9h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 55934
VEGA: 9
Homologene: 10290
Uvrag
Name: UV radiation resistance associated gene
Synonyms: 9530039D02Rik, Uvragl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78610
Homologene: 31150
Qrich1
Name: glutamine-rich 1
Synonyms: 2610028H07Rik, b2b2404Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69232
Homologene: 9803
Slc44a1
Name: solute carrier family 44, member 1
Synonyms: CHTL1, CTL1, 4833416H08Rik, Cdw92, 2210409B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100434
Homologene: 11137
Chek1
Name: checkpoint kinase 1
Synonyms: Chk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12649
HGNC: HGNC:1925
Homologene: 975
Mc5r
Name: melanocortin 5 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17203
VEGA: 18
HGNC: HGNC:6933
Homologene: 4321
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72462
Homologene: 57086
Lhx2
Name: LIM homeobox protein 2
Synonyms: Lh-2, LH2A, apterous, ap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16870
HGNC: HGNC:6594
Homologene: 55848
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Tbc1d13
Name: TBC1 domain family, member 13
Synonyms: 2600014A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70296
Homologene: 10068
Chpf2
Name: chondroitin polymerizing factor 2
Synonyms: 2010209O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100910
Homologene: 14763
Il6st
Name: interleukin 6 signal transducer
Synonyms: gp130, CD130, D13Ertd699e, 5133400A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16195
HGNC: HGNC:6021
Homologene: 1645
Kif22
Name: kinesin family member 22
Synonyms: Kif22a, Kid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 110033
HGNC: HGNC:6391
Homologene: 32011
Mbip
Name: MAP3K12 binding inhibitory protein 1
Synonyms: 4933408E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217588
VEGA: 12
Homologene: 9576
Clmn
Name: calmin
Synonyms: 9330188N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94040
VEGA: 12
Homologene: 11683
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: IF2, A030003E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226982
Homologene: 134613
Cd209b
Name: CD209b antigen
Synonyms: SIGNR1, mSIGNR1, 1810030I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69165
HGNC: HGNC:1641
Homologene: 84858
Abca4
Name: ATP-binding cassette, sub-family A (ABC1), member 4
Synonyms: Rim protein, RmP, Abc10, D430003I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Vmn1r213
Name: vomeronasal 1 receptor 213
Synonyms: V1rh6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171249
Homologene: 110880
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Abca15
Name: ATP-binding cassette, sub-family A (ABC1), member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320631
Homologene: 87255
Slc3a1
Name: solute carrier family 3, member 1
Synonyms: NTAA, D2H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20532
VEGA: 17
Homologene: 37289
Uroc1
Name: urocanase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243537
Homologene: 76629
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382018
Homologene: 11279
Mndal
Name: myeloid nuclear differentiation antigen like
Synonyms: Ifi212
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040462
HGNC: HGNC:5395
Homologene: 115929
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Lipo3
Name: lipase, member O3
Synonyms: Lipo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381236
Homologene: 103863
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, gp115, EMILIN-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100952
Homologene: 5117
Aoah
Name: acyloxyacyl hydrolase
Synonyms: 4930433E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 27052
VEGA: 13
HGNC: HGNC:548
Homologene: 1238
Olfr730
Name: olfactory receptor 730
Synonyms: GA_x6K02T2PMLR-5881670-5880717, MOR247-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258486
Homologene: 17269
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: 4932408B21Rik, Trs4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214704
Homologene: 44790
Ankk1
Name: ankyrin repeat and kinase domain containing 1
Synonyms: 9930020N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244859
VEGA: 9
Homologene: 18258
Gcnt4
Name: glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
Synonyms: LOC218476, LOC238786, C2GNT3, Gm73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218476
VEGA: 13
Homologene: 41144
Pabpc1l
Name: poly(A) binding protein, cytoplasmic 1-like
Synonyms: ePAB, 1810053B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381404
Homologene: 77989
Cpox
Name: coproporphyrinogen oxidase
Synonyms: clone 560, cac, Cpo, nct
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12892
VEGA: 16
HGNC: HGNC:2321
Homologene: 76
Zfp526
Name: zinc finger protein 526
Synonyms: D030024H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210172
Homologene: 18447
Pramel11
Name: PRAME like 11
Synonyms: Gm13099, Pramef6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 195555
Homologene: 133722
Olfr1415
Name: olfactory receptor 1415
Synonyms: GA_x6K02T2R7CC-81266841-81267776, MOR103-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258228
Homologene: 79367
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76438
Homologene: 18745
Cnksr3
Name: Cnksr family member 3
Synonyms: Magi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215748
Homologene: 18192
Apol7e
Name: apolipoprotein L 7e
Synonyms: ENSMUSG00000071716
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666348
VEGA: 15
Homologene: 40940
Rem1
Name: rad and gem related GTP binding protein 1
Synonyms: E030011C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19700
Homologene: 7514
Prss30
Name: protease, serine 30
Synonyms: 2010015P21Rik, Disp, Disp1, Tmprss8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 30943
Homologene: 88826
Tspan1
Name: tetraspanin 1
Synonyms: 9030418M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66805
Homologene: 21170
Tmem70
Name: transmembrane protein 70
Synonyms: 2210416J16Rik, 1110020A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70397
Homologene: 9890
1810026J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 16,665,332 bp
  • T to A, chromosome 1 at 38,037,307 bp
  • T to C, chromosome 1 at 92,491,717 bp
  • T to A, chromosome 1 at 130,846,604 bp
  • C to A, chromosome 1 at 173,862,504 bp
  • T to A, chromosome 2 at 30,137,381 bp
  • T to C, chromosome 2 at 38,369,041 bp
  • T to A, chromosome 2 at 40,663,726 bp
  • T to C, chromosome 2 at 73,828,469 bp
  • C to G, chromosome 2 at 152,628,280 bp
  • A to T, chromosome 2 at 164,049,518 bp
  • A to T, chromosome 3 at 55,992,401 bp
  • G to T, chromosome 3 at 122,103,531 bp
  • A to C, chromosome 4 at 53,528,682 bp
  • A to G, chromosome 4 at 116,163,305 bp
  • A to G, chromosome 4 at 143,896,920 bp
  • A to T, chromosome 4 at 149,753,892 bp
  • T to C, chromosome 5 at 24,592,192 bp
  • G to A, chromosome 5 at 30,918,622 bp
  • T to C, chromosome 6 at 24,491,602 bp
  • T to C, chromosome 6 at 90,346,756 bp
  • C to T, chromosome 7 at 25,225,176 bp
  • A to C, chromosome 7 at 98,888,077 bp
  • A to G, chromosome 7 at 119,938,833 bp
  • G to A, chromosome 7 at 120,340,583 bp
  • G to T, chromosome 7 at 127,033,367 bp
  • T to C, chromosome 8 at 3,926,549 bp
  • T to C, chromosome 8 at 71,655,129 bp
  • T to C, chromosome 9 at 21,593,453 bp
  • G to A, chromosome 9 at 22,448,769 bp
  • G to A, chromosome 9 at 36,713,687 bp
  • A to T, chromosome 9 at 49,418,695 bp
  • C to T, chromosome 9 at 72,330,942 bp
  • T to A, chromosome 9 at 108,533,608 bp
  • T to C, chromosome 10 at 7,142,977 bp
  • T to A, chromosome 11 at 30,791,234 bp
  • T to C, chromosome 12 at 56,335,877 bp
  • C to A, chromosome 12 at 104,783,902 bp
  • G to T, chromosome 13 at 20,999,902 bp
  • T to G, chromosome 13 at 23,011,514 bp
  • A to G, chromosome 13 at 40,206,717 bp
  • G to A, chromosome 13 at 96,946,652 bp
  • T to C, chromosome 13 at 112,481,537 bp
  • A to T, chromosome 14 at 50,186,869 bp
  • A to G, chromosome 15 at 77,714,467 bp
  • T to C, chromosome 16 at 58,675,417 bp
  • C to T, chromosome 17 at 23,972,846 bp
  • G to A, chromosome 17 at 32,056,684 bp
  • T to C, chromosome 17 at 50,047,326 bp
  • A to G, chromosome 17 at 85,032,580 bp
  • A to G, chromosome 18 at 68,339,493 bp
  • A to T, chromosome 19 at 4,008,811 bp
  • A to G, chromosome 19 at 33,782,230 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5853 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044068-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.