Strain Name:
C57BL/6J-MtgxR6002Btlr
Stock Number:
044181-MU
Citation ID:
RRID:MMRRC_044181-MU
Other Names:
R6002 (G1)
Major Collection:

Gene Information

Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: alpha6 nAChR, Acra6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11440
Homologene: 20888
Eif3h
Name: eukaryotic translation initiation factor 3, subunit H
Synonyms: EIF3-P40, Eif3s3, 1110008A16Rik, EIF3-gamma, 9430017H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 68135
VEGA: 15
HGNC: HGNC:3273
Homologene: 2785
Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: 2410141F18Rik, Jmjd2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 76804
Homologene: 41004
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 9030205D12Rik, 1810014J18Rik, AD013, A330063D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 109151
Homologene: 11844
Stat3
Name: signal transducer and activator of transcription 3
Synonyms: Aprf, 1110034C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20848
Homologene: 7960
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227800
Homologene: 49301
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: Grit, 3426406O18Rik, PX-RICS, GC-GAP, p200RhoGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330914
Homologene: 8812
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: Nob1, 1110062G02Rik, Nobq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 57915
Homologene: 56856
Pi4k2b
Name: phosphatidylinositol 4-kinase type 2 beta
Synonyms: 4933409G22Rik, 2610042N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 67073
Homologene: 32405
Fgf21
Name: fibroblast growth factor 21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56636
HGNC: HGNC:3678
Homologene: 10428
Ap2a1
Name: adaptor-related protein complex 2, alpha 1 subunit
Synonyms: Adtaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11771
HGNC: HGNC:561
Homologene: 68997
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: IASPP, wa3, NFkB interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 333654
Homologene: 84635
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 665700
Homologene: 90772
Sec31b
Name: Sec31 homolog B (S. cerevisiae)
Synonyms: Sec31l2, LOC240667
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 240667
Homologene: 56708
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 8430415N23Rik, 9830132G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226470
Homologene: 27795
Olfr1484
Name: olfactory receptor 1484
Synonyms: MOR202-37, GA_x6K02T2RE5P-3917859-3918806
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258288
Homologene: 110492
Coro1a
Name: coronin, actin binding protein 1A
Synonyms: coronin 1, Lmb3, Clabp, p57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12721
HGNC: HGNC:2252
Homologene: 6545
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: IGFBP-4ase, PAPP-A, PAG1, 8430414N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: 4732433M03Rik, CPS, D1Ucla3, CPSase I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: B830017A01Rik, 3110047P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 319807
Homologene: 14974
Cd96
Name: CD96 antigen
Synonyms: Tactile, 1700109I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 84544
Homologene: 68489
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: C130072N01Rik, Dtgn1, D430033C21Rik, MDC-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Cdx2
Name: caudal type homeobox 2
Synonyms: Cdx-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12591
HGNC: HGNC:1806
Homologene: 968
Prl5a1
Name: prolactin family 5, subfamily a, member 1
Synonyms: D13Wsu14e, 1600013P04Rik, Prlpl, PLP-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 28078
Homologene: 11378
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 75721
Homologene: 138468
Olfr474
Name: olfactory receptor 474
Synonyms: GA_x6K02T2PBJ9-10283869-10284801, MOR204-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258488
Pdha2
Name: pyruvate dehydrogenase E1 alpha 2
Synonyms: Pdhal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18598
HGNC: HGNC:8807
Homologene: 137212
Amer2
Name: APC membrane recruitment 2
Synonyms: Amer2, 2600011E07Rik, Fam123a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 72125
VEGA: 14
Homologene: 45141
Fbxw22
Name: F-box and WD-40 domain protein 22
Synonyms: Gm5164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382156
Homologene: 110776
Olfr463
Name: olfactory receptor 463
Synonyms: MOR240-1, GA_x6K02T2PAEV-9540823-9539888
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258408
HGNC: HGNC:8294
Homologene: 64870
Capsl
Name: calcyphosine-like
Synonyms: 1700028N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 75568
VEGA: 15
Homologene: 16959
Slc30a9
Name: solute carrier family 30 (zinc transporter), member 9
Synonyms: GAC63, 2310024J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 109108
HGNC: HGNC:1329
Homologene: 4627
Vezt
Name: vezatin, adherens junctions transmembrane protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215008
Homologene: 9739
Klk1b27
Name: kallikrein 1-related peptidase b27
Synonyms: mGK-27, Klk27, Klk21l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16619
HGNC: HGNC:6364
Homologene: 68141
Zswim2
Name: zinc finger SWIM-type containing 2
Synonyms: MEX, 1700025P14Rik, 4933437F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71861
Homologene: 32689
Pcyox1
Name: prenylcysteine oxidase 1
Synonyms: 1200015P13Rik, Pcly, PCL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 66881
Homologene: 9458
Ttc30a1
Name: tetratricopeptide repeat domain 30A1
Synonyms: 4930506L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 78802
Homologene: 136638
Olfr159
Name: olfactory receptor 159
Synonyms: Olfr37e, mOR37e, GA_x6K02T2N78B-16165641-16166600, MOR262-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 29849
Homologene: 128097
Tbc1d24
Name: TBC1 domain family, member 24
Synonyms: C530046L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224617
Homologene: 27469
Gm7356
Name: predicted gene 7356
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 664821
Homologene: 133217
D8Ertd82e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 67,172,755 bp
  • A to G, chromosome 1 at 139,423,659 bp
  • A to G, chromosome 2 at 31,420,309 bp
  • A to G, chromosome 2 at 37,473,602 bp
  • T to A, chromosome 2 at 68,662,424 bp
  • T to C, chromosome 2 at 75,980,777 bp
  • C to A, chromosome 2 at 83,915,688 bp
  • A to G, chromosome 3 at 141,211,696 bp
  • T to C, chromosome 4 at 43,770,063 bp
  • T to A, chromosome 4 at 65,297,408 bp
  • T to A, chromosome 4 at 74,404,969 bp
  • A to T, chromosome 5 at 52,756,905 bp
  • A to T, chromosome 5 at 63,804,800 bp
  • C to A, chromosome 5 at 64,333,433 bp
  • A to G, chromosome 5 at 67,342,117 bp
  • T to A, chromosome 5 at 147,303,234 bp
  • T to A, chromosome 6 at 86,392,182 bp
  • T to C, chromosome 7 at 19,377,970 bp
  • T to A, chromosome 7 at 44,055,690 bp
  • A to G, chromosome 7 at 44,904,395 bp
  • T to C, chromosome 7 at 45,615,227 bp
  • A to G, chromosome 7 at 107,955,169 bp
  • G to T, chromosome 7 at 126,703,080 bp
  • C to T, chromosome 8 at 27,406,746 bp
  • A to T, chromosome 8 at 36,104,183 bp
  • A to G, chromosome 8 at 90,978,887 bp
  • A to G, chromosome 9 at 32,256,979 bp
  • A to C, chromosome 9 at 109,381,682 bp
  • A to C, chromosome 10 at 94,000,474 bp
  • A to T, chromosome 11 at 87,893,807 bp
  • A to G, chromosome 11 at 100,903,743 bp
  • T to C, chromosome 13 at 28,145,482 bp
  • G to T, chromosome 14 at 60,378,782 bp
  • A to G, chromosome 14 at 68,642,062 bp
  • A to G, chromosome 15 at 9,461,788 bp
  • A to G, chromosome 15 at 51,799,276 bp
  • A to T, chromosome 16 at 46,117,986 bp
  • A to G, chromosome 17 at 14,000,739 bp
  • A to T, chromosome 17 at 24,183,787 bp
  • T to C, chromosome 19 at 13,585,417 bp
  • T to C, chromosome 19 at 44,535,764 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6002 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044181-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.