Strain Name:
C57BL/6J-MtgxR5892Btlr
Stock Number:
044093-MU
Citation ID:
RRID:MMRRC_044093-MU
Other Names:
R5892 (G1)
Major Collection:

Gene Information

Unc93b1
Name: unc-93 homolog B1, TLR signaling regulator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54445
Homologene: 41325
Prdm16
Name: PR domain containing 16
Synonyms: Mel1, line 27, csp1, 5730557K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70673
Homologene: 11139
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Enox1
Name: ecto-NOX disulfide-thiol exchanger 1
Synonyms: D230005D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239188
VEGA: 14
Homologene: 56793
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108989
Homologene: 37753
Ints8
Name: integrator complex subunit 8
Synonyms: D130008D20Rik, 2810013E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72656
Homologene: 9888
Cep170
Name: centrosomal protein 170
Synonyms: 4933426L22Rik, A330004A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545389
Homologene: 22844
Slc30a5
Name: solute carrier family 30 (zinc transporter), member 5
Synonyms: 1810010K08Rik, Znt5, Zntl1, ZnT-5, ZTL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69048
VEGA: 13
Homologene: 41503
Fubp1
Name: far upstream element (FUSE) binding protein 1
Synonyms: Fubp4, Fubp, FBP, 9530027K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51886
HGNC: HGNC:4004
Homologene: 48253
Robo2
Name: roundabout guidance receptor 2
Synonyms: D230004I22Rik, 2600013A04Rik, 9430089E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268902
Homologene: 43188
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Prmt5
Name: protein arginine N-methyltransferase 5
Synonyms: Jbp1, Jak-binding protein 1, Skb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 27374
Homologene: 4454
Ino80
Name: INO80 complex subunit
Synonyms: INO80, 2310079N15Rik, Inoc1, 4632409L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68142
Homologene: 75070
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, Myst3, 9930021N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244349
Homologene: 4924
Siglecg
Name: sialic acid binding Ig-like lectin G
Synonyms: mSiglec-G, A630096C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243958
Homologene: 13228
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76131
Homologene: 9834
Nelfe
Name: negative elongation factor complex member E, Rdbp
Synonyms: NELF-E, Rdbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 27632
Homologene: 134736
Adtrp
Name: androgen dependent TFPI regulating protein
Synonyms: 9530008L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109254
Homologene: 13107
Fer1l6
Name: fer-1-like 6 (C. elegans)
Synonyms: EG631797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 631797
Homologene: 53396
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268933
Homologene: 6870
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195046
Homologene: 133820
Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms: Bsep, ABC16, sister of P-glycoprotein, PGY4, Lith1, PFIC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MyHC-IIa, MHC2A, Myhs-f, Myhsf1, Myhs-f1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: SNM1, 2810043H12Rik, SMN1a, mSNM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 55947
Homologene: 8920
Plekha6
Name: pleckstrin homology domain containing, family A member 6
Synonyms: Pepp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240753
Homologene: 135779
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Zfp110
Name: zinc finger protein 110
Synonyms: NRIF, 2900024E01Rik, Nrif1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 65020
Homologene: 129707
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69922
Homologene: 55966
Ppox
Name: protoporphyrinogen oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19044
HGNC: HGNC:9280
Homologene: 262
Zfp963
Name: zinc finger protein 963
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 620419
Homologene: 49795
Nat3
Name: N-acetyltransferase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17962
Homologene: 69026
Gpr137b
Name: G protein-coupled receptor 137B
Synonyms: Tm7sf1, C80741, 2310041G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 83924
VEGA: 13
Homologene: 2454
Cntnap3
Name: contactin associated protein-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238680
VEGA: 13
Homologene: 129602
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238205
Homologene: 17582
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320709
VEGA: 15
Homologene: 12992
P4ha2
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
Synonyms: P4hl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18452
HGNC: HGNC:8547
Homologene: 55806
Tex29
Name: testis expressed 29
Synonyms: 1700018L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75528
Muc1
Name: mucin 1, transmembrane
Synonyms: EMA, Muc-1, CD227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Mfsd1
Name: major facilitator superfamily domain containing 1
Synonyms: 1200003O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66868
Homologene: 11228
4930524J08Rik
Name: RIKEN cDNA 4930524J08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Plekha2
Name: pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
Synonyms: TAPP2, 6430512N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 83436
Homologene: 41822
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: 8430438D04Rik, D330034A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 278279
Homologene: 25521
Gzmk
Name: granzyme K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14945
HGNC: HGNC:4711
Homologene: 20485
Fam107b
Name: family with sequence similarity 107, member B
Synonyms: 3110001A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66540
Homologene: 75316
Malrd1
Name: MAM and LDL receptor class A domain containing 1
Synonyms: Gm13364, Gm13318, Diet1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 102635496
Homologene: 136214
Gm20402
Name: predicted gene 20402
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,337,593 bp
  • G to C, chromosome 1 at 133,272,307 bp
  • T to A, chromosome 1 at 150,407,400 bp
  • C to T, chromosome 1 at 171,277,461 bp
  • T to A, chromosome 1 at 176,755,387 bp
  • A to G, chromosome 2 at 3,778,564 bp
  • A to G, chromosome 2 at 15,614,267 bp
  • C to T, chromosome 2 at 69,261,500 bp
  • T to A, chromosome 2 at 69,442,776 bp
  • A to T, chromosome 2 at 119,439,547 bp
  • G to A, chromosome 3 at 52,268,949 bp
  • A to G, chromosome 3 at 67,589,829 bp
  • C to T, chromosome 3 at 89,230,993 bp
  • A to G, chromosome 3 at 152,218,314 bp
  • G to C, chromosome 3 at 159,526,669 bp
  • T to C, chromosome 4 at 11,223,813 bp
  • T to C, chromosome 4 at 154,323,259 bp
  • A to T, chromosome 5 at 14,521,171 bp
  • G to T, chromosome 5 at 99,979,265 bp
  • T to A, chromosome 6 at 85,620,903 bp
  • C to T, chromosome 7 at 12,848,478 bp
  • G to A, chromosome 7 at 43,412,204 bp
  • A to G, chromosome 7 at 81,295,691 bp
  • C to T, chromosome 8 at 11,854,288 bp
  • A to G, chromosome 8 at 22,938,289 bp
  • C to T, chromosome 8 at 25,052,365 bp
  • T to A, chromosome 8 at 67,547,938 bp
  • T to C, chromosome 8 at 69,743,377 bp
  • T to C, chromosome 9 at 109,111,707 bp
  • C to T, chromosome 10 at 105,413,505 bp
  • A to T, chromosome 11 at 26,534,372 bp
  • A to G, chromosome 11 at 54,120,188 bp
  • A to T, chromosome 11 at 67,185,176 bp
  • A to T, chromosome 11 at 71,099,645 bp
  • A to G, chromosome 12 at 61,843,418 bp
  • T to C, chromosome 13 at 13,359,406 bp
  • A to T, chromosome 13 at 41,828,206 bp
  • A to G, chromosome 13 at 64,799,180 bp
  • T to C, chromosome 13 at 100,813,302 bp
  • C to T, chromosome 13 at 113,173,922 bp
  • C to A, chromosome 14 at 7,907,183 bp
  • A to T, chromosome 14 at 54,509,911 bp
  • A to G, chromosome 14 at 77,486,017 bp
  • A to G, chromosome 15 at 58,564,068 bp
  • T to A, chromosome 15 at 94,638,139 bp
  • T to A, chromosome 16 at 73,895,780 bp
  • A to T, chromosome 17 at 25,827,986 bp
  • T to C, chromosome 17 at 34,854,669 bp
  • A to T, chromosome 19 at 3,943,632 bp
  • T to C, chromosome 19 at 56,547,140 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5892 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044093-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.