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Strain Name:
C57BL/6J-MtgxR5910Btlr
Stock Number:
044107-MU
Citation ID:
RRID:MMRRC_044107-MU
Other Names:
R5910 (G1)
Major Collection:

Strain Information

Hnrnpab
Name: heterogeneous nuclear ribonucleoprotein A/B
Synonyms: CBF-A, Cgbfa, Hnrpab
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15384
HGNC: HGNC:5034
Homologene: 74950
Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Prkcd
Name: protein kinase C, delta
Synonyms: PKCdelta, PKC[d], Pkcd, D14Ertd420e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18753
HGNC: HGNC:9399
Homologene: 55963
Phf12
Name: PHD finger protein 12
Synonyms: PF1, 2410142K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268448
Homologene: 10841
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Eif4e2
Name: eukaryotic translation initiation factor 4E member 2
Synonyms: D0H0S6743E, 2700069E09Rik, Eif4el3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26987
HGNC: HGNC:3293
Homologene: 128466
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 85,681,140 bp
  • T to A, chromosome 1 at 87,220,974 bp
  • A to T, chromosome 1 at 87,968,400 bp
  • A to G, chromosome 1 at 91,527,745 bp
  • T to C, chromosome 1 at 92,588,707 bp
  • T to A, chromosome 1 at 151,770,827 bp
  • A to G, chromosome 2 at 25,363,433 bp
  • A to G, chromosome 2 at 28,036,888 bp
  • A to G, chromosome 2 at 59,977,426 bp
  • A to G, chromosome 2 at 89,993,438 bp
  • G to C, chromosome 2 at 114,196,232 bp
  • A to G, chromosome 2 at 150,815,700 bp
  • G to A, chromosome 2 at 158,324,557 bp
  • A to G, chromosome 3 at 88,635,020 bp
  • C to T, chromosome 3 at 89,091,720 bp
  • T to A, chromosome 3 at 89,350,424 bp
  • T to C, chromosome 3 at 103,344,576 bp
  • C to A, chromosome 3 at 132,906,418 bp
  • A to T, chromosome 4 at 47,289,514 bp
  • A to G, chromosome 4 at 106,380,468 bp
  • A to G, chromosome 4 at 117,002,134 bp
  • T to C, chromosome 5 at 3,693,217 bp
  • A to T, chromosome 5 at 65,388,701 bp
  • T to C, chromosome 5 at 72,540,365 bp
  • T to C, chromosome 5 at 97,096,028 bp
  • T to A, chromosome 5 at 114,415,309 bp
  • A to G, chromosome 5 at 120,547,397 bp
  • A to T, chromosome 5 at 140,702,218 bp
  • A to G, chromosome 6 at 30,957,839 bp
  • A to T, chromosome 6 at 34,891,487 bp
  • A to G, chromosome 6 at 121,668,117 bp
  • C to A, chromosome 6 at 146,329,571 bp
  • C to T, chromosome 7 at 28,085,503 bp
  • C to T, chromosome 7 at 44,996,543 bp
  • A to G, chromosome 7 at 46,298,598 bp
  • T to A, chromosome 7 at 83,884,485 bp
  • T to C, chromosome 7 at 97,390,286 bp
  • A to G, chromosome 7 at 121,738,095 bp
  • A to G, chromosome 7 at 141,598,778 bp
  • A to G, chromosome 7 at 141,861,311 bp
  • T to C, chromosome 7 at 145,260,982 bp
  • T to C, chromosome 8 at 74,999,565 bp
  • T to G, chromosome 8 at 125,491,684 bp
  • C to T, chromosome 9 at 43,134,474 bp
  • T to C, chromosome 9 at 44,359,135 bp
  • A to T, chromosome 9 at 53,448,080 bp
  • T to A, chromosome 10 at 23,824,667 bp
  • A to G, chromosome 10 at 60,377,821 bp
  • A to T, chromosome 10 at 78,577,113 bp
  • A to G, chromosome 10 at 79,743,497 bp
  • G to T, chromosome 10 at 79,973,021 bp
  • A to T, chromosome 10 at 81,496,078 bp
  • A to T, chromosome 10 at 93,065,181 bp
  • T to C, chromosome 11 at 51,601,454 bp
  • T to A, chromosome 11 at 61,493,621 bp
  • A to T, chromosome 11 at 69,746,870 bp
  • G to A, chromosome 11 at 78,027,398 bp
  • A to G, chromosome 11 at 96,135,589 bp
  • A to G, chromosome 11 at 102,913,544 bp
  • A to T, chromosome 11 at 104,690,934 bp
  • T to C, chromosome 12 at 31,937,652 bp
  • G to A, chromosome 12 at 101,883,479 bp
  • A to G, chromosome 13 at 21,722,300 bp
  • T to C, chromosome 13 at 38,192,469 bp
  • A to T, chromosome 13 at 93,092,643 bp
  • A to T, chromosome 14 at 30,595,981 bp
  • A to T, chromosome 14 at 33,366,615 bp
  • A to T, chromosome 14 at 55,779,013 bp
  • A to T, chromosome 14 at 75,035,472 bp
  • T to C, chromosome 15 at 39,876,043 bp
  • G to A, chromosome 15 at 63,895,252 bp
  • A to T, chromosome 16 at 10,387,153 bp
  • A to G, chromosome 16 at 19,957,094 bp
  • A to T, chromosome 16 at 48,073,463 bp
  • G to A, chromosome 16 at 85,802,149 bp
  • G to T, chromosome 17 at 90,704,318 bp
  • T to C, chromosome 18 at 37,423,743 bp
  • A to G, chromosome 19 at 15,969,128 bp
  • G to A, chromosome 19 at 47,780,271 bp
  • T to A, chromosome 19 at 56,342,311 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5910 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044107-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.