Strain Name:
C57BL/6J-MtgxR5912Btlr
Stock Number:
044109-MU
Citation ID:
RRID:MMRRC_044109-MU
Other Names:
R5912 (G1)
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: WWP3, Gukmi1, AIP3, BAP1, Baiap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66860
Homologene: 18946
Zfp710
Name: zinc finger protein 710
Synonyms: 5430400N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209225
Homologene: 19625
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56531
Homologene: 87707
Swt1
Name: SWT1 RNA endoribonuclease homolog (S. cerevisiae)
Synonyms: 1200016B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66875
Homologene: 32355
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240725
Homologene: 49408
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Serpini1
Name: serine (or cysteine) peptidase inhibitor, clade I, member 1
Synonyms: Neuroserpin, PI12, Spi17, Ns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20713
HGNC: HGNC:8943
Homologene: 21045
Rfx5
Name: regulatory factor X, 5 (influences HLA class II expression)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53970
HGNC: HGNC:9986
Zfp866
Name: zinc finger protein 866
Synonyms: 9830167H18Rik, D330038O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330788
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231214
Homologene: 18159
Traf3
Name: TNF receptor-associated factor 3
Synonyms: LAP1, CAP-1, CD40bp, CRAF1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22031
Homologene: 7981
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Glud1
Name: glutamate dehydrogenase 1
Synonyms: Gdh-X, Glud
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14661
HGNC: HGNC:4335
Homologene: 55885
Spag9
Name: sperm associated antigen 9
Synonyms: 4733401I23Rik, syd1, 4831406C20Rik, Mapk8ip4, JIP4, 3110018C07Rik, JLP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70834
Homologene: 2954
Ikzf1
Name: IKAROS family zinc finger 1
Synonyms: LyF-1, Ikaros, 5832432G11Rik, Zfpn1a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22778
Homologene: 55948
Tbc1d10b
Name: TBC1 domain family, member 10b
Synonyms: 1110003P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68449
Homologene: 9177
Kif18b
Name: kinesin family member 18B
Synonyms: N-8 kinesin, 3000004C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70218
Homologene: 15214
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Hyk, Tie2, Cd202b, tie-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21687
Homologene: 397
Zbtb5
Name: zinc finger and BTB domain containing 5
Synonyms: 9430083K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230119
Homologene: 8913
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, HL-19, DLP12, HL19, DHC3, LOC380889, 4921531P07Rik, Dnahc7l, Dnahc12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627537
Homologene: 129750
Ust
Name: uronyl-2-sulfotransferase
Synonyms: D930010O20Rik, UA2OST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338362
VEGA: 10
Homologene: 4174
Csf3r
Name: colony stimulating factor 3 receptor (granulocyte)
Synonyms: G-CSFR, Csfgr, Cd114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12986
HGNC: HGNC:2439
Homologene: 601
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: ESTM15, 1810073P09Rik, X83337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75607
Homologene: 19155
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Slc7a6
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
Synonyms: LAT-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330836
Homologene: 62496
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224079
Homologene: 75330
Cdh2
Name: cadherin 2
Synonyms: N-cadherin, Ncad, N-CAD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Sh2b1
Name: SH2B adaptor protein 1
Synonyms: Irip, SH2-Bb, SH2-B, Sh2bpsm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20399
Homologene: 32122
Clip3
Name: CAP-GLY domain containing linker protein 3
Synonyms: 1500005P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76686
Homologene: 9176
Asap2
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonyms: LOC385250, Ddef2, 6530401G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211914
HGNC: HGNC:2721
Homologene: 2888
Unc5c
Name: unc-5 netrin receptor C
Synonyms: Unc5h3, B130051O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22253
Homologene: 2765
5031439G07Rik
Name: RIKEN cDNA 5031439G07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223739
HGNC: HGNC:1314
Homologene: 15140
Nlrp4f
Name: NLR family, pyrin domain containing 4F
Synonyms: Nalp-kappa, C330026N02Rik, Nalp4f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 97895
VEGA: 13
Homologene: 87252
Klhl31
Name: kelch-like 31
Synonyms: D930047P17Rik, Kbtbd1, 9830147P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244923
Homologene: 27819
Olfr393
Name: olfactory receptor 393
Synonyms: GA_x6K02T2P1NL-4004140-4003208, MOR135-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259010
Homologene: 79335
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: M-Sema F, Semaf, Semacl1, Semai, Semacl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20353
Homologene: 23047
Bivm
Name: basic, immunoglobulin-like variable motif containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 246229
Homologene: 9783
Cyp2j13
Name: cytochrome P450, family 2, subfamily j, polypeptide 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230459
Homologene: 138297
Traf5
Name: TNF receptor-associated factor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22033
Homologene: 27079
Olfr402
Name: olfactory receptor 402
Synonyms: GA_x6K02T2P1NL-4307199-4308146, MOR255-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258703
HGNC: HGNC:8282
Homologene: 1915
Gsg1l2
Name: GSG1-like 2
Synonyms: Gm12302
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544792
Homologene: 132038
Spdye4c
Name: speedy/RINGO cell cycle regulator family, member E4C
Synonyms: LOC241634, Gm355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241634
Homologene: 78093
Scn1b
Name: sodium channel, voltage-gated, type I, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20266
Homologene: 810
Gm5805
Name: predicted gene 5805
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 102634709
VEGA: 15
Homologene: 138948
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 12,786,752 bp
  • A to C, chromosome 1 at 36,554,388 bp
  • G to T, chromosome 1 at 44,126,413 bp
  • A to G, chromosome 1 at 151,411,409 bp
  • A to G, chromosome 1 at 191,998,069 bp
  • T to C, chromosome 2 at 59,791,686 bp
  • A to T, chromosome 2 at 76,810,343 bp
  • C to T, chromosome 2 at 128,596,074 bp
  • A to G, chromosome 2 at 180,195,475 bp
  • G to T, chromosome 3 at 75,616,607 bp
  • G to A, chromosome 3 at 94,958,718 bp
  • A to G, chromosome 3 at 141,789,006 bp
  • A to G, chromosome 4 at 44,993,750 bp
  • A to G, chromosome 4 at 94,798,640 bp
  • A to T, chromosome 4 at 96,056,842 bp
  • A to C, chromosome 4 at 123,397,158 bp
  • A to T, chromosome 4 at 126,029,960 bp
  • A to G, chromosome 5 at 25,347,469 bp
  • A to C, chromosome 5 at 43,720,430 bp
  • A to T, chromosome 6 at 93,708,145 bp
  • A to C, chromosome 7 at 30,298,870 bp
  • C to T, chromosome 7 at 31,117,803 bp
  • A to G, chromosome 7 at 80,081,474 bp
  • A to T, chromosome 7 at 118,154,586 bp
  • T to C, chromosome 7 at 126,471,470 bp
  • G to T, chromosome 7 at 127,199,861 bp
  • A to T, chromosome 8 at 69,766,284 bp
  • G to T, chromosome 8 at 106,179,657 bp
  • C to A, chromosome 9 at 77,655,730 bp
  • A to G, chromosome 10 at 8,298,061 bp
  • C to A, chromosome 11 at 11,748,464 bp
  • G to T, chromosome 11 at 67,774,714 bp
  • A to C, chromosome 11 at 73,847,675 bp
  • A to T, chromosome 11 at 74,155,220 bp
  • A to G, chromosome 11 at 94,044,425 bp
  • A to G, chromosome 11 at 102,912,991 bp
  • T to C, chromosome 12 at 21,206,343 bp
  • G to A, chromosome 12 at 75,908,947 bp
  • C to T, chromosome 12 at 85,040,886 bp
  • A to G, chromosome 12 at 111,255,349 bp
  • T to C, chromosome 13 at 49,060,774 bp
  • A to T, chromosome 13 at 65,194,908 bp
  • T to A, chromosome 14 at 26,770,008 bp
  • G to A, chromosome 14 at 34,311,343 bp
  • A to G, chromosome 15 at 81,972,817 bp
  • A to T, chromosome 15 at 84,955,696 bp
  • A to G, chromosome 16 at 29,456,571 bp
  • A to G, chromosome 17 at 19,531,809 bp
  • A to C, chromosome 18 at 16,640,450 bp
  • T to A, chromosome 19 at 9,011,903 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5912 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044109-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.