Strain Name:
C57BL/6J-MtgxR6008Btlr/Mmmh
Stock Number:
044185-MU
Citation ID:
RRID:MMRRC_044185-MU
Other Names:
R6008 (G1)
Major Collection:

Gene Information

Edn3
Name: endothelin 3
Synonyms: 114CH19, 114-CH19, tmgc48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13616
HGNC: HGNC:3178
Homologene: 88
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 1110013E22Rik, 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Pum1
Name: pumilio RNA-binding family member 1
Synonyms: Pumm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 80912
Homologene: 22830
Phf21a
Name: PHD finger protein 21A
Synonyms: 80kDa, Braf35/HDAC complex (Bhc), PFTF1, Bhc80, D030065N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192285
Homologene: 9597
Hmgn3
Name: high mobility group nucleosomal binding domain 3
Synonyms: 1110002A15Rik, TRIP7, HMGN3b, HMGN3a, 6330514M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 94353
Kpna4
Name: karyopherin (importin) alpha 4
Synonyms: IPOA3, 1110058D08Rik, importin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16649
HGNC: HGNC:6397
Homologene: 20521
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75786
Homologene: 8844
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Abcc4
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Synonyms: D630049P08Rik, MOAT-B, MRP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239273
VEGA: 14
HGNC: HGNC:55
Homologene: 74563
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Bard1
Name: BRCA1 associated RING domain 1
Synonyms: ENSMUSG00000060893, ENSMUSG00000073653
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12021
HGNC: HGNC:952
Homologene: 400
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Golga1
Name: golgi autoantigen, golgin subfamily a, 1
Synonyms: golgin-97, 0710001G09Rik, 2210418B03Rik, Golgi97, awag
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76899
HGNC: HGNC:4424
Homologene: 68223
Afap1
Name: actin filament associated protein 1
Synonyms: 9630044L16Rik, 2600003E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70292
Homologene: 11009
Phf11d
Name: PHD finger protein 11D
Synonyms: D14Ertd668e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219132
Homologene: 87807
Prkcq
Name: protein kinase C, theta
Synonyms: PKC-0, Pkcq, A130035A12Rik, PKC-theta, PKC theta, PKCtheta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18761
HGNC: HGNC:9410
Homologene: 21263
Zzz3
Name: zinc finger, ZZ domain containing 3
Synonyms: 3110065C23Rik, 6430567E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108946
Homologene: 9182
Erf
Name: Ets2 repressor factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13875
HGNC: HGNC:3444
Homologene: 68516
Btnl9
Name: butyrophilin-like 9
Synonyms: D330012D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237754
Homologene: 68540
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Map3k2
Name: mitogen-activated protein kinase kinase kinase 2
Synonyms: Mekk2, MEK kinase 2, 9630061B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 26405
VEGA: 18
HGNC: HGNC:6854
Homologene: 74576
Taf6l
Name: TATA-box binding protein associated factor 6 like
Synonyms: PAF65A, C530024J06Rik, 2810417N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225895
Homologene: 4728
Zfp988
Name: zinc finger protein 988
Synonyms: Gm13151
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: Ic, FIC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
C1rl
Name: complement component 1, r subcomponent-like
Synonyms: C1r-LP, C1rl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232371
Homologene: 9559
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Csn1s1
Name: casein alpha s1
Synonyms: Csna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12990
HGNC: HGNC:2445
Mroh4
Name: maestro heat-like repeat family member 4
Synonyms: 1700016M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69439
Homologene: 72545
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr5, Jr4, ZIZ3, 9330153B10Rik, A630054M16Rik, Zizimin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210293
Homologene: 45952
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 629499
Homologene: 51864
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-1, Aox-2, Aox2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74978
Homologene: 46007
Gm7247
Name: predicted gene 7247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 638695
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: D330001F17Rik, Heatr7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223658
Homologene: 44882
Ppp1r3b
Name: protein phosphatase 1, regulatory subunit 3B
Synonyms: GL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244416
Homologene: 11615
Dnai2
Name: dynein axonemal intermediate chain 2
Synonyms: C030015H18Rik, Dnaic2, b2b3405Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432611
Homologene: 11311
Pramel30
Name: PRAME like 30
Synonyms: Gm13128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 626995
Homologene: 129642
Tubb1
Name: tubulin, beta 1 class VI
Synonyms: 2810484G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545486
Homologene: 69474
Dennd3
Name: DENN/MADD domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105841
Homologene: 28254
Plekhh3
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217198
Homologene: 11787
Iftap
Name: intraflagellar transport associated protein
Synonyms: NWC, B230118H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68170
Homologene: 16348
Scgb2b27
Name: secretoglobin, family 2B, member 27
Synonyms: C2a, Abpb, Scgb2b5, Abpbg27, Abpbg5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233099
Homologene: 83171
Socs4
Name: suppressor of cytokine signaling 4
Synonyms: 3110032M18Rik, Socs7, A730004F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67296
Homologene: 15442
Ear2
Name: eosinophil-associated, ribonuclease A family, member 2
Synonyms: eosinophil-derived neurotoxin, liver, Rnase2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13587
Homologene: 40596
Ctnna2
Name: catenin (cadherin associated protein), alpha 2
Synonyms: alpha(N)-catenin, alpha N-catenin, Catna, chp, Catna2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12386
HGNC: HGNC:2510
Homologene: 68394
Sel1l2
Name: sel-1 suppressor of lin-12-like 2 (C. elegans)
Synonyms: LOC228684
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228684
Homologene: 16802
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627814
Homologene: 129678
Olfr559
Name: olfactory receptor 559
Synonyms: GA_x6K02T2PBJ9-5441154-5440198, MOR11-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259116
Homologene: 74124
Acot3
Name: acyl-CoA thioesterase 3
Synonyms: PTE-Ia, Pte2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 171281
Homologene: 134585
Ifna9
Name: interferon alpha 9
Synonyms: Ifa9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15972
HGNC: HGNC:5425
Homologene: 68536
Gm14548
Name: predicted gene 14548
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100038909
HGNC: HGNC:6607
Homologene: 134028
9530077C05Rik
Name: RIKEN cDNA 9530077C05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68283
VEGA: 9
Homologene: 19280
Esp34
Name: exocrine gland secreted peptide 34
Synonyms: Gm20410
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100126773
Tas2r107
Name: taste receptor, type 2, member 107
Synonyms: T2R07, Tas2r7, T2R4, STC 5-1, mGR06, mt2r43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387342
Homologene: 137369
Gsg1l2
Name: GSG1-like 2
Synonyms: Gm12302
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544792
Homologene: 132038
Spdye4c
Name: speedy/RINGO cell cycle regulator family, member E4C
Synonyms: LOC241634, Gm355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241634
Homologene: 78093
Mab21l1
Name: mab-21-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17116
HGNC: HGNC:6757
Homologene: 36183
Sys1
Name: SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
Synonyms: 2610042O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66460
Homologene: 43135
Gpr17
Name: G protein-coupled receptor 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 574402
HGNC: HGNC:4471
Homologene: 83191
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 58,077,513 bp
  • C to A, chromosome 1 at 71,030,750 bp
  • T to C, chromosome 1 at 80,606,173 bp
  • A to G, chromosome 2 at 11,256,286 bp
  • A to G, chromosome 2 at 39,047,087 bp
  • T to A, chromosome 2 at 91,562,989 bp
  • C to T, chromosome 2 at 92,351,752 bp
  • A to T, chromosome 2 at 101,583,553 bp
  • A to T, chromosome 2 at 128,596,633 bp
  • T to A, chromosome 2 at 140,244,105 bp
  • A to G, chromosome 2 at 157,253,064 bp
  • T to C, chromosome 2 at 164,464,587 bp
  • T to C, chromosome 2 at 165,842,787 bp
  • T to A, chromosome 2 at 174,457,774 bp
  • A to G, chromosome 2 at 174,779,732 bp
  • G to T, chromosome 3 at 55,783,097 bp
  • T to C, chromosome 3 at 69,126,733 bp
  • T to C, chromosome 3 at 152,428,151 bp
  • T to A, chromosome 4 at 32,741,073 bp
  • A to T, chromosome 4 at 88,592,363 bp
  • T to C, chromosome 4 at 130,768,847 bp
  • C to T, chromosome 4 at 144,331,207 bp
  • A to G, chromosome 4 at 147,331,802 bp
  • C to A, chromosome 5 at 31,069,112 bp
  • T to G, chromosome 5 at 35,997,551 bp
  • T to C, chromosome 5 at 87,678,085 bp
  • A to G, chromosome 6 at 76,915,828 bp
  • A to G, chromosome 6 at 124,493,188 bp
  • A to G, chromosome 6 at 131,659,912 bp
  • G to T, chromosome 7 at 3,894,600 bp
  • C to T, chromosome 7 at 25,245,616 bp
  • T to C, chromosome 7 at 34,012,136 bp
  • T to A, chromosome 7 at 102,724,367 bp
  • G to A, chromosome 7 at 135,697,429 bp
  • G to A, chromosome 8 at 35,384,201 bp
  • A to C, chromosome 8 at 110,599,085 bp
  • G to A, chromosome 9 at 22,424,126 bp
  • T to A, chromosome 9 at 83,112,231 bp
  • A to G, chromosome 10 at 103,170,464 bp
  • C to A, chromosome 11 at 49,182,965 bp
  • T to A, chromosome 11 at 67,774,711 bp
  • T to C, chromosome 11 at 101,164,765 bp
  • A to G, chromosome 11 at 114,752,990 bp
  • T to A, chromosome 12 at 84,057,086 bp
  • T to A, chromosome 14 at 44,103,089 bp
  • T to G, chromosome 14 at 47,290,161 bp
  • C to T, chromosome 14 at 51,364,348 bp
  • T to A, chromosome 14 at 59,365,449 bp
  • A to G, chromosome 14 at 118,490,566 bp
  • T to A, chromosome 15 at 73,567,080 bp
  • T to A, chromosome 15 at 74,625,472 bp
  • A to T, chromosome 15 at 76,451,357 bp
  • G to A, chromosome 17 at 20,540,719 bp
  • A to G, chromosome 17 at 38,554,227 bp
  • T to A, chromosome 17 at 84,436,634 bp
  • T to A, chromosome 18 at 31,947,477 bp
  • A to G, chromosome 18 at 32,203,051 bp
  • G to T, chromosome 18 at 64,577,616 bp
  • A to G, chromosome 19 at 4,739,278 bp
  • T to C, chromosome 19 at 8,778,166 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6008 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044185-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.