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Strain Name:
C57BL/6J-MtgxR5974Btlr/Mmmh
Stock Number:
044157-MU
Citation ID:
RRID:MMRRC_044157-MU
Other Names:
R5974 (G1)
Major Collection:

Strain Information

Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: Nedd4-1, Nedd4, Nedd4a, E430025J12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Galr2
Name: galanin receptor 2
Synonyms: mGalR, GalR2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14428
HGNC: HGNC:4133
Homologene: 2863
Ctnnal1
Name: catenin alpha like 1
Synonyms: ACRP, Catnal1, catenin (cadherin associated protein), alpha-like 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54366
HGNC: HGNC:2512
Homologene: 2815
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: NBL2, 4.1G, D10Ertd398e, Epb4.1l2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Nlk
Name: nemo like kinase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18099
Homologene: 88836
Hdac11
Name: histone deacetylase 11
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232232
Homologene: 11743
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, 6720461J16Rik, D130048F08Rik, Datf1, dido, C130092D22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Coro7
Name: coronin 7
Synonyms: 0610011B16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78885
Homologene: 11573
Ywhag
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Synonyms: D7Bwg1348e, 14-3-3 gamma
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22628
Homologene: 22725
Rffl
Name: ring finger and FYVE like domain containing protein
Synonyms: 4930516L10Rik, fring, rififylin, 1700051E09Rik, Carp-2, Carp2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67338
Homologene: 12116
Ctnnd1
Name: catenin delta 1
Synonyms: P120, Ctnnd, p120-catenin, Catns, catenin (cadherin associated protein), delta 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Sgk1
Name: serum/glucocorticoid regulated kinase 1
Synonyms: Sgk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20393
Homologene: 48364
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms: Rinp, Rip1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19766
Homologene: 2820
Ticam1
Name: TIR domain containing adaptor molecule 1
Synonyms: Trif, TICAM-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106759
Homologene: 8605
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Syngap1
Name: synaptic Ras GTPase activating protein 1 homolog (rat)
Synonyms: Syngap
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240057
Homologene: 84739
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Pros1
Name: protein S (alpha)
Synonyms: protein S
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19128
HGNC: HGNC:9456
Homologene: 264
Zfp296
Name: zinc finger protein 296
Synonyms: 2210018A16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 63872
Homologene: 11185
Anapc4
Name: anaphase promoting complex subunit 4
Synonyms: 2610306D21Rik, APC4, D5Ertd249e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52206
Homologene: 40873
Zfp418
Name: zinc finger protein 418
Synonyms: A230102I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232854
Homologene: 119890
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Fbxo24
Name: F-box protein 24
Synonyms: Fbx24, 4933422D21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71176
Homologene: 14131
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: PBP, Moca
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Or8u10
Name: olfactory receptor family 8 subfamily U member 10
Synonyms: GA_x6K02T2Q125-47560740-47559775, MOR171-52, MOR256-34P, Olfr1037
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259151
Homologene: 66572
Ccnb1ip1
Name: cyclin B1 interacting protein 1
Synonyms: LOC239083, mei4, Hei10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239083
VEGA: 14
Homologene: 18819
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap-1, Mtap1, 6330416M19Rik, Mtap1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Lmbrd2
Name: LMBR1 domain containing 2
Synonyms: 9930036E21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320506
VEGA: 15
Homologene: 44696
Sox30
Name: SRY (sex determining region Y)-box 30
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214105
Homologene: 34027
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Per3
Name: period circadian clock 3
Synonyms: mPer3, 2810049O06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18628
HGNC: HGNC:8847
Homologene: 7886
Lacc1
Name: laccase domain containing 1
Synonyms: 9030625A04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210808
Homologene: 17712
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 0610043A03Rik, 2210420P05Rik, 2600014C01Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70297
Homologene: 45639
Zfp882
Name: zinc finger protein 882
Synonyms: ENSMUSG00000052439
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382019
Homologene: 136303
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Fut9
Name: fucosyltransferase 9
Synonyms: mFUT9, mFuc-TIX
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14348
HGNC: HGNC:4020
Homologene: 4800
Ebf4
Name: early B cell factor 4
Synonyms: Olf-1/EBF-like 4, O/E-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228598
Homologene: 65064
Skint1
Name: selection and upkeep of intraepithelial T cells 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 639781
Homologene: 87538
Or5an1
Name: olfactory receptor family 5 subfamily AN member 1
Synonyms: GA_x6K02T2RE5P-2618516-2619454, GA_x6K02T2RE5P-2610001-2610414, MOR214-4, MOR214-4, Olfr1433, Olfr1434
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258680
Homologene: 45029
Pknox2
Name: Pbx/knotted 1 homeobox 2
Synonyms: Prep2, D230005H23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208076
Homologene: 32527
Negr1
Name: neuronal growth regulator 1
Synonyms: Ntra, 5330422G01Rik, neurotractin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320840
Homologene: 41447
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: 1700074B05Rik, 5830409B12Rik, 4833417L20Rik, 1700024K14Rik, Rsnl2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Mrpl1
Name: mitochondrial ribosomal protein L1
Synonyms: 2410002L03Rik, 5830418D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 94061
Homologene: 41355
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269529
Homologene: 19544
Gm11127
Name: predicted gene 11127
Synonyms: Gm11127
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100529082
Homologene: 133121
Or12d12
Name: olfactory receptor family 12 subfamily D member 12
Synonyms: GA_x6K02T2PSCP-1761617-1760691, MOR250-2, Olfr101
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258831
Homologene: 133728
Aqp6
Name: aquaporin 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11831
VEGA: 15
HGNC: HGNC:639
Homologene: 20399
Nup42
Name: nucleoporin 42
Synonyms: CG1, Nupl2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231042
Homologene: 40573
Unc50
Name: unc-50 homolog
Synonyms: GMH1, 1110002A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67387
Homologene: 6391
Tmem252
Name: transmembrane protein 252
Synonyms: E030010A14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226040
VEGA: 19
Homologene: 17717
Pabpn1
Name: poly(A) binding protein, nuclear 1
Synonyms: poly(A) binding protein II, Pabp3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54196
HGNC: HGNC:8565
Homologene: 3412
Krtap11-1
Name: keratin associated protein 11-1
Synonyms: KAP11.1, Hacl1, PRED29
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16693
Homologene: 45517
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,437,209 bp
  • A to G, chromosome 1 at 51,778,373 bp
  • T to A, chromosome 1 at 75,362,984 bp
  • C to A, chromosome 2 at 69,459,548 bp
  • T to A, chromosome 2 at 82,963,313 bp
  • C to A, chromosome 2 at 84,620,915 bp
  • T to C, chromosome 2 at 86,084,881 bp
  • T to C, chromosome 2 at 121,304,376 bp
  • G to A, chromosome 2 at 130,365,564 bp
  • C to T, chromosome 2 at 142,857,381 bp
  • T to C, chromosome 2 at 180,671,497 bp
  • C to A, chromosome 3 at 27,144,963 bp
  • T to A, chromosome 3 at 157,069,286 bp
  • A to C, chromosome 4 at 25,620,090 bp
  • T to C, chromosome 4 at 45,040,631 bp
  • C to T, chromosome 4 at 47,258,683 bp
  • C to A, chromosome 4 at 56,817,067 bp
  • T to A, chromosome 4 at 112,019,319 bp
  • A to G, chromosome 4 at 139,421,078 bp
  • A to T, chromosome 4 at 151,042,737 bp
  • T to C, chromosome 5 at 24,167,402 bp
  • T to C, chromosome 5 at 52,845,400 bp
  • T to C, chromosome 5 at 96,231,794 bp
  • A to C, chromosome 5 at 135,911,629 bp
  • C to T, chromosome 5 at 137,619,650 bp
  • G to A, chromosome 6 at 91,173,214 bp
  • A to C, chromosome 7 at 3,841,577 bp
  • G to T, chromosome 7 at 7,182,200 bp
  • T to C, chromosome 7 at 19,577,937 bp
  • A to G, chromosome 7 at 45,691,424 bp
  • T to C, chromosome 8 at 71,913,155 bp
  • A to T, chromosome 9 at 16,006,528 bp
  • A to G, chromosome 9 at 36,936,322 bp
  • T to A, chromosome 9 at 72,743,638 bp
  • A to G, chromosome 9 at 79,682,127 bp
  • A to G, chromosome 9 at 106,994,062 bp
  • T to A, chromosome 10 at 21,996,249 bp
  • A to G, chromosome 10 at 25,441,815 bp
  • T to A, chromosome 10 at 58,258,243 bp
  • G to T, chromosome 11 at 45,981,073 bp
  • C to A, chromosome 11 at 59,076,547 bp
  • T to G, chromosome 11 at 78,590,966 bp
  • T to C, chromosome 11 at 82,806,151 bp
  • A to G, chromosome 11 at 116,283,026 bp
  • A to G, chromosome 13 at 11,714,511 bp
  • T to A, chromosome 13 at 34,030,101 bp
  • A to T, chromosome 14 at 50,792,205 bp
  • A to G, chromosome 14 at 54,897,160 bp
  • T to C, chromosome 14 at 77,035,077 bp
  • A to G, chromosome 15 at 9,172,115 bp
  • T to C, chromosome 15 at 97,802,072 bp
  • A to G, chromosome 15 at 99,601,436 bp
  • A to T, chromosome 16 at 4,631,889 bp
  • A to C, chromosome 16 at 62,900,667 bp
  • C to A, chromosome 16 at 89,570,768 bp
  • A to G, chromosome 17 at 3,414,809 bp
  • A to G, chromosome 17 at 26,963,038 bp
  • T to G, chromosome 17 at 34,685,707 bp
  • A to T, chromosome 17 at 36,056,785 bp
  • A to T, chromosome 17 at 37,300,338 bp
  • T to A, chromosome 17 at 49,464,473 bp
  • T to C, chromosome 17 at 56,271,178 bp
  • T to A, chromosome 17 at 57,876,485 bp
  • T to C, chromosome 17 at 67,773,727 bp
  • A to T, chromosome 17 at 71,831,247 bp
  • T to G, chromosome 18 at 58,048,920 bp
  • G to T, chromosome 18 at 67,421,259 bp
  • T to C, chromosome 19 at 12,283,836 bp
  • A to G, chromosome 19 at 24,674,268 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5974 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044157-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.