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Strain Name:
C57BL/6J-MtgxR5891Btlr/Mmmh
Stock Number:
044092-MU
Citation ID:
RRID:MMRRC_044092-MU
Other Names:
R5891 (G1)
Major Collection:

Strain Information

Septin4
Name: septin 4
Synonyms: cell division control-related protein 2b, Pnutl2, Bh5, septin H5, Gm11492, ARTS, Sept4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18952
HGNC: HGNC:9165
Homologene: 6107
Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: BC032203, Gltscr1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Tead3
Name: TEA domain family member 3
Synonyms: ETFR-1, TEAD-3, DTEF-1, Tcf13r2, TEF-5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21678
Homologene: 81821
Cep83
Name: centrosomal protein 83
Synonyms: 2600001G24Rik, 5730513H21Rik, 4921537D05Rik, Ccdc41
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77048
VEGA: 10
Homologene: 9396
Dnajc2
Name: DnaJ heat shock protein family (Hsp40) member C2
Synonyms: MIDA1, Mida1, Zrf1, Zrf2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22791
Homologene: 31656
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 12,990,402 bp
  • T to C, chromosome 1 at 24,289,725 bp
  • A to T, chromosome 1 at 53,347,977 bp
  • A to G, chromosome 1 at 65,202,737 bp
  • G to T, chromosome 1 at 75,311,812 bp
  • C to A, chromosome 1 at 88,241,615 bp
  • A to G, chromosome 1 at 107,605,845 bp
  • T to C, chromosome 1 at 155,233,047 bp
  • A to G, chromosome 2 at 18,673,815 bp
  • T to A, chromosome 2 at 37,084,978 bp
  • T to A, chromosome 2 at 73,274,251 bp
  • A to G, chromosome 2 at 76,745,741 bp
  • A to T, chromosome 2 at 111,621,433 bp
  • T to A, chromosome 2 at 118,761,383 bp
  • G to T, chromosome 2 at 120,023,932 bp
  • A to G, chromosome 2 at 127,247,134 bp
  • G to T, chromosome 3 at 36,671,022 bp
  • T to A, chromosome 3 at 81,954,254 bp
  • C to A, chromosome 3 at 95,682,313 bp
  • A to G, chromosome 3 at 97,208,888 bp
  • T to C, chromosome 4 at 44,895,838 bp
  • T to A, chromosome 4 at 139,408,626 bp
  • T to C, chromosome 4 at 141,775,392 bp
  • T to C, chromosome 4 at 147,826,774 bp
  • A to T, chromosome 5 at 21,761,711 bp
  • A to G, chromosome 5 at 34,870,823 bp
  • A to G, chromosome 5 at 76,542,144 bp
  • A to G, chromosome 5 at 92,348,224 bp
  • A to G, chromosome 5 at 113,850,811 bp
  • A to G, chromosome 5 at 142,815,171 bp
  • A to G, chromosome 6 at 17,491,539 bp
  • A to T, chromosome 6 at 29,529,425 bp
  • T to A, chromosome 6 at 40,744,348 bp
  • A to T, chromosome 6 at 67,360,690 bp
  • T to A, chromosome 6 at 72,637,051 bp
  • A to G, chromosome 6 at 86,707,443 bp
  • A to T, chromosome 6 at 136,559,977 bp
  • T to A, chromosome 7 at 3,219,259 bp
  • C to A, chromosome 7 at 17,151,793 bp
  • T to C, chromosome 7 at 48,312,259 bp
  • T to C, chromosome 7 at 48,482,246 bp
  • T to A, chromosome 7 at 100,639,247 bp
  • C to T, chromosome 7 at 107,815,180 bp
  • T to A, chromosome 7 at 121,132,360 bp
  • C to T, chromosome 7 at 140,336,600 bp
  • T to A, chromosome 8 at 45,270,666 bp
  • A to G, chromosome 8 at 93,203,266 bp
  • T to A, chromosome 8 at 120,084,900 bp
  • G to T, chromosome 8 at 124,030,856 bp
  • T to C, chromosome 9 at 53,497,159 bp
  • C to G, chromosome 9 at 75,004,386 bp
  • T to G, chromosome 9 at 79,819,860 bp
  • T to A, chromosome 9 at 108,808,609 bp
  • G to A, chromosome 10 at 10,377,847 bp
  • T to C, chromosome 10 at 12,941,815 bp
  • A to G, chromosome 10 at 77,582,440 bp
  • T to C, chromosome 10 at 94,725,675 bp
  • T to A, chromosome 10 at 107,576,895 bp
  • T to A, chromosome 10 at 115,220,308 bp
  • T to A, chromosome 10 at 128,121,322 bp
  • G to A, chromosome 11 at 20,647,884 bp
  • G to T, chromosome 11 at 87,588,924 bp
  • T to A, chromosome 11 at 94,334,863 bp
  • C to A, chromosome 12 at 71,944,149 bp
  • A to T, chromosome 12 at 85,796,228 bp
  • T to C, chromosome 12 at 103,424,058 bp
  • T to C, chromosome 12 at 110,614,220 bp
  • T to A, chromosome 12 at 112,042,719 bp
  • C to A, chromosome 12 at 113,597,629 bp
  • T to G, chromosome 14 at 64,788,405 bp
  • A to G, chromosome 15 at 8,188,589 bp
  • C to T, chromosome 15 at 71,525,803 bp
  • T to A, chromosome 15 at 98,122,690 bp
  • T to C, chromosome 16 at 5,212,131 bp
  • A to T, chromosome 16 at 56,606,133 bp
  • C to T, chromosome 16 at 75,598,837 bp
  • A to T, chromosome 17 at 28,341,365 bp
  • T to C, chromosome 17 at 46,801,229 bp
  • A to G, chromosome 18 at 76,299,975 bp
  • T to A, chromosome 19 at 40,912,433 bp
  • A to T, chromosome Y at 1,341,535 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5891 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044092-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.