Strain Name:
C57BL/6J-MtgxR6074Btlr
Stock Number:
044235-MU
Citation ID:
RRID:MMRRC_044235-MU
Other Names:
R6074 (G1)
Major Collection:

Gene Information

Amigo1
Name: adhesion molecule with Ig like domain 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229715
Homologene: 46421
Kcna6
Name: potassium voltage-gated channel, shaker-related, subfamily, member 6
Synonyms: Kv1.6, MK1.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16494
HGNC: HGNC:6225
Homologene: 1684
Ip6k1
Name: inositol hexaphosphate kinase 1
Synonyms: InsP6k1, Ihpk1, 1200016D08Rik, InsP6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 27399
Homologene: 56602
Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268
Slc25a12
Name: solute carrier family 25 (mitochondrial carrier, Aralar), member 12
Synonyms: B230107K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78830
Homologene: 48235
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 6430526O11Rik, 2900074J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237898
Homologene: 13066
Auts2
Name: autism susceptibility candidate 2
Synonyms: 2700063G02Rik, A730011F23Rik, D830032G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319974
Homologene: 22907
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Ccnt1
Name: cyclin T1
Synonyms: 2810478G24Rik, CycT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12455
HGNC: HGNC:1599
Homologene: 947
Osbpl11
Name: oxysterol binding protein-like 11
Synonyms: ORP-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106326
Homologene: 23385
Eif2d
Name: eukaryotic translation initiation factor 2D
Synonyms: Lgtn, D1Ertd5e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16865
HGNC: HGNC:6583
Homologene: 38244
Cdhr1
Name: cadherin-related family member 1
Synonyms: Pcdh21, Prcad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
Lss
Name: lanosterol synthase
Synonyms: Osc, 2810025N20Rik, D10Ertd116e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16987
HGNC: HGNC:6708
Homologene: 37408
Lratd1
Name: LRAT domain containing 1
Synonyms: 2310003N02Rik, 4731402F03Rik, Fam84a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 105005
VEGA: 12
Homologene: 12576
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Plc, perlecan, per, Pcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: C030002J06Rik, 4930429G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 78787
Homologene: 90902
Cep170b
Name: centrosomal protein 170B
Synonyms: AW555464
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217882
VEGA: 12
Homologene: 46165
Galnt12
Name: polypeptide N-acetylgalactosaminyltransferase 12
Synonyms: A630062B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230145
Homologene: 11637
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Schnurri-2, Gm20114, Shn-2, MIBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Glp2r
Name: glucagon-like peptide 2 receptor
Synonyms: 9530092J08Rik, GLP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 93896
HGNC: HGNC:4325
Homologene: 3132
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Tpo
Name: thyroid peroxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22018
Homologene: 461
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: Heatr7b1, OTTMUSG00000020804, ENSMUSG00000044873
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: X83337, ESTM15, 1810073P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75607
Homologene: 19155
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Orp1, oxygen-regulated protein 1, Dcdc3, Rp1h, mG145
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Zfp770
Name: zinc finger protein 770
Synonyms: 6430601A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228491
Homologene: 82354
Slc39a12
Name: solute carrier family 39 (zinc transporter), member 12
Synonyms: LOC277468
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277468
Homologene: 17654
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 624845
Homologene: 83483
Htatip2
Name: HIV-1 Tat interactive protein 2
Synonyms: TIP30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53415
Homologene: 4676
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: 5530401I02Rik, 9530025L16Rik, 4632417D23Rik, LOC268884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77446
Homologene: 35276
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432486
Homologene: 32576
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: B0AT1, 4632401C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74338
Homologene: 52819
Zfp212
Name: Zinc finger protein 212
Synonyms: Znf212
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232784
Homologene: 8170
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231589
Homologene: 129606
Samd5
Name: sterile alpha motif domain containing 5
Synonyms: E130306M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320825
Homologene: 37106
Zfp661
Name: zinc finger protein 661
Synonyms: 2810405K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72180
Homologene: 23275
Thumpd3
Name: THUMP domain containing 3
Synonyms: Gtrosa26as
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14911
Homologene: 7351
Xkr6
Name: X-linked Kx blood group related 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219149
Homologene: 18287
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320405
Homologene: 23060
Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Synonyms: Grfbeta, Grf1, CDC25Mm, CDC25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19417
HGNC: HGNC:9875
Homologene: 74972
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Krc, Schnurri-3, 2900056N03Rik, E030045D18Rik, Shn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16656
Homologene: 7803
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58909
Homologene: 135847
Lgi2
Name: leucine-rich repeat LGI family, member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 246316
Homologene: 10048
Ccdc74a
Name: coiled-coil domain containing 74A
Synonyms: 2310015A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 72315
Homologene: 82592
Ceacam3
Name: carcinoembryonic antigen-related cell adhesion molecule 3
Synonyms: cea12, EG384557, Psg24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384557
Homologene: 86971
Zfp647
Name: zinc finger protein 647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239546
VEGA: 15
Homologene: 27805
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 171580
Homologene: 11246
Olfr16
Name: olfactory receptor 16
Synonyms: GA_x6K02T2R7CC-893157-892228, MOR267-13, MOR23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18313
Homologene: 7460
Tpra1
Name: transmembrane protein, adipocyte asscociated 1
Synonyms: Gpr175, 40kDa, Tpra40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 24100
Homologene: 40799
Txnrd2
Name: thioredoxin reductase 2
Synonyms: TR3, ESTM573010, TR beta, TGR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 26462
Homologene: 4701
Olfr1198
Name: olfactory receptor 1198
Synonyms: MOR225-13, GA_x6K02T2Q125-50221692-50220766
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404330
Homologene: 138634
Tmem74
Name: transmembrane protein 74
Synonyms: B230382K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239408
VEGA: 15
Homologene: 17684
Olfr1416
Name: olfactory receptor 1416
Synonyms: MOR103-3, GA_x6K02T2R7CC-81277975-81278913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 259040
Homologene: 17472
Nat8f4
Name: N-acetyltransferase 8 (GCN5-related) family member 4
Synonyms: 1700019G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75541
Homologene: 136346
Timd2
Name: T cell immunoglobulin and mucin domain containing 2
Synonyms: TIM-2, Tim2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171284
Homologene: 82236
Camk2b
Name: calcium/calmodulin-dependent protein kinase II, beta
Synonyms: CaMK II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12323
HGNC: HGNC:1461
Homologene: 111050
Pea15a
Name: phosphoprotein enriched in astrocytes 15A
Synonyms: Mat1, PEA-15, Pea15, Pkcs15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18611
HGNC: HGNC:8822
Homologene: 7884
Ighv1-75
Name: immunoglobulin heavy variable 1-75
Synonyms: Gm16811
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 622728
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,345,379 bp
  • T to A, chromosome 1 at 24,526,483 bp
  • A to G, chromosome 1 at 88,258,664 bp
  • G to A, chromosome 1 at 92,479,775 bp
  • T to A, chromosome 1 at 131,166,342 bp
  • C to T, chromosome 1 at 172,199,185 bp
  • T to A, chromosome 1 at 172,957,378 bp
  • C to T, chromosome 2 at 14,407,479 bp
  • A to G, chromosome 2 at 71,276,454 bp
  • A to C, chromosome 2 at 88,746,222 bp
  • A to G, chromosome 2 at 114,196,389 bp
  • A to G, chromosome 2 at 127,577,873 bp
  • T to A, chromosome 3 at 108,191,693 bp
  • T to A, chromosome 4 at 47,112,405 bp
  • T to C, chromosome 4 at 113,805,200 bp
  • T to C, chromosome 4 at 120,097,694 bp
  • A to G, chromosome 4 at 137,540,735 bp
  • A to T, chromosome 5 at 52,546,642 bp
  • A to G, chromosome 5 at 109,174,301 bp
  • G to T, chromosome 5 at 131,476,989 bp
  • C to A, chromosome 6 at 23,626,671 bp
  • T to A, chromosome 6 at 47,927,052 bp
  • A to G, chromosome 6 at 58,989,738 bp
  • A to G, chromosome 6 at 85,901,187 bp
  • T to A, chromosome 6 at 88,911,937 bp
  • A to G, chromosome 6 at 113,060,010 bp
  • A to G, chromosome 6 at 126,739,279 bp
  • C to T, chromosome 7 at 17,151,559 bp
  • A to G, chromosome 7 at 49,772,574 bp
  • T to A, chromosome 7 at 130,625,435 bp
  • A to G, chromosome 9 at 89,953,915 bp
  • A to G, chromosome 9 at 108,024,109 bp
  • T to A, chromosome 10 at 9,674,590 bp
  • T to A, chromosome 10 at 14,131,741 bp
  • T to C, chromosome 10 at 41,486,065 bp
  • T to A, chromosome 10 at 76,543,859 bp
  • T to A, chromosome 10 at 79,396,543 bp
  • C to T, chromosome 10 at 88,433,078 bp
  • G to T, chromosome 11 at 5,989,635 bp
  • C to T, chromosome 11 at 46,687,172 bp
  • A to G, chromosome 11 at 67,746,814 bp
  • A to G, chromosome 11 at 84,994,573 bp
  • G to A, chromosome 11 at 119,284,186 bp
  • G to A, chromosome 12 at 14,150,511 bp
  • A to G, chromosome 12 at 30,078,187 bp
  • A to G, chromosome 12 at 111,832,402 bp
  • T to C, chromosome 12 at 112,744,155 bp
  • T to C, chromosome 12 at 115,834,387 bp
  • A to T, chromosome 13 at 49,051,399 bp
  • T to C, chromosome 13 at 73,689,763 bp
  • C to A, chromosome 14 at 20,552,099 bp
  • C to T, chromosome 14 at 33,083,639 bp
  • T to C, chromosome 14 at 37,079,643 bp
  • T to G, chromosome 14 at 63,607,070 bp
  • A to G, chromosome 15 at 43,866,738 bp
  • G to A, chromosome 15 at 76,912,085 bp
  • T to A, chromosome 15 at 90,980,892 bp
  • A to C, chromosome 15 at 98,543,324 bp
  • C to A, chromosome 16 at 17,646,727 bp
  • T to C, chromosome 16 at 18,437,547 bp
  • C to T, chromosome 16 at 23,000,596 bp
  • T to A, chromosome 16 at 33,209,965 bp
  • C to T, chromosome 16 at 33,727,203 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6074 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044235-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.