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Strain Name:
C57BL/6J-MtgxR6082Btlr/Mmmh
Stock Number:
044241-MU
Citation ID:
RRID:MMRRC_044241-MU
Other Names:
R6082 (G1)
Major Collection:

Strain Information

Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: Fadk, FAK, FRNK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Eif4e2
Name: eukaryotic translation initiation factor 4E member 2
Synonyms: D0H0S6743E, 2700069E09Rik, Eif4el3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26987
HGNC: HGNC:3293
Homologene: 128466
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107182
Homologene: 31978
Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Synonyms: PTP2C, PTP1D, SH-PTP2, SHP-2, Syp, Shp2, SH2 domain-containing protein tyrosine phosphatase-2, 2700084A17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19247
HGNC: HGNC:9644
Homologene: 2122
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Eif3a
Name: eukaryotic translation initiation factor 3, subunit A
Synonyms: Csma, Eif3, A830012B05Rik, Eif3s10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13669
VEGA: 19
HGNC: HGNC:3271
Homologene: 2779
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 11,798,528 bp
  • G to T, chromosome 1 at 87,226,234 bp
  • A to G, chromosome 1 at 135,849,434 bp
  • T to C, chromosome 1 at 189,658,104 bp
  • C to T, chromosome 2 at 25,583,825 bp
  • A to C, chromosome 2 at 86,198,317 bp
  • T to C, chromosome 3 at 95,130,285 bp
  • A to T, chromosome 3 at 100,124,185 bp
  • G to A, chromosome 3 at 142,545,936 bp
  • A to G, chromosome 4 at 42,972,511 bp
  • T to C, chromosome 5 at 63,805,031 bp
  • C to T, chromosome 5 at 100,036,481 bp
  • T to C, chromosome 5 at 121,154,526 bp
  • T to C, chromosome 6 at 92,889,949 bp
  • A to T, chromosome 6 at 123,204,141 bp
  • A to C, chromosome 6 at 141,663,670 bp
  • A to G, chromosome 6 at 149,068,695 bp
  • G to A, chromosome 7 at 25,211,290 bp
  • T to A, chromosome 7 at 26,567,977 bp
  • T to C, chromosome 7 at 27,335,680 bp
  • T to A, chromosome 7 at 85,858,221 bp
  • A to G, chromosome 7 at 140,610,681 bp
  • C to A, chromosome 8 at 26,110,785 bp
  • A to T, chromosome 8 at 68,896,649 bp
  • C to A, chromosome 9 at 38,672,570 bp
  • T to C, chromosome 9 at 101,971,104 bp
  • C to A, chromosome 10 at 13,171,311 bp
  • A to G, chromosome 10 at 95,551,456 bp
  • A to G, chromosome 11 at 58,999,567 bp
  • T to C, chromosome 11 at 96,318,533 bp
  • C to T, chromosome 11 at 101,764,313 bp
  • G to A, chromosome 12 at 29,832,332 bp
  • T to C, chromosome 12 at 29,842,519 bp
  • T to A, chromosome 13 at 8,890,470 bp
  • A to G, chromosome 14 at 56,668,541 bp
  • A to T, chromosome 14 at 99,062,294 bp
  • A to T, chromosome 15 at 73,276,865 bp
  • A to G, chromosome 15 at 76,430,223 bp
  • GC to GCC, chromosome 15 at 89,374,364 bp
  • C to T, chromosome 15 at 98,456,766 bp
  • A to G, chromosome 15 at 100,645,148 bp
  • A to G, chromosome 17 at 71,349,719 bp
  • T to C, chromosome 18 at 38,301,670 bp
  • G to A, chromosome 18 at 58,968,774 bp
  • C to T, chromosome 19 at 36,983,542 bp
  • T to C, chromosome 19 at 60,772,130 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6082 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044241-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.