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Strain Name:
C57BL/6J-MtgxR5874Btlr/Mmmh
Stock Number:
044081-MU
Citation ID:
RRID:MMRRC_044081-MU
Other Names:
R5874 (G1)
Major Collection:

Strain Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Synonyms: alpha-CaMKII
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12322
HGNC: HGNC:1460
Homologene: 56577
Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Ddx10
Name: DEAD box helicase 10
Synonyms: 4632415A01Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77591
VEGA: 9
HGNC: HGNC:2735
Homologene: 20922
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,179,589 bp
  • C to T, chromosome 1 at 46,191,725 bp
  • A to C, chromosome 1 at 87,148,009 bp
  • T to C, chromosome 1 at 91,156,840 bp
  • A to G, chromosome 1 at 93,265,345 bp
  • G to A, chromosome 2 at 25,011,649 bp
  • G to A, chromosome 2 at 25,194,835 bp
  • T to C, chromosome 2 at 30,257,136 bp
  • T to A, chromosome 2 at 76,950,092 bp
  • A to T, chromosome 2 at 86,978,442 bp
  • T to A, chromosome 2 at 126,158,439 bp
  • C to T, chromosome 2 at 150,786,878 bp
  • A to G, chromosome 2 at 164,820,112 bp
  • C to G, chromosome 3 at 53,537,489 bp
  • A to T, chromosome 3 at 123,561,907 bp
  • A to G, chromosome 4 at 141,695,469 bp
  • A to G, chromosome 5 at 36,229,211 bp
  • C to T, chromosome 5 at 37,417,539 bp
  • C to T, chromosome 5 at 52,582,614 bp
  • A to G, chromosome 5 at 64,349,930 bp
  • T to C, chromosome 5 at 90,268,797 bp
  • T to C, chromosome 5 at 118,259,439 bp
  • T to A, chromosome 5 at 120,877,018 bp
  • T to C, chromosome 5 at 124,469,813 bp
  • A to G, chromosome 5 at 128,601,300 bp
  • A to G, chromosome 6 at 29,372,618 bp
  • A to T, chromosome 6 at 67,431,645 bp
  • T to C, chromosome 6 at 76,902,430 bp
  • A to T, chromosome 6 at 141,972,235 bp
  • A to G, chromosome 7 at 12,416,174 bp
  • T to C, chromosome 7 at 19,092,082 bp
  • G to A, chromosome 7 at 29,581,185 bp
  • T to A, chromosome 7 at 33,737,405 bp
  • G to T, chromosome 7 at 42,662,888 bp
  • A to G, chromosome 7 at 45,327,749 bp
  • T to A, chromosome 7 at 99,667,094 bp
  • T to A, chromosome 7 at 107,845,170 bp
  • T to A, chromosome 8 at 84,258,548 bp
  • A to T, chromosome 9 at 51,290,372 bp
  • A to C, chromosome 9 at 53,229,198 bp
  • T to C, chromosome 9 at 115,226,760 bp
  • T to A, chromosome 10 at 24,182,761 bp
  • C to T, chromosome 10 at 72,656,462 bp
  • T to A, chromosome 10 at 79,017,357 bp
  • A to G, chromosome 11 at 8,908,688 bp
  • A to G, chromosome 11 at 61,449,447 bp
  • T to A, chromosome 11 at 83,514,600 bp
  • T to A, chromosome 11 at 113,677,394 bp
  • T to C, chromosome 12 at 21,329,086 bp
  • T to C, chromosome 12 at 70,030,918 bp
  • T to C, chromosome 12 at 76,598,727 bp
  • A to G, chromosome 12 at 102,389,843 bp
  • C to A, chromosome 12 at 111,844,989 bp
  • A to G, chromosome 13 at 31,626,792 bp
  • A to G, chromosome 13 at 43,668,087 bp
  • A to T, chromosome 13 at 73,684,368 bp
  • T to C, chromosome 14 at 32,052,367 bp
  • T to C, chromosome 14 at 34,245,258 bp
  • T to A, chromosome 15 at 47,644,270 bp
  • T to A, chromosome 15 at 53,101,752 bp
  • T to A, chromosome 15 at 82,619,042 bp
  • C to T, chromosome 16 at 14,507,173 bp
  • T to C, chromosome 16 at 45,801,625 bp
  • C to A, chromosome 17 at 6,043,913 bp
  • T to A, chromosome 17 at 59,010,284 bp
  • T to C, chromosome 18 at 14,804,554 bp
  • A to T, chromosome 18 at 36,640,269 bp
  • G to C, chromosome 18 at 60,943,200 bp
  • A to T, chromosome 18 at 62,978,020 bp
  • C to T, chromosome 18 at 63,027,901 bp
  • T to C, chromosome 19 at 26,776,069 bp
  • C to A, chromosome 19 at 43,956,512 bp
  • C to T, chromosome 19 at 46,331,385 bp
  • T to C, chromosome 19 at 58,946,806 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5874 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044081-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.