Strain Name:
C57BL/6J-MtgxR6116Btlr
Stock Number:
044265-MU
Citation ID:
RRID:MMRRC_044265-MU
Other Names:
R6116 (G1)
Major Collection:

Gene Information

Olr1
Name: oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms: LOX-1, Scare1, SR-EI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108078
HGNC: HGNC:8133
Homologene: 1910
Tcf7l2
Name: transcription factor 7 like 2, T cell specific, HMG box
Synonyms: mTcf-4E, Tcf4, TCF4E, TCF4B, Tcf-4, mTcf-4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21416
Homologene: 7564
Lpin2
Name: lipin 2
Synonyms: 2610511G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 64898
Homologene: 8769
Neurod6
Name: neurogenic differentiation 6
Synonyms: Nex, Nex1m, Math-2, bHLHa2, Atoh2, Math2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11922
Homologene: 7632
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: CC1, adenomatosis polyposis coli, Min
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Itsn2
Name: intersectin 2
Synonyms: Sh3d1B, Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3p18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Exosc10
Name: exosome component 10
Synonyms: Pmscl2, PM-Scl, RRP6, p4, p3, p2, PM/Scl-100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Peg10
Name: paternally expressed 10
Synonyms: Mar2, MyEF-3, Rtl2, HB-1, MEF3L, Mart2, MyEF-3 like, Edr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170676
Homologene: 116067
Slc7a2
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms: Atrc2, Cat2, Tea
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11988
Homologene: 20659
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237979
Homologene: 10406
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268933
Homologene: 6870
Stab2
Name: stabilin 2
Synonyms: FEEL-2, STAB-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
Bpifa3
Name: BPI fold containing family A, member 3
Synonyms: 1700058C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73388
Homologene: 52268
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: Moca, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 1110004P15Rik, DY6, 2310047C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Ttc41
Name: tetratricopeptide repeat domain 41
Synonyms: BC030307, Gnn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103220
VEGA: 10
Homologene: 52968
Glmn
Name: glomulin, FKBP associated protein
Synonyms: Fap48, 9330160J16Rik, Fap68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 170823
Homologene: 14239
Jade2
Name: jade family PHD finger 2
Synonyms: 1200017K05Rik, Phf15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76901
Homologene: 9082
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226438
Homologene: 130054
Ppfia3
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Synonyms: 2410127E16Rik, Liprin-alpha3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76787
HGNC: HGNC:9247
Homologene: 37833
Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Synonyms: HER2, c-neu, l11Jus8, c-erbB2, ErbB-2, Neu, HER-2, Neu oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13866
HGNC: HGNC:3430
Homologene: 3273
Eno3
Name: enolase 3, beta muscle
Synonyms: Eno-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13808
HGNC: HGNC:3354
Homologene: 68215
Gm15446
Name: predicted gene 15446
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100642166
Gm597
Name: predicted gene 597
Synonyms: LOC210962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210962
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269437
Homologene: 88833
Olfr96
Name: olfactory receptor 96
Synonyms: MOR121-1, GA_x6K02T2PSCP-1665046-1665987
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258507
HGNC: HGNC:8176
Homologene: 27189
Myb
Name: myeloblastosis oncogene
Synonyms: c-myb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17863
HGNC: HGNC:7545
Homologene: 31311
Olfr878
Name: olfactory receptor 878
Synonyms: MOR163-1, GA_x6K02T2PVTD-31600511-31601440
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258794
HGNC: HGNC:8473
Homologene: 17395
Dsc1
Name: desmocollin 1
Synonyms: Dsc1b, Dsc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13505
VEGA: 18
HGNC: HGNC:3035
Homologene: 22761
Cyp2c67
Name: cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms: C730004C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 545288
Homologene: 74936
Slc16a11
Name: solute carrier family 16 (monocarboxylic acid transporters), member 11
Synonyms: MNCb-2717
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216867
Homologene: 27409
Lpar3
Name: lysophosphatidic acid receptor 3
Synonyms: LPA3, Edg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 65086
Homologene: 8123
Hspa8
Name: heat shock protein 8
Synonyms: 2410008N15Rik, Hsc73, Hsc71, Hsc70, Hsp73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15481
HGNC: HGNC:5241
Homologene: 68524
Vmn2r32
Name: vomeronasal 2, receptor 32
Synonyms: V2r5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22311
Homologene: 113703
Ms4a8a
Name: membrane-spanning 4-domains, subfamily A, member 8A
Synonyms: Ms4a8, 2010004L09Rik, CD20L5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 64381
Homologene: 111037
Mosmo
Name: modulator of smoothened
Synonyms: BC030336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233812
Homologene: 16600
Slc2a10
Name: solute carrier family 2 (facilitated glucose transporter), member 10
Synonyms: Glut10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 170441
Homologene: 38551
Igkv12-44
Name: immunoglobulin kappa variable 12-44
Synonyms: Gm16851
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545851
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 28,778,699 bp
  • T to C, chromosome 1 at 135,970,467 bp
  • G to A, chromosome 2 at 154,133,713 bp
  • A to C, chromosome 2 at 165,517,703 bp
  • C to T, chromosome 3 at 63,702,023 bp
  • T to A, chromosome 3 at 146,240,597 bp
  • T to C, chromosome 4 at 148,573,353 bp
  • A to T, chromosome 5 at 107,557,340 bp
  • T to A, chromosome 5 at 109,943,036 bp
  • C to CCCATCAGGA, chromosome 6 at 4,756,351 bp
  • T to C, chromosome 6 at 55,678,791 bp
  • T to C, chromosome 6 at 69,814,854 bp
  • T to A, chromosome 6 at 129,499,984 bp
  • A to T, chromosome 7 at 7,464,093 bp
  • T to C, chromosome 7 at 45,354,703 bp
  • T to A, chromosome 7 at 120,726,195 bp
  • T to A, chromosome 8 at 16,211,850 bp
  • T to C, chromosome 8 at 40,900,169 bp
  • A to G, chromosome 9 at 37,918,659 bp
  • A to G, chromosome 9 at 40,804,975 bp
  • A to G, chromosome 9 at 106,931,962 bp
  • T to C, chromosome 10 at 21,154,754 bp
  • G to A, chromosome 10 at 86,759,088 bp
  • G to T, chromosome 10 at 86,907,190 bp
  • T to C, chromosome 11 at 51,835,633 bp
  • T to C, chromosome 11 at 70,215,436 bp
  • C to T, chromosome 11 at 70,661,575 bp
  • T to A, chromosome 11 at 98,427,399 bp
  • T to A, chromosome 11 at 113,854,364 bp
  • T to C, chromosome 12 at 4,629,939 bp
  • C to T, chromosome 17 at 25,824,605 bp
  • A to G, chromosome 17 at 37,225,568 bp
  • A to G, chromosome 17 at 71,243,930 bp
  • G to T, chromosome 18 at 20,097,299 bp
  • A to T, chromosome 18 at 34,316,455 bp
  • T to A, chromosome 19 at 9,012,963 bp
  • C to T, chromosome 19 at 11,081,072 bp
  • A to T, chromosome 19 at 39,617,435 bp
  • T to A, chromosome 19 at 55,919,014 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6116 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044265-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.