Strain Name:
C57BL/6J-MtgxR6127Btlr/Mmmh
Stock Number:
044274-MU
Citation ID:
RRID:MMRRC_044274-MU
Other Names:
R6127 (G1)
Major Collection:

Gene Information

Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24127
Homologene: 5894
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Ddx50
Name: DExD box helicase 50
Synonyms: GU2, RH-II/Gubeta, 4933429B04Rik, 8430408E17Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 94213
VEGA: 10
Homologene: 56986
Ireb2
Name: iron responsive element binding protein 2
Synonyms: Irp2, D9Ertd85e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64602
VEGA: 9
HGNC: HGNC:6115
Homologene: 11280
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
Fblim1
Name: filamin binding LIM protein 1
Synonyms: 2410043F08Rik, migfilin(s), migfilin, Fblp1, Cal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74202
Homologene: 56774
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Trip4
Name: thyroid hormone receptor interactor 4
Synonyms: ASC-1, 4930558E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56404
Homologene: 9426
Stag1
Name: stromal antigen 1
Synonyms: SA-1, Scc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20842
Homologene: 21191
Pold1
Name: polymerase (DNA directed), delta 1, catalytic subunit
Synonyms: 125kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18971
HGNC: HGNC:9175
Homologene: 2014
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19876
Homologene: 2206
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 73732
Homologene: 141193
Maea
Name: macrophage erythroblast attacher
Synonyms: 1110030D19Rik, Gid9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 59003
Homologene: 4298
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: SRrp53, 1200013F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66880
Homologene: 41147
Atp2b2
Name: ATPase, Ca++ transporting, plasma membrane 2
Synonyms: PMCA2, D6Abb2e, wms, jog, Tmy, Gena300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11941
HGNC: HGNC:815
Homologene: 56150
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Epha5
Name: Eph receptor A5
Synonyms: Cek7, bsk, Els1, Rek7, Hek7, Ehk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9430004C13Rik, 9630046L06Rik, 1110061O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Pak5
Name: p21 (RAC1) activated kinase 5
Synonyms: Pak5, 2900083L08Rik, Pak7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241656
Homologene: 22211
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Akna
Name: AT-hook transcription factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100182
Homologene: 49947
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: merg1a, ether a go-go related, M-erg, LQT, Lqt2, ERG1, merg1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
4931429L15Rik
Name: RIKEN cDNA 4931429L15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74361
Homologene: 86847
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Tyro 12, Nyk, Eyk, Mer, nmf12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Olfr291
Name: olfactory receptor 291
Synonyms: GA_x6K02T2NHDJ-11231385-11230438, MOR254-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258410
Homologene: 83130
Hexdc
Name: hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238023
Homologene: 68120
Cactin
Name: cactin, spliceosome C complex subunit
Synonyms: 2510012J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70312
VEGA: 10
Homologene: 69553
Olfr1156
Name: olfactory receptor 1156
Synonyms: GA_x6K02T2Q125-49433499-49432537, MOR174-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258814
HGNC: HGNC:8351
Homologene: 72031
Prag1
Name: PEAK1 related kinase activating pseudokinase 1
Synonyms: NACK, D8Ertd82e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244418
Homologene: 18256
Setd7
Name: SET domain containing (lysine methyltransferase) 7
Synonyms: 1600028F23Rik, Set7, KMT7, Set7/9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 73251
Homologene: 12741
Olfr816
Name: olfactory receptor 816
Synonyms: GA_x6K02T2PULF-11590830-11589892, MOR113-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258667
Homologene: 133584
Olfr1389
Name: olfactory receptor 1389
Synonyms: GA_x6K02T2QP88-6004387-6003452, MOR256-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259069
Homologene: 86690
Zfp647
Name: zinc finger protein 647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239546
VEGA: 15
Homologene: 27805
Wee2
Name: WEE1 homolog 2 (S. pombe)
Synonyms: LOC381759, Wee1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381759
Homologene: 52392
Vmn1r200
Name: vomeronasal 1 receptor 200
Synonyms: V1rh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171246
Homologene: 110880
Actl9
Name: actin-like 9
Synonyms: 1700029I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69481
Homologene: 77642
Hagh
Name: hydroxyacyl glutathione hydrolase
Synonyms: Rsp29, Glo-2, Glo2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14651
HGNC: HGNC:4805
Homologene: 3890
Vmn2r51
Name: vomeronasal 2, receptor 51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042921
Homologene: 113703
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: Afuc, 0610006A03Rik, 9530055J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Muc13
Name: mucin 13, epithelial transmembrane
Synonyms: 114/A10, Ly64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17063
HGNC: HGNC:7511
Homologene: 7822
Bend7
Name: BEN domain containing 7
Synonyms: 1110017O21Rik, E130319B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209645
Homologene: 17660
Tulp1
Name: tubby like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22157
Homologene: 2491
1700003F12Rik
Name: RIKEN cDNA 1700003F12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75480
Homologene: 136196
Slc25a41
Name: solute carrier family 25, member 41
Synonyms: 4933406J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 103775
Homologene: 27855
Psg29
Name: pregnancy-specific glycoprotein 29
Synonyms: cea17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114872
Homologene: 83380
Leng1
Name: leukocyte receptor cluster (LRC) member 1
Synonyms: 1500001K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69757
Homologene: 11520
Svip
Name: small VCP/p97-interacting protein
Synonyms: 1700006C13Rik, 6620401M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75744
Homologene: 85776
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Pcdhga3
Name: protocadherin gamma subfamily A, 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93711
HGNC: HGNC:8701
Homologene: 75100
Trav19
Name: T cell receptor alpha variable 19
Synonyms: Gm13893
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 547428
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 4,349,311 bp
  • T to C, chromosome 1 at 88,234,612 bp
  • A to G, chromosome 2 at 4,763,277 bp
  • T to A, chromosome 2 at 87,949,361 bp
  • G to T, chromosome 2 at 128,738,291 bp
  • G to A, chromosome 2 at 136,087,406 bp
  • A to G, chromosome 2 at 154,549,589 bp
  • G to A, chromosome 3 at 51,530,081 bp
  • C to T, chromosome 3 at 66,994,649 bp
  • T to A, chromosome 3 at 116,758,329 bp
  • G to T, chromosome 4 at 63,368,119 bp
  • T to A, chromosome 4 at 135,934,811 bp
  • G to A, chromosome 4 at 141,584,722 bp
  • A to G, chromosome 5 at 24,325,003 bp
  • C to T, chromosome 5 at 33,335,518 bp
  • T to G, chromosome 5 at 84,071,094 bp
  • T to C, chromosome 6 at 40,449,767 bp
  • C to T, chromosome 6 at 113,813,877 bp
  • G to A, chromosome 7 at 3,662,867 bp
  • A to T, chromosome 7 at 10,105,631 bp
  • T to A, chromosome 7 at 17,211,746 bp
  • T to C, chromosome 7 at 44,542,121 bp
  • T to C, chromosome 7 at 52,003,453 bp
  • T to A, chromosome 7 at 84,857,202 bp
  • A to T, chromosome 7 at 130,626,115 bp
  • T to C, chromosome 8 at 36,147,401 bp
  • T to A, chromosome 9 at 18,657,878 bp
  • T to A, chromosome 9 at 46,308,922 bp
  • A to C, chromosome 9 at 53,524,509 bp
  • A to G, chromosome 9 at 54,882,368 bp
  • A to T, chromosome 9 at 65,866,470 bp
  • T to C, chromosome 9 at 95,969,489 bp
  • T to C, chromosome 9 at 100,951,697 bp
  • A to T, chromosome 10 at 62,621,563 bp
  • G to A, chromosome 10 at 81,324,309 bp
  • A to G, chromosome 10 at 129,911,415 bp
  • C to A, chromosome 11 at 49,430,806 bp
  • T to C, chromosome 11 at 121,216,999 bp
  • A to T, chromosome 13 at 22,395,203 bp
  • T to C, chromosome 13 at 24,036,352 bp
  • A to G, chromosome 14 at 53,845,542 bp
  • A to G, chromosome 14 at 84,533,060 bp
  • T to A, chromosome 15 at 47,650,228 bp
  • G to A, chromosome 15 at 76,912,085 bp
  • G to A, chromosome 16 at 33,798,947 bp
  • A to T, chromosome 16 at 73,013,068 bp
  • G to T, chromosome 17 at 24,861,004 bp
  • T to A, chromosome 17 at 28,356,150 bp
  • T to C, chromosome 17 at 33,433,380 bp
  • T to A, chromosome 17 at 57,034,914 bp
  • A to T, chromosome 18 at 37,674,704 bp
  • C to A, chromosome 18 at 37,732,879 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6127 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044274-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.