Strain Name:
C57BL/6J-MtgxR6108Btlr
Stock Number:
044258-MU
Citation ID:
RRID:MMRRC_044258-MU
Other Names:
R6108 (G1)
Major Collection:

Gene Information

Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Nae1
Name: NEDD8 activating enzyme E1 subunit 1
Synonyms: Appbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234664
HGNC: HGNC:621
Homologene: 68370
Ptprf
Name: protein tyrosine phosphatase, receptor type, F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24127
Homologene: 5894
Axin1
Name: axin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12005
HGNC: HGNC:903
Homologene: 2614
Hspa4
Name: heat shock protein 4
Synonyms: APG-2, Hsp70RY, Hsp110, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Caprin1
Name: cell cycle associated protein 1
Synonyms: MMGPIP137, caprin-1, Gpiap1, RNG105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53872
HGNC: HGNC:6743
Homologene: 4310
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Igf2bp3
Name: insulin-like growth factor 2 mRNA binding protein 3
Synonyms: 2610101N11Rik, IMP3, Koc13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 140488
Homologene: 4773
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, EFG2, A930009M04Rik, 6530419G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 320806
Homologene: 6238
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Plpp1
Name: phospholipid phosphatase 1
Synonyms: mPAP, Lipid phosphate phosphatase 1, LPP1, LPP-1, Hpic53, Ppap2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19012
VEGA: 13
HGNC: HGNC:9228
Homologene: 134049
Aptx
Name: aprataxin
Synonyms: 2410016G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66408
Homologene: 41634
Mei1
Name: meiotic double-stranded break formation protein 1
Synonyms: mei1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74369
Homologene: 46535
Gna14
Name: guanine nucleotide binding protein, alpha 14
Synonyms: G alpha 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14675
VEGA: 19
HGNC: HGNC:4382
Homologene: 68386
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Tspan12
Name: tetraspanin 12
Synonyms: Tm4sf12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269831
Homologene: 8212
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 546144
Homologene: 52326
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Fermt3
Name: fermitin family member 3
Synonyms: C79673, Kindlin-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 108101
VEGA: 19
Homologene: 12877
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Plek
Name: pleckstrin
Synonyms: 2010300B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56193
HGNC: HGNC:9070
Homologene: 2000
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: VR16, V2r16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22307
Homologene: 129606
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20274
Homologene: 2237
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: LOC381522, E230008N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381522
Homologene: 117988
Nsun7
Name: NOL1/NOP2/Sun domain family, member 7
Synonyms: 4921525L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70918
Homologene: 11653
Chrm2
Name: cholinergic receptor, muscarinic 2, cardiac
Synonyms: M2, AChR M2, muscarinic acetylcholine receptor 2, Chrm-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243764
HGNC: HGNC:1951
Homologene: 20190
Nudt12
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 12
Synonyms: 0610016O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67993
Homologene: 44188
Dsg1a
Name: desmoglein 1 alpha
Synonyms: Dsg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13510
HGNC: HGNC:3048
Homologene: 1463
Kcnb1
Name: potassium voltage gated channel, Shab-related subfamily, member 1
Synonyms: Kv2.1, Kcr1-1, Shab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16500
HGNC: HGNC:6231
Homologene: 37988
Mmrn1
Name: multimerin 1
Synonyms: 4921530G03Rik, Emilin4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Cyp2d22
Name: cytochrome P450, family 2, subfamily d, polypeptide 22
Synonyms: 2D22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56448
VEGA: 15
Homologene: 75003
Btbd2
Name: BTB (POZ) domain containing 2
Synonyms: 2610037C03Rik, 4930512K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 208198
Homologene: 32365
P2ry1
Name: purinergic receptor P2Y, G-protein coupled 1
Synonyms: P2Y1, P2Y1 receptor, P2y1r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18441
HGNC: HGNC:8539
Homologene: 1926
Smtn
Name: smoothelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 29856
Homologene: 8482
Il1rap
Name: interleukin 1 receptor accessory protein
Synonyms: IL-1R AcP, IL-1RAcP, 6430709H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16180
HGNC: HGNC:5995
Homologene: 1643
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269437
Homologene: 88833
Tas2r144
Name: taste receptor, type 2, member 144
Synonyms: mt2r33, Tas2r44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387515
Homologene: 47977
Vmn1r71
Name: vomeronasal 1 receptor 71
Synonyms: V1re13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252910
Homologene: 74352
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224576
Homologene: 135824
Ccdc136
Name: coiled-coil domain containing 136
Synonyms: 4921511K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232664
Homologene: 23378
Lmod1
Name: leiomodin 1 (smooth muscle)
Synonyms: 64kD D1, 1D, D1, SM-Lmod, 9530015K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 93689
HGNC: HGNC:6647
Homologene: 8118
Tjp3
Name: tight junction protein 3
Synonyms: ZO-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27375
VEGA: 10
Homologene: 8458
Fam167b
Name: family with sequence similarity 167, member B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230766
Homologene: 13085
Slc6a20b
Name: solute carrier family 6 (neurotransmitter transporter), member 20B
Synonyms: XT3, Xtrp3, Sit1, Slc6a20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22599
Homologene: 130652
Tnip3
Name: TNFAIP3 interacting protein 3
Synonyms: 9030611K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 414084
Homologene: 47979
Olfr365
Name: olfactory receptor 365
Synonyms: GA_x6K02T2NLDC-33885305-33886243, MOR138-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258656
Homologene: 74156
Slfnl1
Name: schlafen like 1
Synonyms: 4933406A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194219
Homologene: 44913
Kcnn1
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
Synonyms: SK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 84036
HGNC: HGNC:6290
Homologene: 37595
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: Maspin, Spi7, ovalbumin, 1110036M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
Ptges3-ps
Name: prostaglandin E synthase 3, pseudogene
Synonyms: Gm9769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100043508
Homologene: 128197
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 53,456,845 bp
  • T to A, chromosome 1 at 106,881,728 bp
  • G to A, chromosome 1 at 135,364,111 bp
  • A to G, chromosome 1 at 150,631,227 bp
  • A to T, chromosome 1 at 189,662,013 bp
  • T to C, chromosome 2 at 37,201,766 bp
  • T to C, chromosome 2 at 66,484,049 bp
  • T to A, chromosome 2 at 76,878,041 bp
  • C to T, chromosome 2 at 103,776,017 bp
  • G to A, chromosome 2 at 167,105,140 bp
  • T to A, chromosome 3 at 61,004,175 bp
  • C to T, chromosome 3 at 63,702,023 bp
  • G to A, chromosome 4 at 40,694,986 bp
  • A to G, chromosome 4 at 45,911,389 bp
  • A to G, chromosome 4 at 118,223,256 bp
  • A to G, chromosome 4 at 120,533,361 bp
  • A to T, chromosome 4 at 129,578,308 bp
  • T to A, chromosome 5 at 66,295,799 bp
  • A to G, chromosome 5 at 108,995,801 bp
  • T to A, chromosome 6 at 21,772,771 bp
  • A to T, chromosome 6 at 23,045,659 bp
  • C to A, chromosome 6 at 29,412,450 bp
  • T to A, chromosome 6 at 36,523,295 bp
  • C to A, chromosome 6 at 42,215,757 bp
  • A to G, chromosome 6 at 49,117,374 bp
  • G to A, chromosome 6 at 60,975,976 bp
  • A to G, chromosome 6 at 65,525,411 bp
  • C to T, chromosome 6 at 85,844,555 bp
  • T to C, chromosome 7 at 10,748,618 bp
  • A to C, chromosome 8 at 70,855,156 bp
  • A to G, chromosome 8 at 95,730,420 bp
  • A to T, chromosome 8 at 104,527,402 bp
  • A to G, chromosome 9 at 74,151,668 bp
  • A to T, chromosome 9 at 95,974,427 bp
  • T to G, chromosome 9 at 123,596,186 bp
  • A to T, chromosome 10 at 80,645,531 bp
  • C to T, chromosome 10 at 81,281,146 bp
  • C to A, chromosome 10 at 123,032,695 bp
  • C to A, chromosome 11 at 3,529,608 bp
  • T to A, chromosome 11 at 16,990,058 bp
  • C to T, chromosome 11 at 53,261,712 bp
  • A to G, chromosome 13 at 81,391,695 bp
  • A to G, chromosome 13 at 97,149,422 bp
  • A to T, chromosome 13 at 112,866,865 bp
  • A to T, chromosome 15 at 82,075,188 bp
  • T to C, chromosome 15 at 82,371,905 bp
  • G to A, chromosome 16 at 26,722,707 bp
  • G to A, chromosome 17 at 20,268,376 bp
  • T to A, chromosome 17 at 26,143,240 bp
  • C to A, chromosome 17 at 59,007,749 bp
  • T to A, chromosome 18 at 20,340,247 bp
  • G to A, chromosome 19 at 4,731,392 bp
  • C to A, chromosome 19 at 7,014,414 bp
  • A to G, chromosome 19 at 16,603,343 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6108 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044258-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.