Strain Name:
C57BL/6J-MtgxR6050Btlr
Stock Number:
044218-MU
Citation ID:
RRID:MMRRC_044218-MU
Other Names:
R6050 (G1)
Major Collection:

Gene Information

Notch3
Name: notch 3
Synonyms: N3, hpbk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242022
Homologene: 18454
Ncam2
Name: neural cell adhesion molecule 2
Synonyms: RNCAM, R4B12 antigen, Ncam-2, Ocam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17968
HGNC: HGNC:7657
Homologene: 3336
Lias
Name: lipoic acid synthetase
Synonyms: MGC7254, mLip1, 4933425M12Rik, 2900022L22Rik, 7a5ex
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 79464
Homologene: 4997
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: 5033417D07Rik, BTF2, D5Ertd679e, 34kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230793
Homologene: 17144
Tbce
Name: tubulin-specific chaperone E
Synonyms: 2610206D02Rik, C530005D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70430
Homologene: 37744
Ttc5
Name: tetratricopeptide repeat domain 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219022
VEGA: 14
Homologene: 14397
Prcc
Name: papillary renal cell carcinoma (translocation-associated)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 94315
HGNC: HGNC:9343
Homologene: 38120
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: A20-binding inhibitor of NF-kappa B activation, ABIN1, VAN, Nef
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57783
Homologene: 31355
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: A930036P18Rik, A630086M08Rik, Rbm16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106583
VEGA: 17
Homologene: 8928
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: ENSMUSG00000075261, CAMDI, 2610301F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545428
Homologene: 52149
Oga
Name: O-GlcNAcase
Synonyms: Hy5, 2810009A20Rik, 4833427O07Rik, 5830447M11Rik, Mgea5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76055
VEGA: 19
HGNC: HGNC:7056
Homologene: 8154
Clhc1
Name: clathrin heavy chain linker domain containing 1
Synonyms: 1700034F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73324
Homologene: 17569
Gzf1
Name: GDNF-inducible zinc finger protein 1
Synonyms: 8430437G08Rik, Zfp336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74533
Homologene: 11200
Cmtr1
Name: cap methyltransferase 1
Synonyms: 1300018I05Rik, Ftsjd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74157
Homologene: 9003
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Sec14l2
Name: SEC14-like lipid binding 2
Synonyms: 1300013M05Rik, tap, Spf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67815
Homologene: 8245
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, crash, Adgrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Duox1
Name: dual oxidase 1
Synonyms: LNOX1, 9930101G15Rik, NOXEF1, THOX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Ak9
Name: adenylate kinase 9
Synonyms: LOC215946, Akd2, Gm7127, Akd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 633979
Homologene: 67934
Abca8b
Name: ATP-binding cassette, sub-family A (ABC1), member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Mrps21
Name: mitochondrial ribosomal protein S21
Synonyms: 1810031B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66292
Homologene: 45365
Aox3
Name: aldehyde oxidase 3
Synonyms: AOH1, 1200011D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71724
Homologene: 90899
Gm16432
Name: predicted gene 16432
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Ift140
Name: intraflagellar transport 140
Synonyms: Wdtc2, Tce5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106633
Homologene: 40979
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243628
Homologene: 135915
Fcf1
Name: FCF1 rRNA processing protein
Synonyms: 1110008B24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73736
Homologene: 5706
Zfp780b
Name: zinc finger protein 780B
Synonyms: B230208L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338354
Homologene: 85969
BC048679
Name: cDNA sequence BC048679
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210321
Homologene: 130364
Mn1
Name: meningioma 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 433938
HGNC: HGNC:7180
Homologene: 37620
Psg25
Name: pregnancy-specific glycoprotein 25
Synonyms: cea13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114868
Homologene: 110989
Bbs2
Name: Bardet-Biedl syndrome 2 (human)
Synonyms: 2410125H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
Rfk
Name: riboflavin kinase
Synonyms: ATP:riboflavin 5'-phosphotransferase, flavokinase, 0610038L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54391
Homologene: 115690
Smtnl1
Name: smoothelin-like 1
Synonyms: 1110030K22Rik, Chasm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68678
Homologene: 11488
Pcbp4
Name: poly(rC) binding protein 4
Synonyms: AlphaCP-4, 1200003L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 59092
HGNC: HGNC:8652
Homologene: 56926
Trbv19
Name: T cell receptor beta, variable 19
Synonyms: Tcrb-V6, Gm16780
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100124684
Ovol3
Name: ovo like zinc finger 3
Synonyms: LOC381867, movo3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381867
Homologene: 35553
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 54,406,070 bp
  • T to C, chromosome 1 at 58,180,655 bp
  • G to A, chromosome 1 at 178,103,924 bp
  • T to C, chromosome 1 at 188,957,324 bp
  • G to T, chromosome 2 at 77,011,731 bp
  • A to G, chromosome 2 at 84,811,453 bp
  • C to T, chromosome 2 at 122,319,475 bp
  • G to A, chromosome 2 at 148,684,238 bp
  • T to C, chromosome 3 at 53,653,012 bp
  • G to A, chromosome 3 at 87,869,884 bp
  • C to T, chromosome 3 at 95,862,888 bp
  • A to G, chromosome 4 at 133,065,891 bp
  • A to G, chromosome 5 at 65,393,972 bp
  • A to G, chromosome 5 at 111,419,397 bp
  • C to T, chromosome 5 at 124,584,297 bp
  • A to G, chromosome 6 at 41,179,010 bp
  • T to C, chromosome 6 at 123,815,732 bp
  • A to G, chromosome 7 at 18,526,478 bp
  • A to T, chromosome 7 at 27,964,302 bp
  • T to A, chromosome 7 at 30,234,394 bp
  • T to C, chromosome 7 at 81,495,591 bp
  • T to A, chromosome 8 at 94,092,532 bp
  • T to C, chromosome 9 at 106,462,223 bp
  • A to G, chromosome 10 at 41,389,112 bp
  • T to C, chromosome 11 at 4,111,477 bp
  • A to G, chromosome 11 at 29,561,397 bp
  • G to A, chromosome 11 at 54,917,877 bp
  • C to T, chromosome 11 at 69,458,920 bp
  • C to A, chromosome 11 at 109,977,813 bp
  • G to A, chromosome 12 at 84,982,243 bp
  • T to C, chromosome 12 at 85,240,846 bp
  • C to T, chromosome 13 at 13,998,434 bp
  • T to A, chromosome 14 at 50,773,287 bp
  • T to C, chromosome 15 at 76,188,258 bp
  • T to C, chromosome 15 at 85,930,611 bp
  • C to T, chromosome 16 at 81,443,166 bp
  • C to T, chromosome 17 at 3,168,108 bp
  • C to T, chromosome 17 at 25,091,005 bp
  • G to T, chromosome 17 at 29,682,134 bp
  • T to C, chromosome 17 at 32,143,527 bp
  • T to C, chromosome 17 at 49,486,502 bp
  • C to T, chromosome 19 at 17,399,532 bp
  • A to C, chromosome 19 at 45,765,480 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6050 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044218-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.