Strain Name:
C57BL/6J-MtgxR6081Btlr
Stock Number:
044240-MU
Citation ID:
RRID:MMRRC_044240-MU
Other Names:
R6081 (G1)
Major Collection:

Gene Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330286
Homologene: 19782
Adcy9
Name: adenylate cyclase 9
Synonyms: ACtp10, D16Wsu65e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226747
Homologene: 9142
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, Ankyrin-G, Ankyrin-3, 2900054D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, Emv66, par
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Dhx32
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 32
Synonyms: Ddx32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101437
Homologene: 56798
4930522L14Rik
Name: RIKEN cDNA 4930522L14 gene
Synonyms: Gm42152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100041734
Susd1
Name: sushi domain containing 1
Synonyms: Gm12528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 634731
Homologene: 11204
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: CC1, Min
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Anxa5
Name: annexin A5
Synonyms: annexin V, Anx5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11747
HGNC: HGNC:543
Homologene: 20312
Nav1
Name: neuron navigator 1
Synonyms: C230080M11Rik, steerin-1, POMFIL3, unc53H1, 9930003A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 215690
Homologene: 10719
Samd12
Name: sterile alpha motif domain containing 12
Synonyms: A830094I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 320679
Homologene: 35979
H2-T23
Name: histocompatibility 2, T region locus 23
Synonyms: T18c, T23b, Qed-1, Qa1, Qa-1, 37b, H-2T23, T18c(37), T23d, 37c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 15040
HGNC: HGNC:4962
Homologene: 134018
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E16Rik, Myospryn, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 76469
VEGA: 13
Homologene: 137367
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG620718, EG667069
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 667069
Homologene: 129754
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223825
VEGA: 15
Homologene: 128807
Cstf2t
Name: cleavage stimulation factor, 3' pre-RNA subunit 2, tau
Synonyms: 64kDa, tCstF-64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 83410
VEGA: 19
Homologene: 80230
Speer4a
Name: spermatogenesis associated glutamate (E)-rich protein 4A
Synonyms: 1700027N01Rik, SPEER-4A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75657
Homologene: 69402
Sec16b
Name: SEC16 homolog B (S. cerevisiae)
Synonyms: Lztr2, Rgpr-p117, Rgpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 89867
Homologene: 13227
Gpr180
Name: G protein-coupled receptor 180
Synonyms: E130016I23Rik, ITR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 58245
VEGA: 14
Homologene: 32506
Mcm8
Name: minichromosome maintenance 8 homologous recombination repair factor
Synonyms: 5730432L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66634
Homologene: 12001
Dppa3
Name: developmental pluripotency-associated 3
Synonyms: stella, 2410075G02Rik, PGC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 73708
Homologene: 138189
4930556J24Rik
Name: RIKEN cDNA 4930556J24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Btnl4
Name: butyrophilin-like 4
Synonyms: Btn3a3, NG11, EG632126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 632126
Homologene: 106849
Gzme
Name: granzyme E
Synonyms: MCSP-2, CCP3, Ctla6, Ctla-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 14942
VEGA: 14
Homologene: 133275
Rnaset2b
Name: ribonuclease T2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 68195
VEGA: 17
Homologene: 31190
Diras2
Name: DIRAS family, GTP-binding RAS-like 2
Synonyms: 2900052J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 68203
VEGA: 13
Homologene: 56777
Krtap5-3
Name: keratin associated protein 5-3
Synonyms: A030007E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 77215
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 135,470,822 bp
  • T to C, chromosome 1 at 157,560,754 bp
  • G to T, chromosome 1 at 179,781,672 bp
  • T to C, chromosome 1 at 184,727,697 bp
  • G to T, chromosome 2 at 132,828,083 bp
  • C to T, chromosome 3 at 36,465,287 bp
  • C to T, chromosome 3 at 64,556,532 bp
  • C to A, chromosome 4 at 59,411,359 bp
  • A to T, chromosome 5 at 26,034,962 bp
  • A to T, chromosome 5 at 109,739,231 bp
  • A to T, chromosome 6 at 38,142,698 bp
  • T to A, chromosome 6 at 122,629,972 bp
  • A to G, chromosome 7 at 133,722,212 bp
  • G to A, chromosome 7 at 142,201,486 bp
  • G to A, chromosome 10 at 70,002,565 bp
  • T to C, chromosome 11 at 3,938,140 bp
  • A to T, chromosome 11 at 21,999,406 bp
  • T to C, chromosome 13 at 52,508,145 bp
  • T to A, chromosome 13 at 93,144,513 bp
  • T to G, chromosome 14 at 56,118,307 bp
  • C to T, chromosome 14 at 118,153,674 bp
  • G to C, chromosome 15 at 4,944,377 bp
  • T to C, chromosome 15 at 53,719,678 bp
  • T to C, chromosome 16 at 4,294,681 bp
  • T to A, chromosome 17 at 6,988,794 bp
  • C to A, chromosome 17 at 34,474,236 bp
  • T to A, chromosome 17 at 36,031,815 bp
  • C to T, chromosome 18 at 34,290,111 bp
  • G to T, chromosome 18 at 67,421,259 bp
  • G to T, chromosome 19 at 31,083,123 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6081 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044240-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.