Strain Name:
C57BL/6J-MtgxR5877Btlr
Stock Number:
044083-MU
Citation ID:
RRID:MMRRC_044083-MU
Other Names:
R5877 (G1)
Major Collection:

Gene Information

Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
8030462N17Rik
Name: RIKEN cDNA 8030462N17 gene
Synonyms: Ark2N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 212163
VEGA: 18
Homologene: 17035
Gapdhs
Name: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Synonyms: Gapd-s, Gapds
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14447
Homologene: 101265
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 52184
Homologene: 12011
P4htm
Name: prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms: P4h-tm, 4933406E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74443
Homologene: 41765
Hdac11
Name: histone deacetylase 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232232
Homologene: 11743
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Bchs, D5Ertd66e, Alfy, 2610509D04Rik, Ggtb3, Bwf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Zfp341
Name: zinc finger protein 341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228807
Homologene: 13127
Tut4
Name: terminal uridylyl transferase 4
Synonyms: Tent3a, Zcchc11, 6030404K05Rik, 9230115F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230594
Homologene: 35279
Elp1
Name: elongator complex protein 1
Synonyms: C78473, 3110040G09Rik, Ikbkap, IKAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Otud7b
Name: OTU domain containing 7B
Synonyms: 4930463P07Rik, 2900060B22Rik, Za20d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229603
Homologene: 10624
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, KMT2H, E430018P19Rik, 8030453L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 192195
Homologene: 10225
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Klhl12
Name: kelch-like 12
Synonyms: C3ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240756
Homologene: 23317
Casp2
Name: caspase 2
Synonyms: Ich-1, Caspase-2, Nedd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12366
HGNC: HGNC:1503
Homologene: 7254
Brca2
Name: breast cancer 2, early onset
Synonyms: Fancd1, RAB163
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Nhlrc2
Name: NHL repeat containing 2
Synonyms: 1200003G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66866
VEGA: 19
Homologene: 12048
Plekhm2
Name: pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms: 2310034J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69582
Homologene: 19575
Cd2bp2
Name: CD2 cytoplasmic tail binding protein 2
Synonyms: 2410024K20Rik, 1500011B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70233
HGNC: HGNC:1656
Homologene: 4455
Zfp398
Name: zinc finger protein 398
Synonyms: 5730513I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 272347
Homologene: 12358
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104570
Homologene: 68886
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: Vdu1, 9830169D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170822
Homologene: 8996
Camk1d
Name: calcium/calmodulin-dependent protein kinase ID
Synonyms: CaMKIdelta, E030025C11Rik, CKLiK, A630059D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227541
Homologene: 121858
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: LOC384311, mSSH-1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231637
Homologene: 41299
Slc9a4
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4
Synonyms: D730009J23Rik, NHE4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 110895
Homologene: 72232
Snx27
Name: sorting nexin family member 27
Synonyms: 5730552M22Rik, ESTM47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76742
Homologene: 12797
Zp2
Name: zona pellucida glycoprotein 2
Synonyms: Zp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22787
Homologene: 48194
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Piezo2, 9030411M15Rik, Fam38b, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: EO Myosin, MyHC-eo, extraocular myosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: 1110034K09Rik, Scn6a, Nav2.3, Nax, NaG, Nav2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20272
Homologene: 55706
Ralgps1
Name: Ral GEF with PH domain and SH3 binding motif 1
Synonyms: RALGPS1A, 5830418G11Rik, RALGEF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241308
Homologene: 65163
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: RGC2, AS250, A230067G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241694
Homologene: 28131
C3ar1
Name: complement component 3a receptor 1
Synonyms: anaphylatoxin C3a receptor, C3aR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12267
HGNC: HGNC:1319
Homologene: 2992
Fam131b
Name: family with sequence similarity 131, member B
Synonyms: 6530406I18Rik, 6330503C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76156
Homologene: 8797
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: mdg, Cav1.1, DHPR alpha1s, sj, Cchl1a3, fmd, muscle dysgenesis
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: 4631412G21Rik, PGC-1beta/ERRL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 170826
Homologene: 15776
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: 1810073P09Rik, X83337, ESTM15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75607
Homologene: 19155
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20663
Homologene: 38253
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Pxdn
Name: peroxidasin
Synonyms: 2310075M15Rik, VPO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69675
Homologene: 33907
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: SM25H2, Fbw10, SM2SH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 213980
Homologene: 32757
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229574
Homologene: 134146
Cyp2g1
Name: cytochrome P450, family 2, subfamily g, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13108
HGNC: HGNC:2633
Homologene: 75020
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, flamingo, Adgrc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Tnfrsf8
Name: tumor necrosis factor receptor superfamily, member 8
Synonyms: CD30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21941
Homologene: 949
Nxpe3
Name: neurexophilin and PC-esterase domain family, member 3
Synonyms: Fam55c, LOC385658, LOC208684
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 385658
VEGA: 16
Homologene: 17030
Alk
Name: anaplastic lymphoma kinase
Synonyms: Tcrz, CD246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11682
VEGA: 17
HGNC: HGNC:427
Homologene: 68387
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238405
Homologene: 128362
Hif3a
Name: hypoxia inducible factor 3, alpha subunit
Synonyms: bHLHe17, Nepas, MOP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53417
Homologene: 9646
Dusp22
Name: dual specificity phosphatase 22
Synonyms: 1110028K04Rik, JSP1, JKAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105352
Homologene: 86039
Plcd1
Name: phospholipase C, delta 1
Synonyms: PLC-delta 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18799
VEGA: 9
HGNC: HGNC:9060
Homologene: 21252
Skint1
Name: selection and upkeep of intraepithelial T cells 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 639781
Homologene: 87538
Birc3
Name: baculoviral IAP repeat-containing 3
Synonyms: HIAP2, MIHC, cIAP-2, Api2, RNF49, IAP2, cIAP2, MIAP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11796
HGNC: HGNC:591
Homologene: 899
Mrpl40
Name: mitochondrial ribosomal protein L40
Synonyms: Nlvcf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 18100
Homologene: 2800
Lhx1
Name: LIM homeobox protein 1
Synonyms: Lim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16869
HGNC: HGNC:6593
Homologene: 4068
Rps2
Name: ribosomal protein S2
Synonyms: Rps2, Llrep3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16898
Homologene: 37714
Pcna-ps2
Name: proliferating cell nuclear antigen pseudogene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18540
VEGA: 19
Pmvk
Name: phosphomevalonate kinase
Synonyms: 1110011E12Rik, 2900002L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68603
HGNC: HGNC:9141
Homologene: 4779
P3h4
Name: prolyl 3-hydroxylase family member 4 (non-enzymatic)
Synonyms: Leprel4, 1110036O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66180
Homologene: 4713
Slc50a1
Name: solute carrier family 50 (sugar transporter), member 1
Synonyms: Rag1ap1, Rga
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19729
Homologene: 40647
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,612,263 bp
  • T to A, chromosome 1 at 134,483,820 bp
  • T to C, chromosome 1 at 136,100,667 bp
  • T to C, chromosome 2 at 5,565,665 bp
  • A to G, chromosome 2 at 33,243,628 bp
  • G to C, chromosome 2 at 66,699,873 bp
  • A to T, chromosome 2 at 146,388,569 bp
  • G to A, chromosome 2 at 154,632,289 bp
  • G to A, chromosome 3 at 88,981,584 bp
  • T to C, chromosome 3 at 89,269,153 bp
  • G to T, chromosome 3 at 89,464,369 bp
  • A to T, chromosome 3 at 93,203,449 bp
  • A to T, chromosome 3 at 94,502,963 bp
  • C to T, chromosome 3 at 96,151,960 bp
  • A to G, chromosome 3 at 145,129,010 bp
  • T to A, chromosome 3 at 152,379,476 bp
  • G to A, chromosome 3 at 152,379,596 bp
  • A to T, chromosome 4 at 56,787,807 bp
  • T to C, chromosome 4 at 108,512,923 bp
  • T to A, chromosome 4 at 112,021,523 bp
  • A to C, chromosome 4 at 141,639,693 bp
  • G to A, chromosome 4 at 145,292,687 bp
  • T to C, chromosome 5 at 101,869,989 bp
  • T to C, chromosome 5 at 110,332,463 bp
  • T to C, chromosome 5 at 113,943,120 bp
  • C to T, chromosome 5 at 120,679,070 bp
  • T to C, chromosome 5 at 150,543,221 bp
  • A to G, chromosome 6 at 42,276,637 bp
  • G to A, chromosome 6 at 42,320,979 bp
  • A to G, chromosome 6 at 47,840,704 bp
  • A to G, chromosome 6 at 91,157,542 bp
  • T to G, chromosome 6 at 122,850,622 bp
  • G to T, chromosome 7 at 17,051,146 bp
  • T to G, chromosome 7 at 26,816,640 bp
  • T to C, chromosome 7 at 30,732,347 bp
  • T to A, chromosome 7 at 120,133,339 bp
  • T to A, chromosome 7 at 127,194,799 bp
  • T to C, chromosome 8 at 125,753,728 bp
  • A to C, chromosome 9 at 7,849,346 bp
  • T to A, chromosome 9 at 108,583,733 bp
  • G to A, chromosome 9 at 108,845,727 bp
  • T to C, chromosome 9 at 119,076,172 bp
  • A to T, chromosome 11 at 29,209,356 bp
  • A to T, chromosome 11 at 62,857,716 bp
  • A to T, chromosome 11 at 67,353,658 bp
  • C to A, chromosome 11 at 84,522,239 bp
  • G to T, chromosome 11 at 100,414,017 bp
  • T to A, chromosome 12 at 30,003,046 bp
  • A to G, chromosome 12 at 69,596,795 bp
  • A to T, chromosome 12 at 113,490,202 bp
  • A to G, chromosome 12 at 119,202,536 bp
  • G to A, chromosome 13 at 30,707,961 bp
  • T to C, chromosome 13 at 49,067,306 bp
  • A to G, chromosome 16 at 18,872,385 bp
  • A to T, chromosome 16 at 55,866,201 bp
  • T to C, chromosome 17 at 24,505,265 bp
  • A to T, chromosome 17 at 24,720,916 bp
  • A to G, chromosome 17 at 71,967,526 bp
  • C to G, chromosome 18 at 61,309,093 bp
  • T to C, chromosome 18 at 63,113,934 bp
  • G to T, chromosome 18 at 77,643,206 bp
  • C to T, chromosome 18 at 80,752,789 bp
  • A to G, chromosome 19 at 9,284,099 bp
  • T to C, chromosome 19 at 56,570,584 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5877 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044083-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.