Strain Name:
C57BL/6J-MtgxR5925Btlr/Mmmh
Stock Number:
044120-MU
Citation ID:
RRID:MMRRC_044120-MU
Other Names:
R5925 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Lmo4
Name: LIM domain only 4
Synonyms: Crp3, Etohi4, A730077C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16911
HGNC: HGNC:6644
Homologene: 4927
Diaph1
Name: diaphanous related formin 1
Synonyms: p140mDia, Drf1, Dia1, D18Wsu154e, mDia1, Diap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13367
HGNC: HGNC:2876
Homologene: 129567
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 1110036I07Rik, 6720416K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14897
Homologene: 44226
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71643
Homologene: 34708
Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
Synonyms: Pir121, 6430511D02Rik, 1500004I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76884
Homologene: 7936
Malt1
Name: MALT1 paracaspase
Synonyms: D430033E09Rik, paracaspase, Pcasp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240354
HGNC: HGNC:6819
Homologene: 4938
Satb2
Name: special AT-rich sequence binding protein 2
Synonyms: BAP002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 212712
Homologene: 32249
Tpd52l1
Name: tumor protein D52-like 1
Synonyms: D53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21987
VEGA: 10
Homologene: 2468
Ccdc187
Name: coiled-coil domain containing 187
Synonyms: 4932418E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329366
Homologene: 77630
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Mpzl3
Name: myelin protein zero-like 3
Synonyms: 5430427F17Rik, rc, A530065I17Rik, ruf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319742
Homologene: 18867
Zfp37
Name: zinc finger protein 37
Synonyms: Tzn, Zfp-37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22696
Homologene: 40682
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, PM-Scl, RRP6, p4, p3, p2, Pmscl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Cep95
Name: centrosomal protein 95
Synonyms: F630025I20Rik, 4732496G21Rik, Ccdc45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320162
Homologene: 16297
Dync2i1
Name: dynein 2 intermediate chain 1
Synonyms: D430033N04Rik, Wdr60, Dync2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217935
VEGA: 12
Homologene: 23067
Slc35e2
Name: solute carrier family 35, member E2
Synonyms: A530082C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320541
Homologene: 84987
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Bltp2
Name: bridge-like lipid transfer protein family member 2
Synonyms: 2610507B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72503
Homologene: 34730
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: Si-s, sucrase-isomaltase, 2010204N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69983
Homologene: 37424
Afp
Name: alpha fetoprotein
Synonyms: alpha-foetoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11576
HGNC: HGNC:317
Homologene: 36278
Hc
Name: hemolytic complement
Synonyms: C5a, C5, He, Hfib2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Nlrp14
Name: NLR family, pyrin domain containing 14
Synonyms: 4921520L01Rik, Nalp14, GC-LRR, Nalp-iota
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76858
Homologene: 18531
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Fish, Sh3md1, Tks5, 2310014D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Flg
Name: filaggrin
Synonyms: profilaggrin, fillagrin, ft
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14246
VEGA: 3
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Abca8a
Name: ATP-binding cassette, sub-family A (ABC1), member 8a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Pcdha1
Name: protocadherin alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 116731
HGNC: HGNC:8663
Homologene: 75093
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Dist1, Egfr-rs, Dist
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13650
Homologene: 32085
Or6c76b
Name: olfactory receptor family 6 subfamily C member 76B
Synonyms: GA_x6K02T2PULF-11535078-11536010, MOR108-3, Olfr813
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258252
Homologene: 138308
Or2g1
Name: olfactory receptor family 2 subfamily G member 1
Synonyms: MOR256-9, GA_x6K02T2PSCP-2255106-2256035, Olfr123
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258623
Homologene: 105169
Antxr1
Name: anthrax toxin receptor 1
Synonyms: 2810405N18Rik, 2310008J16Rik, Tem8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69538
Homologene: 12976
Prb1
Name: proline-rich protein BstNI subfamily 1
Synonyms: proline-rich proteoglycan 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381833
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: pheromone recepter, EC1-VR2, V2rf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216144
Homologene: 83483
Ehf
Name: ets homologous factor
Synonyms: 9030625L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13661
HGNC: HGNC:3246
Homologene: 7301
9130230L23Rik
Name: RIKEN cDNA 9130230L23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231253
Map3k3
Name: mitogen-activated protein kinase kinase kinase 3
Synonyms: MAPKKK3, Mekk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26406
HGNC: HGNC:6855
Homologene: 69110
Zfp39
Name: zinc finger protein 39
Synonyms: CTfin33, Zfp-39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22698
Homologene: 69102
Eif2b5
Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224045
HGNC: HGNC:3261
Homologene: 2903
Snph
Name: syntaphilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241727
Homologene: 8817
Slc35f3
Name: solute carrier family 35, member F3
Synonyms: B230375D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 210027
Homologene: 62481
Trav18
Name: T cell receptor alpha variable 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 547427
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 56,796,938 bp
  • G to A, chromosome 1 at 84,749,253 bp
  • A to G, chromosome 2 at 26,293,581 bp
  • T to A, chromosome 2 at 35,030,450 bp
  • C to T, chromosome 2 at 76,802,248 bp
  • T to C, chromosome 2 at 76,809,011 bp
  • A to T, chromosome 2 at 91,511,684 bp
  • T to C, chromosome 2 at 103,266,993 bp
  • T to C, chromosome 2 at 151,594,231 bp
  • T to C, chromosome 3 at 72,921,380 bp
  • A to T, chromosome 3 at 93,279,399 bp
  • A to C, chromosome 3 at 126,932,963 bp
  • A to G, chromosome 3 at 127,573,204 bp
  • A to T, chromosome 3 at 144,194,491 bp
  • G to A, chromosome 4 at 62,191,213 bp
  • C to A, chromosome 4 at 148,573,362 bp
  • T to C, chromosome 4 at 155,611,627 bp
  • C to T, chromosome 5 at 65,990,392 bp
  • T to A, chromosome 5 at 90,497,288 bp
  • A to G, chromosome 6 at 87,312,362 bp
  • A to G, chromosome 6 at 132,210,512 bp
  • T to A, chromosome 7 at 107,186,653 bp
  • T to C, chromosome 8 at 126,389,207 bp
  • G to T, chromosome 9 at 45,062,114 bp
  • G to T, chromosome 9 at 110,629,880 bp
  • T to C, chromosome 10 at 31,332,947 bp
  • T to C, chromosome 10 at 79,247,803 bp
  • A to G, chromosome 10 at 129,856,875 bp
  • A to G, chromosome 11 at 32,212,906 bp
  • T to C, chromosome 11 at 46,207,436 bp
  • A to T, chromosome 11 at 58,891,273 bp
  • T to C, chromosome 11 at 78,284,238 bp
  • T to C, chromosome 11 at 106,149,550 bp
  • T to C, chromosome 11 at 106,812,401 bp
  • T to C, chromosome 11 at 110,057,223 bp
  • G to C, chromosome 12 at 103,125,730 bp
  • A to T, chromosome 12 at 116,233,394 bp
  • A to G, chromosome 14 at 53,831,695 bp
  • C to T, chromosome 16 at 20,508,124 bp
  • T to C, chromosome 17 at 37,795,591 bp
  • T to A, chromosome 18 at 36,930,671 bp
  • A to G, chromosome 18 at 37,891,935 bp
  • T to A, chromosome 18 at 65,431,368 bp
  • A to T, chromosome 19 at 47,267,612 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5925 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044120-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.