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Strain Name:
C57BL/6J-MtgxR5915Btlr
Stock Number:
044112-MU
Citation ID:
RRID:MMRRC_044112-MU
Other Names:
R5915 (G1)
Major Collection:

Strain Information

Gulo
Name: gulonolactone (L-) oxidase
Synonyms: L-gulono-gamma-lactone oxidase, sfx
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268756
VEGA: 14
HGNC: HGNC:4695
Homologene: 6566
Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Apoa5
Name: apolipoprotein A-V
Synonyms: RAP3, Apoav, 1300007O05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66113
Homologene: 14197
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Dpy30
Name: dpy-30, histone methyltransferase complex regulatory subunit
Synonyms: 2810410M20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66310
VEGA: 17
Homologene: 32582
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74315
Homologene: 14427
Phf14
Name: PHD finger protein 14
Synonyms: 1110001C23Rik, 4932409F11Rik, 5730446A07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75725
Homologene: 8775
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 150,425,649 bp
  • A to T, chromosome 1 at 155,136,788 bp
  • A to G, chromosome 2 at 180,978,422 bp
  • TCTCCTC to TCTC, chromosome 4 at 34,769,010 bp
  • T to A, chromosome 4 at 40,977,285 bp
  • A to G, chromosome 4 at 43,370,577 bp
  • A to G, chromosome 4 at 155,656,051 bp
  • C to T, chromosome 5 at 9,511,927 bp
  • T to A, chromosome 5 at 31,785,611 bp
  • T to A, chromosome 6 at 11,933,727 bp
  • A to G, chromosome 6 at 29,379,755 bp
  • A to G, chromosome 6 at 48,464,596 bp
  • A to T, chromosome 6 at 48,491,484 bp
  • T to A, chromosome 6 at 121,667,163 bp
  • A to T, chromosome 7 at 6,570,173 bp
  • A to G, chromosome 7 at 40,902,683 bp
  • A to G, chromosome 7 at 48,552,806 bp
  • A to G, chromosome 7 at 80,360,921 bp
  • A to G, chromosome 7 at 105,617,975 bp
  • A to T, chromosome 7 at 110,378,096 bp
  • T to A, chromosome 8 at 36,938,675 bp
  • A to G, chromosome 8 at 61,533,352 bp
  • G to T, chromosome 8 at 70,098,081 bp
  • A to G, chromosome 9 at 15,341,479 bp
  • C to T, chromosome 9 at 22,249,834 bp
  • C to A, chromosome 9 at 46,269,309 bp
  • T to C, chromosome 9 at 107,545,078 bp
  • A to T, chromosome 10 at 121,615,093 bp
  • T to C, chromosome 11 at 44,542,722 bp
  • A to G, chromosome 11 at 48,845,650 bp
  • C to T, chromosome 11 at 51,756,137 bp
  • C to T, chromosome 11 at 58,968,562 bp
  • T to C, chromosome 11 at 70,318,224 bp
  • T to C, chromosome 11 at 99,993,618 bp
  • A to G, chromosome 11 at 101,263,894 bp
  • G to A, chromosome 11 at 120,466,605 bp
  • A to T, chromosome 12 at 40,213,096 bp
  • C to T, chromosome 12 at 85,040,886 bp
  • G to T, chromosome 13 at 49,078,085 bp
  • A to G, chromosome 13 at 65,187,555 bp
  • G to A, chromosome 13 at 99,430,331 bp
  • A to T, chromosome 14 at 66,008,121 bp
  • T to C, chromosome 15 at 12,935,066 bp
  • T to C, chromosome 15 at 58,790,188 bp
  • C to T, chromosome 15 at 85,937,975 bp
  • C to T, chromosome 15 at 86,030,349 bp
  • G to A, chromosome 16 at 11,164,602 bp
  • A to T, chromosome 16 at 56,730,385 bp
  • G to A, chromosome 16 at 84,809,407 bp
  • A to C, chromosome 17 at 25,567,469 bp
  • G to T, chromosome 17 at 74,315,911 bp
  • A to G, chromosome 18 at 6,037,016 bp
  • A to G, chromosome 19 at 5,463,616 bp
  • C to G, chromosome Y at 2,662,612 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5915 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044112-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.