Strain Name:
C57BL/6J-MtgxR6114Btlr
Stock Number:
044263-MU
Citation ID:
RRID:MMRRC_044263-MU
Other Names:
R6114 (G1)
Major Collection:

Gene Information

Pitx2
Name: paired-like homeodomain transcription factor 2
Synonyms: Brx1b, Rieg, Brx1a, Pitx2a, Pitx2b, Pitx2c, Munc30, Brx1, solurshin, Otlx2, Ptx2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18741
HGNC: HGNC:9005
Homologene: 55454
Ank2
Name: ankyrin 2, brain
Synonyms: Ank-2, ankyrin B, Gm4392, Ankyrin-B, Ankyrin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Cd14
Name: CD14 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12475
VEGA: 18
HGNC: HGNC:1628
Homologene: 493
Blm
Name: Bloom syndrome, RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12144
HGNC: HGNC:1058
Homologene: 47902
Mfn1
Name: mitofusin 1
Synonyms: HR2, 2310002F04Rik, D3Ertd265e, 6330416C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67414
Homologene: 11481
Arid5b
Name: AT rich interactive domain 5B (MRF1-like)
Synonyms: 5430435G07Rik, Mrf2, Mrf2alpha, Mrf2beta, Desrt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: Nav1.6, mnd2, mnd-2, motor end-plate disease, nur14, ataxia 3, seal, nmf58, NaCh6, nmf335, NMF335, C630029C19Rik, nmf2, med
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20273
Homologene: 7927
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Af4, Mllt2h, 9630032B01Rik, Rob
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, Cain, A330070M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Copb1
Name: coatomer protein complex, subunit beta 1
Synonyms: Copb1, 2610019B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70349
HGNC: HGNC:2231
Homologene: 5664
Samd4b
Name: sterile alpha motif domain containing 4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233033
Homologene: 35268
Slc45a4
Name: solute carrier family 45, member 4
Synonyms: 9330175B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 106068
Homologene: 69908
Slc38a10
Name: solute carrier family 38, member 10
Synonyms: 1810073N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72055
Homologene: 41556
Stx7
Name: syntaxin 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 53331
VEGA: 10
Homologene: 37823
Zbtb40
Name: zinc finger and BTB domain containing 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230848
Homologene: 8912
Smyd5
Name: SET and MYND domain containing 5
Synonyms: Rai15, Rrg1, NN8-4AG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232187
Homologene: 6143
Hsph1
Name: heat shock 105kDa/110kDa protein 1
Synonyms: Hsp105, HSP110, hsp110/105, hsp-E7I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15505
Homologene: 21322
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Sox8
Name: SRY (sex determining region Y)-box 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20681
Homologene: 7950
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: 9330188B09Rik, D630001M17Rik, 4921513O20Rik, cI-46, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Egfr
Name: epidermal growth factor receptor
Synonyms: Wa5, 9030024J15Rik, Errb1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Cpxm2
Name: carboxypeptidase X 2 (M14 family)
Synonyms: 4632435C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 55987
Homologene: 69259
Reck
Name: reversion-inducing-cysteine-rich protein with kazal motifs
Synonyms: St15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 53614
Homologene: 9622
Tcf25
Name: transcription factor 25 (basic helix-loop-helix)
Synonyms: 1100001J13Rik, 1810041K11Rik, D8Ertd325e, Nulp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66855
Homologene: 5701
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225115
Homologene: 25090
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: D930026N18Rik, Cchl1a1, Cav1.2, (alpha)1 subunit, L-type Cav1.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Lmod2
Name: leiomodin 2 (cardiac)
Synonyms: C-Lmod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93677
HGNC: HGNC:6648
Homologene: 28302
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627636
Homologene: 115024
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268933
Homologene: 6870
Cntnap4
Name: contactin associated protein-like 4
Synonyms: E130114F09Rik, Caspr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170571
Homologene: 24912
Olfr771
Name: olfactory receptor 771
Synonyms: MOR114-8, GA_x6K02T2PULF-10846420-10845467
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258540
Homologene: 74047
Gm884
Name: predicted gene 884
Synonyms: LOC380730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380730
Homologene: 134511
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 4930518F03Rik, 3830402K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320558
Homologene: 8604
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382090
Homologene: 8930
Rora
Name: RAR-related orphan receptor alpha
Synonyms: Nr1f1, 9530021D13Rik, tmgc26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19883
Homologene: 56594
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cavbeta2, Cchb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Usp13
Name: ubiquitin specific peptidase 13 (isopeptidase T-3)
Synonyms: ISOT3, IsoT-3, 2700071E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72607
Homologene: 68372
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70381
Homologene: 9120
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Vmn1r173
Name: vomeronasal 1 receptor 173
Synonyms: Gm5892
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545934
Homologene: 79577
Zfp651
Name: zinc finger protein 651
Synonyms: 4732420M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270210
VEGA: 9
Homologene: 136302
Adamdec1
Name: ADAM-like, decysin 1
Synonyms: 2210414L24Rik, Dcsn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 58860
VEGA: 14
Homologene: 8711
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243937
Homologene: 8813
Nrd1
Name: nardilysin, N-arginine dibasic convertase, NRD convertase 1
Synonyms: NRD-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230598
HGNC: HGNC:7995
Homologene: 68260
Teddm1a
Name: transmembrane epididymal protein 1A
Synonyms: Epdd1, e9-1, Teddm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240819
Homologene: 82370
Slc22a15
Name: solute carrier family 22 (organic anion/cation transporter), member 15
Synonyms: 2610034P21Rik, A530052I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242126
Homologene: 41263
Slc24a5
Name: solute carrier family 24, member 5
Synonyms: F630045L20Rik, NCX5, NCKX5, Oca6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 317750
Homologene: 18400
Endou
Name: endonuclease, polyU-specific
Synonyms: Pp11r, Tcl-30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19011
VEGA: 15
Homologene: 48394
Usp17lb
Name: ubiquitin specific peptidase 17-like B
Synonyms: Dub1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381944
Homologene: 131315
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224576
Homologene: 135824
Olfr355
Name: olfactory receptor 355
Synonyms: MOR138-2, GA_x6K02T2NLDC-33622642-33621710
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258618
Homologene: 132326
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240084
Homologene: 10396
Olfr516
Name: olfactory receptor 516
Synonyms: GA_x6K02T2PBJ9-11176324-11175380, MOR268-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258720
HGNC: HGNC:8162
Homologene: 138316
Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: Rxrip14, HRR1, RIP14, FXR, Fxr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20186
HGNC: HGNC:7967
Homologene: 3760
Lpar5
Name: lysophosphatidic acid receptor 5
Synonyms: Gpr92, GPR93, LOC381810, LPA5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381810
Homologene: 10696
Hoxd9
Name: homeobox D9
Synonyms: Hox-5.2, Hox-4.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15438
HGNC: HGNC:5140
Homologene: 8409
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207728
HGNC: HGNC:8777
Homologene: 1952
Ahcy
Name: S-adenosylhomocysteine hydrolase
Synonyms: CuBP, SAHH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269378
HGNC: HGNC:343
Homologene: 554
Art4
Name: ADP-ribosyltransferase 4
Synonyms: DO, 4432404K01Rik, DOK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109978
HGNC: HGNC:726
Homologene: 10883
Ms4a12
Name: membrane-spanning 4-domains, subfamily A, member 12
Synonyms: LOC381213
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381213
Homologene: 130690
Igkv4-78
Name: immunoglobulin kappa variable 4-78
Synonyms: Igkv4-78 immunoglobulin light chain variable region
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545849
Pcdhgc3
Name: protocadherin gamma subfamily C, 3
Synonyms: PC43, Pcdh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93706
HGNC: HGNC:8716
Homologene: 31099
Lst1
Name: leukocyte specific transcript 1
Synonyms: B144
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16988
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 153,891,868 bp
  • A to T, chromosome 2 at 14,975,201 bp
  • A to T, chromosome 2 at 36,927,689 bp
  • A to G, chromosome 2 at 74,699,365 bp
  • A to G, chromosome 2 at 125,083,092 bp
  • A to C, chromosome 2 at 155,062,159 bp
  • G to C, chromosome 2 at 178,348,245 bp
  • C to A, chromosome 3 at 32,563,836 bp
  • C to T, chromosome 3 at 32,854,669 bp
  • G to T, chromosome 3 at 96,649,035 bp
  • A to T, chromosome 3 at 101,860,852 bp
  • T to C, chromosome 3 at 127,011,051 bp
  • C to G, chromosome 3 at 129,204,413 bp
  • T to A, chromosome 4 at 43,922,895 bp
  • A to T, chromosome 4 at 109,044,585 bp
  • T to A, chromosome 4 at 136,988,691 bp
  • T to C, chromosome 5 at 103,842,297 bp
  • C to T, chromosome 5 at 144,204,640 bp
  • C to A, chromosome 5 at 149,627,387 bp
  • A to G, chromosome 6 at 24,603,692 bp
  • T to A, chromosome 6 at 69,059,759 bp
  • A to T, chromosome 6 at 85,440,262 bp
  • T to C, chromosome 6 at 118,596,140 bp
  • A to G, chromosome 6 at 125,081,676 bp
  • T to A, chromosome 6 at 136,857,213 bp
  • A to G, chromosome 7 at 23,702,829 bp
  • A to G, chromosome 7 at 28,522,792 bp
  • A to T, chromosome 7 at 37,479,736 bp
  • T to C, chromosome 7 at 80,513,487 bp
  • A to T, chromosome 7 at 101,511,112 bp
  • T to A, chromosome 7 at 104,840,364 bp
  • A to T, chromosome 7 at 108,845,386 bp
  • T to A, chromosome 7 at 114,246,801 bp
  • A to G, chromosome 7 at 132,154,306 bp
  • A to G, chromosome 8 at 112,841,753 bp
  • A to T, chromosome 8 at 123,384,375 bp
  • T to C, chromosome 8 at 125,773,947 bp
  • A to G, chromosome 9 at 69,371,323 bp
  • A to G, chromosome 9 at 87,203,710 bp
  • T to A, chromosome 9 at 121,765,595 bp
  • A to G, chromosome 10 at 24,184,985 bp
  • T to C, chromosome 10 at 68,097,744 bp
  • T to A, chromosome 10 at 75,747,971 bp
  • T to A, chromosome 10 at 89,478,816 bp
  • T to A, chromosome 10 at 129,160,333 bp
  • A to G, chromosome 11 at 16,904,374 bp
  • T to A, chromosome 11 at 103,617,791 bp
  • G to A, chromosome 11 at 120,129,312 bp
  • G to A, chromosome 13 at 3,590,081 bp
  • C to A, chromosome 14 at 68,571,803 bp
  • G to A, chromosome 15 at 73,605,604 bp
  • A to G, chromosome 15 at 91,747,826 bp
  • T to A, chromosome 15 at 97,713,876 bp
  • A to G, chromosome 15 at 101,040,596 bp
  • G to T, chromosome 17 at 19,812,325 bp
  • G to A, chromosome 17 at 20,268,376 bp
  • T to C, chromosome 17 at 25,567,520 bp
  • C to T, chromosome 17 at 25,824,605 bp
  • T to C, chromosome 17 at 35,188,360 bp
  • A to G, chromosome 17 at 35,525,330 bp
  • T to C, chromosome 18 at 5,108,639 bp
  • A to G, chromosome 18 at 36,725,953 bp
  • C to G, chromosome 18 at 37,807,872 bp
  • G to T, chromosome 19 at 11,215,290 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6114 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044263-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.