Strain Name:
C57BL/6J-MtgxR6076Btlr/Mmmh
Stock Number:
044237-MU
Citation ID:
RRID:MMRRC_044237-MU
Other Names:
R6076 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: PC1, polycystin-1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Synonyms: SDI1, Waf1, P21, p21WAF, mda6, CDKI, Cdkn1, p21Cip1, CIP1, p21WAF1/CIP1, CAP20
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12575
HGNC: HGNC:1784
Homologene: 333
Rest
Name: RE1-silencing transcription factor
Synonyms: NRSF, 2610008J04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Sema3e
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms: Semah
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20349
Homologene: 8247
Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Mapk8
Name: mitogen-activated protein kinase 8
Synonyms: Prkm8, JNK1, c-Jun N-terminal kinase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 26419
HGNC: HGNC:6881
Homologene: 56760
Cep70
Name: centrosomal protein 70
Synonyms: C030018L16Rik, 6720484E09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68121
Homologene: 11387
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, SBP2, 2810012K13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Synonyms: sEP, sEH, Eph2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13850
VEGA: 14
HGNC: HGNC:3402
Homologene: 37558
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, Depdc2, 6230420N16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Csde1
Name: cold shock domain containing E1, RNA binding
Synonyms: D3Jfr1, unr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229663
Homologene: 5179
Wdr7
Name: WD repeat domain 7
Synonyms: TGF-beta resistance associated gene, TRAG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: 5430437K10Rik, BRIT1, D030046N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Ank3
Name: ankyrin 3, epithelial
Synonyms: AnkG, Ank-3, Ankyrin-G, 2900054D09Rik, Ankyrin-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Rasa2
Name: RAS p21 protein activator 2
Synonyms: 5430433H21Rik, GAP1m
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114713
HGNC: HGNC:9872
Homologene: 4745
Grid2ip
Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms: delphilin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 170935
Homologene: 15781
Hpcal4
Name: hippocalcin-like 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170638
Homologene: 9441
Epha6
Name: Eph receptor A6
Synonyms: m-ehk2, Ehk2, Hek12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13840
Homologene: 56396
Wdr36
Name: WD repeat domain 36
Synonyms: 5730444A13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225348
VEGA: 18
Homologene: 6536
Nceh1
Name: neutral cholesterol ester hydrolase 1
Synonyms: Aadacl1, mKIAA1363, B230106I24Rik, CPO-BP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320024
Homologene: 23251
Dlk1
Name: delta like non-canonical Notch ligand 1
Synonyms: Peg9, ZOG, SCP1, DlkI, FA1, pref-1, pG2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13386
HGNC: HGNC:2907
Homologene: 2846
Hspa1b
Name: heat shock protein 1B
Synonyms: Hsp70-1, Hsp70.1, HSP70B1, hsp68
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15511
HGNC: HGNC:5233
Homologene: 133785
Or1p1c
Name: olfactory receptor family 1 subfamily P member 1C
Synonyms: GA_x6K02T2P1NL-4415162-4416133, MOR133-1, Olfr406, Olfr406-ps
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258181
HGNC: HGNC:8222
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Atp6v0a1
Name: ATPase, H+ transporting, lysosomal V0 subunit A1
Synonyms: V-ATPase a1, Vpp1, Atp6n1, Atp6n1a, Vpp-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11975
HGNC: HGNC:865
Homologene: 3795
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: B430315C20Rik, Hisppd2a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 327655
Homologene: 49395
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
Lrrc15
Name: leucine rich repeat containing 15
Synonyms: 5430427N11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74488
Homologene: 26080
Fpr-rs4
Name: formyl peptide receptor, related sequence 4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14291
HGNC: HGNC:3827
Homologene: 130629
Cimip4
Name: ciliary microtubule inner protein 4
Synonyms: Tex33, 1700061J05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73376
VEGA: 15
Homologene: 18682
Noxa1
Name: NADPH oxidase activator 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241275
Homologene: 18156
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: B830014K08Rik, very-kind, VKIND, 2410012C07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Jchain
Name: immunoglobulin joining chain
Synonyms: Jch, J chain, Igj, 9530090F24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16069
HGNC: HGNC:5713
Homologene: 16958
Zfp945
Name: zinc finger protein 945
Synonyms: C730040L01Rik, A630033E08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240041
Homologene: 133214
Lrp8
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms: 4932703M08Rik, Lr8b, apoER2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16975
HGNC: HGNC:6700
Homologene: 31250
Slc6a17
Name: solute carrier family 6 (neurotransmitter transporter), member 17
Synonyms: D130012J15Rik, NTT4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229706
Homologene: 27775
Hspa14
Name: heat shock protein 14
Synonyms: HSP70L1, Hsp70-4, NST-1, 70kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50497
Homologene: 74307
Gimap1
Name: GTPase, IMAP family member 1
Synonyms: IAP38, imap, Imap38, 38kDa
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16205
Homologene: 7379
Mrps7
Name: mitchondrial ribosomal protein S7
Synonyms: MRP-S7, Rpms7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50529
Homologene: 9321
Ube2d4
Name: ubiquitin-conjugating enzyme E2D 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Smpd5
Name: sphingomyelin phosphodiesterase 5
Synonyms: Gm10345
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100503915
Homologene: 132205
Gm10784
Name: predicted pseudogene 10784
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100040099
VEGA: 13
C530025M09Rik
Name: RIKEN cDNA C530025M09 gene
Type: Gene
Species: Mouse
Chromosome: 2
Wbscr16
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,185,950 bp
  • A to T, chromosome 1 at 24,195,376 bp
  • C to T, chromosome 2 at 3,511,072 bp
  • A to T, chromosome 2 at 25,085,809 bp
  • C to T, chromosome 2 at 26,423,942 bp
  • T to C, chromosome 2 at 121,337,110 bp
  • T to C, chromosome 2 at 149,830,750 bp
  • A to C, chromosome 3 at 27,279,195 bp
  • G to A, chromosome 3 at 103,041,229 bp
  • A to G, chromosome 3 at 107,472,071 bp
  • G to T, chromosome 4 at 107,847,459 bp
  • C to A, chromosome 4 at 123,190,721 bp
  • A to G, chromosome 5 at 14,241,086 bp
  • A to G, chromosome 5 at 77,282,974 bp
  • G to T, chromosome 5 at 88,527,772 bp
  • A to G, chromosome 5 at 134,169,328 bp
  • G to C, chromosome 5 at 143,387,375 bp
  • C to G, chromosome 5 at 150,953,001 bp
  • C to T, chromosome 6 at 48,742,587 bp
  • A to G, chromosome 7 at 139,902,038 bp
  • C to T, chromosome 8 at 18,631,999 bp
  • A to G, chromosome 9 at 67,911,602 bp
  • T to C, chromosome 9 at 96,545,646 bp
  • T to A, chromosome 9 at 99,298,505 bp
  • G to A, chromosome 10 at 70,002,565 bp
  • T to C, chromosome 11 at 74,270,262 bp
  • T to C, chromosome 11 at 75,167,328 bp
  • T to A, chromosome 11 at 101,055,060 bp
  • T to C, chromosome 11 at 115,604,887 bp
  • A to G, chromosome 12 at 109,459,969 bp
  • T to C, chromosome 13 at 49,945,274 bp
  • C to A, chromosome 13 at 51,679,777 bp
  • A to G, chromosome 14 at 33,390,293 bp
  • A to T, chromosome 14 at 61,204,536 bp
  • A to G, chromosome 14 at 66,092,848 bp
  • T to A, chromosome 15 at 58,847,143 bp
  • C to A, chromosome 15 at 76,294,892 bp
  • T to C, chromosome 15 at 78,386,227 bp
  • T to A, chromosome 16 at 30,272,988 bp
  • A to T, chromosome 16 at 60,205,710 bp
  • A to G, chromosome 17 at 18,022,055 bp
  • G to A, chromosome 17 at 22,851,458 bp
  • G to A, chromosome 17 at 24,581,030 bp
  • A to G, chromosome 17 at 29,099,358 bp
  • G to A, chromosome 17 at 34,957,497 bp
  • C to A, chromosome 18 at 32,846,945 bp
  • T to A, chromosome 18 at 63,739,277 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6076 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044237-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.