Strain Name:
C57BL/6J-MtgxR5857Btlr
Stock Number:
044069-MU
Citation ID:
RRID:MMRRC_044069-MU
Other Names:
R5857 (G1)
Major Collection:

Gene Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: ROSA62, Spnb4, nmf261, 1700022P15Rik, dyn, 5830426A08Rik, SpbIV, neuroaxonal dystrophy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80297
Homologene: 11879
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101772
Homologene: 75079
Lmna
Name: lamin A
Synonyms: lamin A/C, Dhe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16905
HGNC: HGNC:6636
Homologene: 41321
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Gk5
Name: glycerol kinase 5 (putative)
Synonyms: G630067D24Rik, C330018K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235533
Homologene: 15141
Atad5
Name: ATPase family, AAA domain containing 5
Synonyms: LOC237877, C130052G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237877
Homologene: 32611
Ctnnbl1
Name: catenin, beta like 1
Synonyms: 5730471K09Rik, FLJ21108, NYD-SP19, P14L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66642
Homologene: 12003
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Crhbp
Name: corticotropin releasing hormone binding protein
Synonyms: CRH-BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12919
VEGA: 13
HGNC: HGNC:2356
Homologene: 1418
Niban2
Name: niban apoptosis regulator 2
Synonyms: 9130404D14Rik, Fam129b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227737
Homologene: 11269
Vps18
Name: VPS18 CORVET/HOPS core subunit
Synonyms: 9930024E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228545
Homologene: 13302
Npnt
Name: nephronectin
Synonyms: 1110009H02Rik, POEM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 114249
Homologene: 14138
Scube1
Name: signal peptide, CUB domain, EGF-like 1
Synonyms: A630023E24Rik, 7330410C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64706
Homologene: 11224
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11858
Homologene: 21123
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 58996
Homologene: 104145
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Rad52
Name: RAD52 homolog, DNA repair protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19365
HGNC: HGNC:9824
Homologene: 31118
Rbm19
Name: RNA binding motif protein 19
Synonyms: 1200009A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74111
Homologene: 7158
Ube2d2a
Name: ubiquitin-conjugating enzyme E2D 2A
Synonyms: ubc4, 1500034D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 56550
VEGA: 18
Homologene: 2506
Efl1
Name: elongation factor like GTPase 1
Synonyms: D7Ertd791e, 4932434J20Rik, 6030468D11Rik, Eftud1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101592
Homologene: 11599
Tsc2
Name: TSC complex subunit 2
Synonyms: Nafld, tuberin, tuberous sclerosis 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Ism2
Name: isthmin 2
Synonyms: Thsd3, LOC217738
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217738
Homologene: 83509
Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Synonyms: aldosterone receptor, Mlr, mineralocorticoid receptor, MR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 110784
HGNC: HGNC:7979
Homologene: 121495
Ccdc38
Name: coiled-coil domain containing 38
Synonyms: 4933417K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237465
Homologene: 52182
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Olfr884
Name: olfactory receptor 884
Synonyms: MOR162-11P, MOR162-9P, MOR162-13, GA_x6K02T2PVTD-31726544-31727473, Olfr1550-ps1, MOR162-11P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257996
Homologene: 79400
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Igkv8-18
Name: immunoglobulin kappa variable 8-18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 667859
Col4a2
Name: collagen, type IV, alpha 2
Synonyms: Col4a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12827
HGNC: HGNC:2203
Homologene: 1390
Olfr870
Name: olfactory receptor 870
Synonyms: MOR141-1, GA_x6K02T2PVTD-13912679-13911744
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57251
Homologene: 138319
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384752
Disp3
Name: dispatched RND transporter family member 3
Synonyms: Ptchd2, G630052C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242748
Homologene: 25712
Hoxa9
Name: homeobox A9
Synonyms: D6a9, Hox-1.7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15405
HGNC: HGNC:5109
Homologene: 7766
Pabpc1l
Name: poly(A) binding protein, cytoplasmic 1-like
Synonyms: 1810053B01Rik, ePAB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381404
Homologene: 77989
Olfr248
Name: olfactory receptor 248
Synonyms: MOR267-7, GA_x6K02T2P20D-20771141-20770212, Olfr415, GA_x6K02T2MFC0-1145-1312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258709
1700030K09Rik
Name: RIKEN cDNA 1700030K09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72254
Homologene: 12975
Cyp4f16
Name: cytochrome P450, family 4, subfamily f, polypeptide 16
Synonyms: 2310021J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70101
Homologene: 135840
Dlgap1
Name: DLG associated protein 1
Synonyms: Sapap1, Gkap, D17Bwg0511e, 4933422O14Rik, GKAP/SAPAP, SAPAP1, DAP-1 beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
Togaram1
Name: TOG array regulator of axonemal microtubules 1
Synonyms: Fam179b, A430041B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 328108
VEGA: 12
Homologene: 15025
Lrfn3
Name: leucine rich repeat and fibronectin type III domain containing 3
Synonyms: A530045B06Rik, SALM4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233067
Homologene: 11558
Anks6
Name: ankyrin repeat and sterile alpha motif domain containing 6
Synonyms: SamCystin, b2b1801.1Clo, 2210417J20Rik, LOC269533, Samd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75691
Homologene: 19545
Cep112
Name: centrosomal protein 112
Synonyms: Ccdc46, 1700029K01Rik, 1700001M19Rik, Macoco, 8430407H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76380
Homologene: 44915
Prl7a1
Name: prolactin family 7, subfamily a, member 1
Synonyms: Prlpe, Prlpg, PLP-G, PLP-E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19113
Homologene: 136279
Krtap6-2
Name: keratin associated protein 6-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16701
Btbd8
Name: BTB (POZ) domain containing 8
Synonyms: Gm16115, A830010M20Rik, EG627196
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100503185
VEGA: 5
Homologene: 82388
Nat8f3
Name: N-acetyltransferase 8 (GCN5-related) family member 3
Synonyms: 4930583K21Rik, Cml3, 4833414A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93674
Homologene: 76450
Gpr135
Name: G protein-coupled receptor 135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238252
VEGA: 12
Homologene: 11211
Gatb
Name: glutamyl-tRNA(Gln) amidotransferase, subunit B
Synonyms: Pet112, 9430026F02Rik, Pet112l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229487
HGNC: HGNC:8849
Homologene: 3357
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100534287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 174,391,108 bp
  • T to A, chromosome 2 at 32,909,908 bp
  • T to C, chromosome 2 at 119,297,533 bp
  • T to C, chromosome 2 at 157,789,098 bp
  • T to A, chromosome 2 at 164,044,255 bp
  • T to G, chromosome 3 at 83,270,313 bp
  • T to C, chromosome 3 at 85,575,932 bp
  • GCTGCCCACAC to GC, chromosome 3 at 88,482,531 bp
  • A to T, chromosome 3 at 132,908,349 bp
  • C to A, chromosome 4 at 32,670,646 bp
  • C to T, chromosome 4 at 47,039,736 bp
  • A to T, chromosome 4 at 148,249,183 bp
  • T to A, chromosome 5 at 96,828,792 bp
  • T to A, chromosome 5 at 107,461,532 bp
  • T to A, chromosome 5 at 120,132,942 bp
  • T to A, chromosome 6 at 52,224,297 bp
  • T to C, chromosome 6 at 70,355,920 bp
  • T to C, chromosome 6 at 85,761,753 bp
  • T to G, chromosome 6 at 119,911,007 bp
  • C to A, chromosome 7 at 10,382,377 bp
  • G to T, chromosome 7 at 27,418,713 bp
  • A to T, chromosome 7 at 30,359,438 bp
  • T to A, chromosome 7 at 82,763,189 bp
  • TTCCTC to TTC, chromosome 7 at 119,951,021 bp
  • A to T, chromosome 7 at 144,637,103 bp
  • G to A, chromosome 8 at 11,425,442 bp
  • A to G, chromosome 8 at 72,449,525 bp
  • A to G, chromosome 8 at 76,908,867 bp
  • C to T, chromosome 9 at 20,171,239 bp
  • T to G, chromosome 9 at 38,047,753 bp
  • C to A, chromosome 9 at 96,119,455 bp
  • G to T, chromosome 10 at 93,562,833 bp
  • T to C, chromosome 11 at 80,131,329 bp
  • C to T, chromosome 11 at 97,451,579 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • T to C, chromosome 11 at 108,531,471 bp
  • T to A, chromosome 11 at 115,850,281 bp
  • T to C, chromosome 12 at 8,015,397 bp
  • T to A, chromosome 12 at 64,995,557 bp
  • G to A, chromosome 12 at 72,070,840 bp
  • T to C, chromosome 12 at 87,280,061 bp
  • A to T, chromosome 13 at 27,640,701 bp
  • T to A, chromosome 13 at 95,442,232 bp
  • G to T, chromosome 15 at 83,607,260 bp
  • A to G, chromosome 16 at 17,358,984 bp
  • A to T, chromosome 16 at 89,419,642 bp
  • T to C, chromosome 17 at 24,600,007 bp
  • T to A, chromosome 17 at 32,537,024 bp
  • T to A, chromosome 17 at 67,807,843 bp
  • A to G, chromosome 17 at 70,815,393 bp
  • A to G, chromosome 18 at 35,805,543 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5857 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044069-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.