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Strain Name:
C57BL/6J-MtgxR5878Btlr/Mmmh
Stock Number:
044084-MU
Citation ID:
RRID:MMRRC_044084-MU
Other Names:
R5878 (G1)
Major Collection:

Strain Information

Aggf1
Name: angiogenic factor with G patch and FHA domains 1
Synonyms: 2310029P06Rik, VG5Q, 2010009L17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66549
Homologene: 41220
Pi4k2a
Name: phosphatidylinositol 4-kinase type 2 alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 84095
VEGA: 19
Homologene: 101681
Gldc
Name: glycine decarboxylase
Synonyms: D19Wsu57e, D030049L12Rik, b2b2679Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Arfgef2
Name: ARF guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Ybx3
Name: Y box protein 3
Synonyms: MSY4, dbpA, oxyR, Dpba, Yb2, MSY3, Csda
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56449
HGNC: HGNC:2428
Homologene: 2708
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227446
Homologene: 10834
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 67,157,878 bp
  • A to T, chromosome 1 at 71,346,633 bp
  • A to G, chromosome 1 at 75,170,510 bp
  • T to A, chromosome 1 at 98,463,836 bp
  • T to A, chromosome 1 at 105,692,960 bp
  • T to C, chromosome 1 at 132,229,202 bp
  • T to C, chromosome 2 at 5,229,016 bp
  • G to A, chromosome 2 at 130,636,539 bp
  • C to T, chromosome 2 at 146,889,601 bp
  • A to G, chromosome 2 at 166,870,217 bp
  • A to T, chromosome 3 at 51,661,230 bp
  • T to C, chromosome 3 at 84,594,442 bp
  • T to A, chromosome 3 at 86,546,718 bp
  • A to T, chromosome 4 at 62,306,908 bp
  • G to A, chromosome 4 at 74,153,610 bp
  • G to C, chromosome 5 at 8,059,353 bp
  • T to A, chromosome 5 at 30,930,875 bp
  • G to T, chromosome 5 at 38,277,822 bp
  • T to C, chromosome 5 at 103,477,118 bp
  • T to A, chromosome 5 at 120,132,867 bp
  • C to A, chromosome 6 at 23,247,581 bp
  • T to C, chromosome 6 at 24,955,173 bp
  • A to G, chromosome 6 at 120,514,524 bp
  • C to A, chromosome 6 at 124,728,785 bp
  • A to G, chromosome 6 at 131,367,763 bp
  • A to G, chromosome 7 at 30,241,347 bp
  • A to G, chromosome 7 at 56,124,248 bp
  • A to G, chromosome 7 at 72,214,108 bp
  • T to A, chromosome 7 at 89,848,006 bp
  • A to T, chromosome 7 at 108,645,739 bp
  • A to T, chromosome 8 at 4,748,742 bp
  • A to G, chromosome 8 at 76,908,268 bp
  • A to G, chromosome 8 at 106,689,168 bp
  • C to T, chromosome 9 at 40,187,571 bp
  • G to A, chromosome 9 at 63,547,990 bp
  • T to C, chromosome 9 at 111,366,685 bp
  • T to C, chromosome 10 at 92,964,561 bp
  • T to C, chromosome 11 at 57,317,802 bp
  • A to G, chromosome 11 at 67,192,504 bp
  • G to A, chromosome 11 at 70,695,982 bp
  • G to A, chromosome 11 at 72,253,391 bp
  • T to A, chromosome 12 at 113,397,239 bp
  • T to A, chromosome 13 at 77,952,067 bp
  • T to C, chromosome 13 at 95,369,557 bp
  • A to G, chromosome 13 at 100,299,673 bp
  • G to A, chromosome 14 at 8,028,286 bp
  • T to A, chromosome 14 at 32,217,662 bp
  • A to G, chromosome 14 at 51,070,992 bp
  • T to C, chromosome 14 at 54,148,798 bp
  • C to T, chromosome 14 at 64,028,906 bp
  • T to A, chromosome 14 at 106,106,941 bp
  • A to G, chromosome 15 at 96,692,584 bp
  • A to G, chromosome 17 at 8,949,372 bp
  • A to G, chromosome 17 at 15,402,240 bp
  • T to G, chromosome 17 at 27,110,862 bp
  • A to G, chromosome 17 at 32,047,675 bp
  • C to T, chromosome 17 at 34,846,117 bp
  • T to A, chromosome 17 at 46,194,325 bp
  • G to T, chromosome 18 at 37,687,686 bp
  • T to A, chromosome 19 at 7,926,757 bp
  • T to G, chromosome 19 at 9,008,342 bp
  • T to A, chromosome 19 at 12,770,320 bp
  • A to T, chromosome 19 at 30,143,467 bp
  • T to C, chromosome 19 at 42,100,641 bp
  • T to C, chromosome 19 at 56,915,675 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5878 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044084-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.